CC-1065 Analogues Bearing Different DNA-Binding Subunits: Synthesis, Antitumor Activity, and Preliminary Toxicity Study was written by Wang, Yuqiang;Li, Lianfa;Ye, Wenqing;Tian, Zhiming;Jiang, Wei;Wang, Hong;Wright, Susan C.;Larrick, James W.. And the article was included in Journal of Medicinal Chemistry in 2003.Name: 5-Fluorobenzofuran-2-carboxylic acid This article mentions the following:
CC-1065 analogs bearing different DNA-binding subunits were synthesized. A terminal C5-NO2 and -F moiety at the DNA-binding subunit increased the drug’s potency and antitumor efficacy. A C5-OCH3 reduced the potency and antitumor efficacy. Compound (±)-I, bearing a trans double bond, had increased antitumor efficacy. A preliminary toxicity study indicated that terminal C5-OCH3 and -acetamido moieties at the DNA-binding subunit caused delayed death in mice. In the experiment, the researchers used many compounds, for example, 5-Fluorobenzofuran-2-carboxylic acid (cas: 89197-62-6Name: 5-Fluorobenzofuran-2-carboxylic acid).
5-Fluorobenzofuran-2-carboxylic acid (cas: 89197-62-6) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Name: 5-Fluorobenzofuran-2-carboxylic acid
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem