Tag: 134.132

Anonymous et al. published their research in Research Disclosure in 1975 | CAS: 13196-10-6

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Electric Literature of C8H6O2

Use of compounds in conjunction with fertilizers was written by Anonymous. And the article was included in Research Disclosure in 1975.Electric Literature of C8H6O2 This article mentions the following:

Compounds of the formula I (where R1 to R4 may be the same or different alkyl groups) are used in conjunction with fast or slow acting fertilizers to retard plant growth. Thus, I (R1 = R2 = R4 = Me; R3 = Et [26225-79-6]) was applied either at the same time or 3-4 weeks subsequent to the application of solid or liquid form fertilizers. When applied as a mixture with a slow-release fertilizer the preferred proportion was 15-60 parts by weight of N and 1-4 parts I. In the experiment, the researchers used many compounds, for example, Benzofuran-5-ol (cas: 13196-10-6Electric Literature of C8H6O2).

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Electric Literature of C8H6O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cainelli, Mauro et al. published their research in International Research Journal of Pure and Applied Chemistry in 2016 | CAS: 13196-10-6

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Name: Benzofuran-5-ol

A theoretical study of 2-nitrofuran vs 3-nitrofuran as dienophilic electrophile in polar cycloaddition reaction: comparison of the reactivity and reaction mechanism was written by Cainelli, Mauro;Ormachea, Carla M.;Mancini, Pedro M. E.;Kneeteman, Maria N.. And the article was included in International Research Journal of Pure and Applied Chemistry in 2016.Name: Benzofuran-5-ol This article mentions the following:

In this study, we analyzed in a theor. form the behavior of 2-nitrofuran and 3-nitrofuran acting as dienophilic electrophiles in polar cycloaddition reactions joint to different dienes. The reactivity and regioselectivity was discussed employing global and local reactivity indexes, resp. The reaction mechanisms of these cycloadditions were compared through the transition state structures and energies calculated In the experiment, the researchers used many compounds, for example, Benzofuran-5-ol (cas: 13196-10-6Name: Benzofuran-5-ol).

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Name: Benzofuran-5-ol

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Sridhar, Arunasalam et al. published their research in New Journal of Chemistry in 2019 | CAS: 13196-10-6

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.HPLC of Formula: 13196-10-6

Polymer-supported eosin Y as a reusable photocatalyst for visible light mediated organic transformations was written by Sridhar, Arunasalam;Rangasamy, Rajmohan;Selvaraj, Mari. And the article was included in New Journal of Chemistry in 2019.HPLC of Formula: 13196-10-6 This article mentions the following:

A novel polymer-supported recyclable photocatalyst was developed for visible light mediated oxidation reactions. The organic dye eosin Y was loaded on macroporous com. available Amberlite IRA 900 chloride resin and exploited as a photocatalyst for visible light mediated oxidation of thioethers to sulfoxides and phenylboronic acids to phenols under open atm. air. Varieties of functional groups were well tolerated during oxidation The catalyst is recyclable for six cycles without significant loss in its efficiency. Furthermore, gram-scale oxidation of sulfides to sulfoxides was demonstrated to prove the com. viability of the method. In the experiment, the researchers used many compounds, for example, Benzofuran-5-ol (cas: 13196-10-6HPLC of Formula: 13196-10-6).

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.HPLC of Formula: 13196-10-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Smyth, Lynette A. et al. published their research in Journal of Organic Chemistry in 2016 | CAS: 13196-10-6

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Application In Synthesis of Benzofuran-5-ol

Pd-Catalyzed Synthesis of Aryl and Heteroaryl Triflones from Reactions of Sodium Triflinate with Aryl (Heteroaryl) Triflates was written by Smyth, Lynette A.;Phillips, Eric M.;Chan, Vincent S.;Napolitano, Jose G.;Henry, Rodger;Shekhar, Shashank. And the article was included in Journal of Organic Chemistry in 2016.Application In Synthesis of Benzofuran-5-ol This article mentions the following:

A novel method for Pd-catalyzed triflination of aryl and heteroaryl triflates using NaSO2CF3 as the nucleophile is described. The combination of Pd2(dba)3 and RockPhos formed the most effective catalyst. A broad range of functional groups and heteroaromatic compounds were tolerated under the neutral reaction conditions. The order of reactivity ArOTf ≥ ArCl ≥ ArBr is consistent with transmetalation being a slow step of the reaction. In the experiment, the researchers used many compounds, for example, Benzofuran-5-ol (cas: 13196-10-6Application In Synthesis of Benzofuran-5-ol).

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Application In Synthesis of Benzofuran-5-ol

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Saha, Ashis K. et al. published their research in ACS Medicinal Chemistry Letters in 2011 | CAS: 13196-10-6

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Formula: C8H6O2

Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS was written by Saha, Ashis K.;Yu, Xiang;Lin, Jian;Lobera, Mercedes;Sharadendu, Anurag;Chereku, Srinivas;Schutz, Nili;Segal, Dalia;Marantz, Yael;McCauley, Dilara;Middleton, Scot;Siu, Jerry;Burli, Roland W.;Buys, Janet;Horner, Michelle;Salyers, Kevin;Schrag, Michael;Vargas, Hugo M.;Xu, Yang;McElvain, Michele;Xu, Han. And the article was included in ACS Medicinal Chemistry Letters in 2011.Formula: C8H6O2 This article mentions the following:

Novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity were prepared 1-{[4-(5-Benzylbenzofuran-2-yl)-3-fluorophenyl]methyl}azetidine-3-carboxylic acid is a potent S1P1 agonist with >1000× selectivity over S1P3. It demonstrated a good in vitro ADME profile and excellent oral bioavailability across species. Dosed orally at 0.3 mg/kg, I significantly reduced blood lymphocyte counts 24 h postdose and demonstrated efficacy in a mouse EAE model of relapsing MS. In the experiment, the researchers used many compounds, for example, Benzofuran-5-ol (cas: 13196-10-6Formula: C8H6O2).

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Formula: C8H6O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Saha, Ashis K. et al. published their research in ACS Medicinal Chemistry Letters in 2011 | CAS: 13196-10-6

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Formula: C8H6O2

Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS was written by Saha, Ashis K.;Yu, Xiang;Lin, Jian;Lobera, Mercedes;Sharadendu, Anurag;Chereku, Srinivas;Schutz, Nili;Segal, Dalia;Marantz, Yael;McCauley, Dilara;Middleton, Scot;Siu, Jerry;Burli, Roland W.;Buys, Janet;Horner, Michelle;Salyers, Kevin;Schrag, Michael;Vargas, Hugo M.;Xu, Yang;McElvain, Michele;Xu, Han. And the article was included in ACS Medicinal Chemistry Letters in 2011.Formula: C8H6O2 This article mentions the following:

Novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity were prepared 1-{[4-(5-Benzylbenzofuran-2-yl)-3-fluorophenyl]methyl}azetidine-3-carboxylic acid is a potent S1P1 agonist with >1000× selectivity over S1P3. It demonstrated a good in vitro ADME profile and excellent oral bioavailability across species. Dosed orally at 0.3 mg/kg, I significantly reduced blood lymphocyte counts 24 h postdose and demonstrated efficacy in a mouse EAE model of relapsing MS. In the experiment, the researchers used many compounds, for example, Benzofuran-5-ol (cas: 13196-10-6Formula: C8H6O2).

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Formula: C8H6O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Andrew, Michael et al. published their research in Synthesis in 1999 | CAS: 13196-10-6

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Synthetic Route of C8H6O2

A convenient synthetic route to 7,8-fused heterocyclic ring derivatives of (S)-2,3-dihydro-1,4-benzodioxin-2-methanol was written by Andrew, Michael;Birch, Alan M.;Bradley, Paul A.. And the article was included in Synthesis in 1999.Synthetic Route of C8H6O2 This article mentions the following:

A much improved synthesis of (S)-2,3-dihydro-7H-1,4-dioxino[2,3-e]indole-2-methanol is described, which is shorter, higher-yielding, and less hazardous than the previous synthesis of its racemic form. This novel procedure allows preparation of multigram quantities of the enantiomerically pure compound Application of this methodol. to different 5-hydroxy heterocycles enables access to furo[3,2-f][1,4]benzodioxins, thieno[3,2-f][1,4]benzodioxins, and 1,4-dioxino[2,3-e]indazoles. In the experiment, the researchers used many compounds, for example, Benzofuran-5-ol (cas: 13196-10-6Synthetic Route of C8H6O2).

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Synthetic Route of C8H6O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Huang, Jian et al. published their research in Proceedings of the National Academy of Sciences of the United States of America in 2021 | CAS: 13196-10-6

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Quality Control of Benzofuran-5-ol

Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents was written by Huang, Jian;Yuan, Yafei;Zhao, Na;Pu, Debing;Tang, Qingxuan;Zhang, Shuo;Luo, Shuchen;Yang, Xikang;Wang, Nan;Xiao, Yu;Zhang, Tuan;Liu, Zhuoyi;Sakata-Kato, Tomoyo;Jiang, Xin;Kato, Nobutaka;Yan, Nieng;Yin, Hang. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2021.Quality Control of Benzofuran-5-ol This article mentions the following:

Artemisinin-resistant malaria parasites have emerged and have been spreading, posing a significant public health challenge. Antimalarial drugs with novel mechanisms of action are therefore urgently needed. In this report, we exploit a ‘selective starvation’ strategy by inhibiting Plasmodium falciparum hexose transporter 1 (PfHT1), the sole hexose transporter in P. falciparum, over human glucose transporter 1 (hGLUT1), providing an alternative approach to fight against multidrug-resistant malaria parasites. The crystal structure of hGLUT3, which shares 80% sequence similarity with hGLUT1, was resolved in complex with C3361, a moderate PfHT1-specific inhibitor, at 2.3-Å resolution Structural comparison between the present hGLUT3-C3361 and our previously reported PfHT1-C3361 confirmed the unique inhibitor binding-induced pocket in PfHT1. We then designed small mols. to simultaneously block the orthosteric and allosteric pockets of PfHT1. Through extensive structure-activity relationship studies, the TH-PF series was identified to selectively inhibit PfHT1 over hGLUT1 and potent against multiple strains of the blood-stage P. falciparum. Our findings shed light on the next-generation chemotherapeutics with a paradigm-shifting structure-based design strategy to simultaneously target the orthosteric and allosteric sites of a transporter. In the experiment, the researchers used many compounds, for example, Benzofuran-5-ol (cas: 13196-10-6Quality Control of Benzofuran-5-ol).

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Quality Control of Benzofuran-5-ol

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Huang, Jian et al. published their research in Proceedings of the National Academy of Sciences of the United States of America in 2021 | CAS: 13196-10-6

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Quality Control of Benzofuran-5-ol

Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents was written by Huang, Jian;Yuan, Yafei;Zhao, Na;Pu, Debing;Tang, Qingxuan;Zhang, Shuo;Luo, Shuchen;Yang, Xikang;Wang, Nan;Xiao, Yu;Zhang, Tuan;Liu, Zhuoyi;Sakata-Kato, Tomoyo;Jiang, Xin;Kato, Nobutaka;Yan, Nieng;Yin, Hang. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2021.Quality Control of Benzofuran-5-ol This article mentions the following:

Artemisinin-resistant malaria parasites have emerged and have been spreading, posing a significant public health challenge. Antimalarial drugs with novel mechanisms of action are therefore urgently needed. In this report, we exploit a ‘selective starvation’ strategy by inhibiting Plasmodium falciparum hexose transporter 1 (PfHT1), the sole hexose transporter in P. falciparum, over human glucose transporter 1 (hGLUT1), providing an alternative approach to fight against multidrug-resistant malaria parasites. The crystal structure of hGLUT3, which shares 80% sequence similarity with hGLUT1, was resolved in complex with C3361, a moderate PfHT1-specific inhibitor, at 2.3-Å resolution Structural comparison between the present hGLUT3-C3361 and our previously reported PfHT1-C3361 confirmed the unique inhibitor binding-induced pocket in PfHT1. We then designed small mols. to simultaneously block the orthosteric and allosteric pockets of PfHT1. Through extensive structure-activity relationship studies, the TH-PF series was identified to selectively inhibit PfHT1 over hGLUT1 and potent against multiple strains of the blood-stage P. falciparum. Our findings shed light on the next-generation chemotherapeutics with a paradigm-shifting structure-based design strategy to simultaneously target the orthosteric and allosteric sites of a transporter. In the experiment, the researchers used many compounds, for example, Benzofuran-5-ol (cas: 13196-10-6Quality Control of Benzofuran-5-ol).

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Quality Control of Benzofuran-5-ol

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem