Tag: 652-39-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

652-39-1, A mixture of 3 -fluorophthalic anhydride (1 equiv.), 1 -amino-3 -(4-methoxybenzyl)-3 – azabicyclo[3.1.0]hexane-2,4-dione (1 equiv.), and potassium acetate (2.5 equiv.) in acetic acid is stirred at 120 ¡ãC overnight. The dark mixture is cooled and filtered. The filter cake is dissolved inDCM and washed with saturated NaHCO3 and brine. The organic layer is dried (Na2504) and concentrated to provide 4-fluoro adduct.To a solution of the resulting residue (1.0 equiv) in CH3CN, cooled to 0 ¡ãC, is added a solution of CAN (3.0 equiv) in H20, and the yellow clear solution is stirred at 0 ¡ãC for 2 h. Then it is diluted with EtOAc and quenched with half saturated aqueous NaC1 and diluted with EtOAcand H20. The phases are separated, and the aqueous phase is extracted with EtOAc (2 x) and CH2C12 (2 x). The combined organic phases are dried (Na2504), filtered, and concentrated in vacuo. The residue is purified by column chromatography on silica gel to provide 2-(2,4-dioxo-3- azabicyclo[3. 1. 0]hexan- 1 -yl)-4-fluoroisoindoline- 1,3 -dione. (Org. Lett. 2013, 15, 4312)

As the paragraph descriping shows that 652-39-1 is playing an increasingly important role.

Reference£º
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; FITZGERALD, Mark, E.; MICHAEL, Ryan, E.; (790 pag.)WO2017/197056; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

652-39-1, Combine the two ammonium salt mixtures from Example 1 (8.86 g, 1 eq), NaBH4 (8.37 g, 5 eq), and tetrahydrofuran (123 ml) into the reaction flask and allow the mixture to cool.A solution of BF3 in tetrahydrofuran (30.77 g, 5 eq) was added dropwise and incubated.After the addition was complete, the mixture was stirred and refluxed overnight. Methanol (30 ml) was added, 100 ml of water was added, and the pH was adjusted by adding hydrochloric acid and heating to 60¡ãC. After cooling, add water 300ml, extract with methyl tert-butyl ether, take the aqueous layer, adjust the pH with NaOH, extract with n-butanol, wash with water,It was evaporated to dryness to afford 6.30 g of a mixture of the compound of formula I-1 and the compound of formula I-2 in a yield of 92percent.

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Zhejiang Jiuzhou Pharmaceutical Technology Co., Ltd.; Shen Qirong; Yuan Xiangxiang; Gao Hongjun; Li Yuanqiang; (10 pag.)CN107915672; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

652-39-1, A mixture of 3-fluorophthalic anhydride (1 equiv.), 1-amino-3-azabicyclo[4. 1.0]heptane- 2,4-dione (1 equiv.), and potassium acetate (2.5 equiv.) in acetic acid is stirred at 120 ¡ãC overnight. The dark mixture is cooled and filtered. The filter cake is dissolved in DCM and washed with saturated NaHCO3 and brine. The organic layer is dried (Na2504) and concentrated to provide 2-(2,4-dioxo-3 -azabicyclo[4. 1 .0]heptan- 1 -yl)-4-fluoroisoindoline- 1,3 -dione.

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; FITZGERALD, Mark, E.; MICHAEL, Ryan, E.; (790 pag.)WO2017/197056; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

652-39-1, 4-Fluoroisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

652-39-1, General procedure: A 10 mL round bottomed flask was charged with 1 (1.00 mmol), 2 (1.00 mmol), acetic acid (5 mL) and provided with a reflux condenser. The reaction mixture was heated to reflux and stirred for an appropriate period. TLC was used to monitor the progress of the reaction. After completion of the reaction, the mixture was diluted with water (20 mL) and extracted with ethyl acetate (3 x 20 mL). The combined organic layers were washed with water (2 x 20 mL), brine (20 mL), dried over anhydrous Na2SO4, filtered and evaporated in a rotary evaporator under reduced pressure. The crude mixture was purified by column chromatography to afford the pure products (3a-3g?).

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Cheng, Hua; Fu, Yan; Chang, Qing; Zhang, Ni; Bu, Mengwei; Niu, Yan; Wu, Qiongyou; Chen, Cheng; Verpoort, Francis; Chinese Chemical Letters; vol. 29; 12; (2018); p. 1897 – 1900;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

652-39-1, 4-Fluoroisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,652-39-1

In a 50 ml flask was placed 3-Fluorophthalic anhydride (1.0 g, 6 mmol) and aqueous NH3 (1.6 g, 24 mmol). The mixture was heated to 280 0C within 30 minutes and then the flask was cooled to room temperature. 0.93 g of compound 13 were isolated as a yellow solid. LC-MS (ESI, positive): 166 [M+H]+.

The synthetic route of 652-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PHENOMIX CORPORATION; WO2008/86161; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

To a solution of 4-fluoroisobenzofuran-1,3-dione (661 mg, 3.98 mmol, CAS652-39-1), KOAc (1.21 g, 12.3 mmol) in HOAc (30 mL) was added 3-aminopiperidin-2-one (0.50 g, 4.38 mmol CAS1892-22-4). Then the mixture was stirred at 90 C. for 16 hours. On completion, the mixture was concentrated in vacuo to give a residue, which was then diluted with water 60 mL, and filtered to give the filter cake (0.60 g, 57% yield) as yellow solid. 1H NMR (400 MHz, DMSO-d6) delta 7.97-7.86 (m, 2H), 7.79-7.66 (m, 2H), 4.60 (dd, J=6.4, 12.0 Hz, 1H), 3.26-3.14 (m, 2H), 2.27-2.13 (m, 1H), 2.06-1.96 (m, 1H), 1.95-1.86 (m, 2H).

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019/192668; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

652-39-1, 4-Fluoroisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 3-fluorophthalic anhydride (1 equiv.), 6-amino-1,2-thiazinan-3-one 1,1- dioxide (1 equiv.), and potassium acetate (2.5 equiv.) in acetic acid is stirred at 120 ¡ãC overnight. The dark mixture is cooled and filtered. The filter cake is dissolved in DCM and washed with saturated NaHCO3 and brine. The organic layer is dried (Na2SO4) and concentrated to provide 4-fluoro-2? -sulfonyl-thalidomide.

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; FITZGERALD, Mark, E.; MICHAEL, Ryan, E.; (790 pag.)WO2017/197056; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

General procedure: To substituted phthalic anhydride (1.0 eq.) in 0.5 mL of DMSOwas added 4-aminoquinoline based diamines (1.0 eq.) in a microwavereaction vial. The vessel was sealed with a PTFE cap andheated to 160 ¡ãC for 2 min in a microwave reactor. After completionof the reaction as evident from TLC, the vessel contents werepoured in water (20 mL) and extracted with ethyl acetate(2 30 mL). The organic layers were combined, dried over anhydrous Na2SO4 and concentrated under reduced pressure toyield the crude product which was re-crystallized using absoluteethanol.

The synthetic route of 652-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Rani, Anu; Singh, Amandeep; Gut, Jiri; Rosenthal, Philip J.; Kumar, Vipan; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 150 – 156;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

To methanol (175 mL) was added sodium hydride (3.36g, 60percent dispersion, 84.0 mmol) portionwise at ambient temperature under nitrogen. To the solution was added a solution of 3-fluorophthalic anhydride (5.56g, 33.5 mmol) in methanol (50 mL) dropwise under nitrogen at room temperature. The reaction was then worked-up as described for Example 56A to afford the title compound. The NMR data showed the product to be contaminated with 20percent of the 6-fluoro isomer. The material was used without further purification in the next step. 1H NMR (300 MHz, DMSO-J6) delta ppm 3.79 – 3.84 (two s, 3 H) 7.53 – 7.69 (m, 2 H) 7.76 (ddd, /=15.60, 7.29, 1.53 Hz, 1 H) 13.56 (s, 1 H); MS (+DCIZNH3) m/z 216.0 [M+NH4]+.

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; ABBOTT LABORATORIES; AKRITOPOULOU-ZANZE, Irini; BRAJE, Wilfried; DJURIC, Stevan, W.; WILSON, Noel, S.; TURNER, Sean, C.; KRUGER, Albert, W.; RELO, Ana-Lucia; SHEKHAR, Shashank; WELCH, Dennie, S.; ZHAO, Hongyu; GANDARILLA, Jorge; GASIECKI, Alan, F.; LI, Huanqiu; THOMPSON, Christina, M.; ZHANG, Min; WO2010/135560; (2010); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

652-39-1, 4-Fluoroisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: 5-fluoro-2-methyl-2,3-dihydrophthalazine-1,4-dione and 8-fluoro-2-methyl-2,3-dihydrophthalazine-1,4-dione A mixture of 4-fluoroisobenzofuran-1,3-dione (5.0 g, 30.10 mmol) and methylhydrazine (40percent aq., 3.5 g, 30.10 mmol) in ethanol (100 mL) was heated at reflux for 15 h, at which time LCMS indicated that the reaction had gone to completion. The mixture was concentrated under reduced pressure to give the mixture of title compounds (3.5 g, 60percent yield) (2 : 1 ratio of regioisomers) as a yellow solid. This crude material was used in the next step without further purification. LCMS M/Z (M+H) 195. Step 2: 4-chloro-5-fluoro-2-methylphthalazin-1(2H)-one and 4-chloro-8-fluoro-2-methylphthalazin-1(2H)-one A mixture of 5 or 8-fluoro-2-methyl-2,3-dihydrophthalazine-1,4-dione (3.5 g, 18.03 mmol) in POCl3 (50 mL) was heated at reflux for 15 h, at which time LCMS indicated that the reaction had gone to completion. The mixture was concentrated under reduced pressure, the residue was quenched by addition a saturated aqueous solution of NaHCO3 (100 mL), and then extracted with ethyl acetate (3 x 100 mL). The combined organic extracts were dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by silica gel chromatography (petroleum ether : Ethyl acetate = 5: 1) to give the title compounds (1.2 g, 31percent yield) (2 : 1 ratio of regioisomers) as a white solid. LCMS M/Z (M+H) 213.

The synthetic route of 652-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; COTE, Alexandre; CRAWFORD, Terry; DUPLESSIS, Martin; GOOD, Andrew, Charles; LEBLANC, Yves; MAGNUSON, Steven; NASVESCHUK, Christopher, G.; PASTOR, Richard; ROMERO, F. Anthony; TAYLOR, Alexander, M.; (179 pag.)WO2016/36954; (2016); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem