With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.253429-31-1,7-Bromo-4-fluorobenzofuran,as a common compound, the synthetic route is as follows.,253429-31-1
Step C- Synthesis of Compound 16D; A solution of compound 16C (124.12 g, 577.25 mmol) in ether (2.0 L) was cooled to – 78 0C and treated dropwise with a solution of 2.5 M of n-butyllithium in hexane (235.5 mL) and allowed to stir at -78 C for 15 minutes. To this reaction mixture was added DMF (89.393 mL, 1.15 mol) and allowed to stir at -78 C for 30 minutes. The reaction mixture was quenched with methanol (23.383 mL, 577.25 mmol) and warmed to room temperature. The reaction mixture was diluted with ether (300 mL) and the organic layer was washed with water (300 mL). The separated organic layer was dried (MgSO4) filtered, concentrated in vacuo to provide compound 16D (89.00 g, 93.9%).
The synthetic route of 253429-31-1 has been constantly updated, and we look forward to future research findings.