Tag: 190.1953

Onuchina, O. A. et al. published their research in Pharmaceutical Chemistry Journal in 2006 | CAS: 28241-99-8

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Computed Properties of C11H10O3

Synthesis and pharmacological activity of benzofurylhydroxyureas and benzofurylhydroxamic acids was written by Onuchina, O. A.;Zaitsev, S. A.;Arzamastsev, A. P.;Kalinkina, M. A.;Granik, V. G.. And the article was included in Pharmaceutical Chemistry Journal in 2006.Computed Properties of C11H10O3 This article mentions the following:

A series of benzofuran derivatives of hydroxyurea, e.g. I (R = NH2), and hydroxamic acid, e.g. I (R = Me), has been obtained. Hydroxyureas have been O-alkylated with 3-bromomethyl-4-methylfuroxane. The antiinflammatory and antiulcer properties of these compounds have been investigated. In the experiment, the researchers used many compounds, for example, 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8Computed Properties of C11H10O3).

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Computed Properties of C11H10O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Kukharev, B. F. et al. published their research in Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) in 1997 | CAS: 28241-99-8

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C11H10O3

Synthesis of 5-hydroxy-N-(2-vinyloxyalkyl)indoles from dicarbonyl compounds and vinyloxyalkylamines was written by Kukharev, B. F.;Stankevich, V. K.;Klimenko, G. R.;Lobanova, N. A.. And the article was included in Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) in 1997.Formula: C11H10O3 This article mentions the following:

N-(Vinyloxyalkyl) enamino ketones were obtained by the condensation of vinyloxyalkylamines with acetylacetone or Et acetoacetate. Their subsequent reactions with 1,4-benzoquinone produce the corresponding 5-hydroxy-2-methyl-N-(2-vinyloxyalkyl)indoles in 17-43% yields. The structures of the compounds obtained were confirmed by IR and 1H NMR spectroscopy. In the experiment, the researchers used many compounds, for example, 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8Formula: C11H10O3).

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C11H10O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Mukhanova, T. I. et al. published their research in Khimiko-Farmatsevticheskii Zhurnal in 1993 | CAS: 28241-99-8

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Quality Control of 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone

Effects of solvent on the direction of the Nenitzescu reaction was written by Mukhanova, T. I.;Alekseyeva, L. M.;Kuleshova, Ye. F.;Sheinker, Yu. N.;Granik, V. G.. And the article was included in Khimiko-Farmatsevticheskii Zhurnal in 1993.Quality Control of 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone This article mentions the following:

Nenitzescu heterocyclization reaction of enamino ketones RNHCMe:CHAc (R = H, Me, Ph, 4-MeOC6H4) with p-benzoquinone in AcOH afforded benzofuran I in up to 62% yield, whereas indoles II were obtained in MeNO2 (up to 53% yield). Similar results obtained for RNHCMe:CHBz (R = e.g., H, Me, Ph, benzyl). The mechanism was discussed. In the experiment, the researchers used many compounds, for example, 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8Quality Control of 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone).

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Quality Control of 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Nakanishi, Teruo et al. published their research in Nippon Nogei Kagaku Kaishi in 1969 | CAS: 28241-99-8

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Safety of 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone

Gas chromatographic analysis of benzofuran derivatives was written by Nakanishi, Teruo;Ito, Kiyoshi. And the article was included in Nippon Nogei Kagaku Kaishi in 1969.Safety of 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone This article mentions the following:

Retention times (tr in min) of 53 benzofuran derivatives are given for 3 stationary phases at 140-300°. The columns were: (1) 5% diethylene glycol adipate on Chromosorb W, 3 mm inner diameter × 1.11 m; (2) 20% Apiezon grease L on Neosorb NC, 3 mm inner diameter × 1.11 m; (3) 10% Silicone SE-30 on Chromosorb W, 3 mm inner diameter × 0.74 m. A H flame ionization detector was used in each case. In the experiment, the researchers used many compounds, for example, 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8Safety of 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone).

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Safety of 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Grinev, A. N. et al. published their research in Zhurnal Obshchei Khimii in 1959 | CAS: 28241-99-8

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 28241-99-8

Quinones. XXVI. Condensation of p-quinones with furoylacetic ester, acetylacetone and dibenzoylmethane was written by Grinev, A. N.;Bukhtenko, L. A.;Terent’ev, A. P.. And the article was included in Zhurnal Obshchei Khimii in 1959.SDS of cas: 28241-99-8 This article mentions the following:

To 20.5 g. ZnCl2 in 45 ml. EtOH was added 27.3 g. furoylacetic ester, followed by 10.8 g. p-benzoquinone (I). After 1 hr. at 100-10° there was isolated 0.6 g. benzodifuran, m. 254-5°, and 4 g. 2-furyl-3-carbethoxy-5-hydroxybenzofuran, m. 155-6° (this treated in dioxane with Me2SO4-NaOH gave the 5-methoxy analog, m. 65-5.5°). α-Naphthoquinone in the above condensation gave 2 furyl-3-carbethoxy-5-hydroxynaphthofuran, m. 215-16°; 5-Me ether m. 118-19°. Similarly Ac2CH2 and I gave a low yield of 2,6-dimethyl-3,7-diacetylbenzo[1,2-b;4,5-b’]difuran, m. 248-9°, and 60% 2-methyl-3-acetyl-5-hydroxybenzofuran, m. 234°. If I is gradually extracted into the reaction mixture of Ac2CH2, ZnCl2, absolute EtOH and absolute Et2O, the yield of the last product rises and that of the former product declines to zero. Reaction of Ac2CH2 with α-naphthoquinone in the presence of ZnCl2 as above gave 2-methyl-3-acetyl-5-hydroxynaphthofuran, m. 246-8°. Heating 8 g. 2,3-dichloro-p-benzoquinone with 4.5 g. imine of Ac2CH2 in CHCl3 45 min. gave 2-methyl-3-acetyl-6,7-dichloro-5-hydroxybenzofuran, 90%, m. 256-7°. Reaction of Bz2CH2 with α-naphthoquinone in the presence of ZnCl2 in EtOH gave 10:1 ratio of II, m. 174-5°, and 2-phenyl-3-benzoyl-5-hydroxynaphthofuran, m. 224-5°. The former treated with aqueous dioxane solution of NaOH gave a blue solution which with Me2SO4 gave III, m. 160-60.5°. In the experiment, the researchers used many compounds, for example, 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8SDS of cas: 28241-99-8).

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 28241-99-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Gadaginamath, Guru S. et al. published their research in Synthetic Communications in 2003 | CAS: 28241-99-8

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Product Details of 28241-99-8

Novel one pot synthesis of 3-acetyl-5-hydroxy-2-methylbenzofuran and 3-acetyl-5-hydroxy-2-methylnaphthofuran and synthesis of their derivatives was written by Gadaginamath, Guru S.;Kavali, Rajesh R.;Pujar, Shashikanth R.. And the article was included in Synthetic Communications in 2003.Product Details of 28241-99-8 This article mentions the following:

Benzofurans and naphthofurans have so far been obtained, by using either catalyst or as side products. 3-Acetyl-5-hydroxy-2-methylbenzofuran (I; R = H) and 3-acetyl-5-hydroxy-2-methylnaphthofuran (II; R = H) were formed in quant. yield by the Nenitzescu reaction. Further, I and II (R = H) were converted to their corresponding 5-methoxy/5-methoxycarbonylmethoxy derivatives I and II (R = Me, CH2CO2Me). In the experiment, the researchers used many compounds, for example, 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8Product Details of 28241-99-8).

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Product Details of 28241-99-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Grinev, A. N. et al. published their research in Zhurnal Obshchei Khimii in 1959 | CAS: 28241-99-8

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 28241-99-8

Quinones. XXVI. Condensation of p-quinones with furoylacetic ester, acetylacetone and dibenzoylmethane was written by Grinev, A. N.;Bukhtenko, L. A.;Terent’ev, A. P.. And the article was included in Zhurnal Obshchei Khimii in 1959.SDS of cas: 28241-99-8 This article mentions the following:

To 20.5 g. ZnCl2 in 45 ml. EtOH was added 27.3 g. furoylacetic ester, followed by 10.8 g. p-benzoquinone (I). After 1 hr. at 100-10° there was isolated 0.6 g. benzodifuran, m. 254-5°, and 4 g. 2-furyl-3-carbethoxy-5-hydroxybenzofuran, m. 155-6° (this treated in dioxane with Me2SO4-NaOH gave the 5-methoxy analog, m. 65-5.5°). α-Naphthoquinone in the above condensation gave 2 furyl-3-carbethoxy-5-hydroxynaphthofuran, m. 215-16°; 5-Me ether m. 118-19°. Similarly Ac2CH2 and I gave a low yield of 2,6-dimethyl-3,7-diacetylbenzo[1,2-b;4,5-b’]difuran, m. 248-9°, and 60% 2-methyl-3-acetyl-5-hydroxybenzofuran, m. 234°. If I is gradually extracted into the reaction mixture of Ac2CH2, ZnCl2, absolute EtOH and absolute Et2O, the yield of the last product rises and that of the former product declines to zero. Reaction of Ac2CH2 with α-naphthoquinone in the presence of ZnCl2 as above gave 2-methyl-3-acetyl-5-hydroxynaphthofuran, m. 246-8°. Heating 8 g. 2,3-dichloro-p-benzoquinone with 4.5 g. imine of Ac2CH2 in CHCl3 45 min. gave 2-methyl-3-acetyl-6,7-dichloro-5-hydroxybenzofuran, 90%, m. 256-7°. Reaction of Bz2CH2 with α-naphthoquinone in the presence of ZnCl2 in EtOH gave 10:1 ratio of II, m. 174-5°, and 2-phenyl-3-benzoyl-5-hydroxynaphthofuran, m. 224-5°. The former treated with aqueous dioxane solution of NaOH gave a blue solution which with Me2SO4 gave III, m. 160-60.5°. In the experiment, the researchers used many compounds, for example, 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8SDS of cas: 28241-99-8).

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 28241-99-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Gadaginamath, Guru S. et al. published their research in Synthetic Communications in 2003 | CAS: 28241-99-8

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Product Details of 28241-99-8

Novel one pot synthesis of 3-acetyl-5-hydroxy-2-methylbenzofuran and 3-acetyl-5-hydroxy-2-methylnaphthofuran and synthesis of their derivatives was written by Gadaginamath, Guru S.;Kavali, Rajesh R.;Pujar, Shashikanth R.. And the article was included in Synthetic Communications in 2003.Product Details of 28241-99-8 This article mentions the following:

Benzofurans and naphthofurans have so far been obtained, by using either catalyst or as side products. 3-Acetyl-5-hydroxy-2-methylbenzofuran (I; R = H) and 3-acetyl-5-hydroxy-2-methylnaphthofuran (II; R = H) were formed in quant. yield by the Nenitzescu reaction. Further, I and II (R = H) were converted to their corresponding 5-methoxy/5-methoxycarbonylmethoxy derivatives I and II (R = Me, CH2CO2Me). In the experiment, the researchers used many compounds, for example, 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8Product Details of 28241-99-8).

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Product Details of 28241-99-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem