With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.
652-39-1, A mixture of 3 -fluorophthalic anhydride (1 equiv.), 1 -amino-3 -(4-methoxybenzyl)-3 – azabicyclo[3.1.0]hexane-2,4-dione (1 equiv.), and potassium acetate (2.5 equiv.) in acetic acid is stirred at 120 ¡ãC overnight. The dark mixture is cooled and filtered. The filter cake is dissolved inDCM and washed with saturated NaHCO3 and brine. The organic layer is dried (Na2504) and concentrated to provide 4-fluoro adduct.To a solution of the resulting residue (1.0 equiv) in CH3CN, cooled to 0 ¡ãC, is added a solution of CAN (3.0 equiv) in H20, and the yellow clear solution is stirred at 0 ¡ãC for 2 h. Then it is diluted with EtOAc and quenched with half saturated aqueous NaC1 and diluted with EtOAcand H20. The phases are separated, and the aqueous phase is extracted with EtOAc (2 x) and CH2C12 (2 x). The combined organic phases are dried (Na2504), filtered, and concentrated in vacuo. The residue is purified by column chromatography on silica gel to provide 2-(2,4-dioxo-3- azabicyclo[3. 1. 0]hexan- 1 -yl)-4-fluoroisoindoline- 1,3 -dione. (Org. Lett. 2013, 15, 4312)
As the paragraph descriping shows that 652-39-1 is playing an increasingly important role.
Reference£º
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; FITZGERALD, Mark, E.; MICHAEL, Ryan, E.; (790 pag.)WO2017/197056; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem