Chen, Shang-Ke’s team published research in Bioorganic & Medicinal Chemistry Letters in 22 | CAS: 56317-21-6

Bioorganic & Medicinal Chemistry Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Application In Synthesis of 56317-21-6.

Chen, Shang-Ke published the artcileMoracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor, Application In Synthesis of 56317-21-6, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(9), 3261-3264, database is CAplus and MEDLINE.

Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma. Moracin M extracted from Chinese herbal drug ‘Sang-Bai-Pi’ (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC50 values of 2.9, 4.5, >40, and >100 μM, resp. Our mol. docking and 8 ns mol. dynamics (MD) simulations demonstrated that moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics anal. of its analog moracin C was carried out to qual. validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations.

Bioorganic & Medicinal Chemistry Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Application In Synthesis of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Jing, Ying’s team published research in Tianran Chanwu Yanjiu Yu Kaifa in 22 | CAS: 56317-21-6

Tianran Chanwu Yanjiu Yu Kaifa published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Category: benzofurans.

Jing, Ying published the artcileChemical constituents from the leaves of Morus mongolica, Category: benzofurans, the publication is Tianran Chanwu Yanjiu Yu Kaifa (2010), 22(2), 181-184, database is CAplus.

Chem. constituents of the leaves of Morus mongolica were isolated and purified by ion-exchange resin, silica gel, ODS and Sephadex LH-20 column chromatogs. Their structures were elucidated on the basis of physico-chem. properties and spectral data. Ten compounds were identified as 1-deoxynojirimycin (1), fagomine (2), myoinositol (3), moracin M (4), 3-O-β-D-glucopyranoside (5), umbelliferone (6), scopoletin (7), syringaresinol (8), 2,4,2′,4′-tetrahydroxychalcone (9), and daucosterol (10), resp. Compounds 2, 3, 5-10 were isolated from this plant for the first time, and compound 9 is a new natural product.

Tianran Chanwu Yanjiu Yu Kaifa published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Category: benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Yang, Pei-Song’s team published research in Heterocycles in 92 | CAS: 56317-21-6

Heterocycles published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C15H20BNO3, SDS of cas: 56317-21-6.

Yang, Pei-Song published the artcileTwo new 2-arylbenzofurans from the stems of Nicotiana tabacum and their bioactivities, SDS of cas: 56317-21-6, the publication is Heterocycles (2016), 92(8), 1462-1467, database is CAplus.

Two new 2-arylbenzofurans, 4-(7-methoxy-3,5-dimethyl-benzofuran-2-yl)phenol (1), 4-(6-methoxy-3,5-dimethylbenzofuran-2-yl)-phenol (2), together with two known 2-arylbenzofurans (3 and 4) were isolated from the stems of Nicotiana tabacum. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-4 were tested for their anti-TMV and cytotoxicity activities. The results showed that compound 2 exhibited high anti-TMV activities with inhibition rates of 36.4% at the concentration of 20 μM. This rate is higher than that of pos. control. Compounds 1-4 showed moderate-to-weak cytotoxicities against some tested human tumor cell lines with IC50 values in the range of 2.2-8.4 μM.

Heterocycles published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C15H20BNO3, SDS of cas: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zhang, Hua’s team published research in Organic Letters in 22 | CAS: 69626-75-1

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C10H19NO3, Formula: C8H5IO.

Zhang, Hua published the artcileA Construction of α-Alkenyl Lactones via Reduction Radical Cascade Reaction of Allyl Alcohols and Acetylenic Acids, Formula: C8H5IO, the publication is Organic Letters (2020), 22(21), 8337-8344, database is CAplus and MEDLINE.

An iron-catalyzed cascade reaction of radical reduction of allyl alcs. and acetylenic acids to construct polysubstituted α-alkenyl lactones has been developed. In this paper, various allyl alcs. can form allyl ester intermediates and are further transformed into alkyl radicals, which form products through intramol. reflex-Michael addition In addition, this method can be used to prepare spirocycloalkenyl lactones. Interestingly, this protocol can be used to synthesize the skeleton structure of natural products. Moreover, the product can be further transformed into a β-methylene THF and THF diene.

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C10H19NO3, Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Xu, Tianlong’s team published research in Journal of Organic Chemistry in 80 | CAS: 56317-21-6

Journal of Organic Chemistry published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C10H7NO3, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Xu, Tianlong published the artcileCu-Catalyzed Consecutive Hydroxylation and Aerobic Oxidative Cycloetherification under Microwave Conditions: Entry to 2-Arylbenzofuran-3-carboxylic Acids, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Journal of Organic Chemistry (2015), 80(9), 4313-4324, database is CAplus and MEDLINE.

A convenient one-pot synthesis of 2-arylbenzofuran-3-carboxylic acids from (E)-2-(2-bromophenyl)-3-phenylacrylic acids via Cu-catalyzed consecutive hydroxylation and aerobic oxidative cycloetherification under microwave conditions has been developed. This protocol employed the reagent combination of Cu(OAc)2, 1,10-phen, and KOH in DMSO/H2O (1:1), all of which are cost-effective, readily available, and easily removable from the reaction mixture Utilizing this synthetic protocol, various 2-arylbenzofuran-3-carboxylic acids as well as the natural product moracin M have been synthesized in satisfactory yields under mild conditions.

Journal of Organic Chemistry published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C10H7NO3, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Celaje, Jeff A.’s team published research in Organic Letters in 13 | CAS: 56317-21-6

Organic Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, HPLC of Formula: 56317-21-6.

Celaje, Jeff A. published the artcileChemistry of trans-Resveratrol with Singlet Oxygen: [2 + 2] Addition, [4 + 2] Addition, and Formation of the Phytoalexin Moracin M, HPLC of Formula: 56317-21-6, the publication is Organic Letters (2011), 13(18), 4846-4849, database is CAplus and MEDLINE.

Resveratrol reacts with singlet oxygen by two major pathways: A [2 + 2] cycloaddition forming a transient dioxetane that cleaves into the corresponding aldehydes and a [4 + 2] cycloaddition forming an endoperoxide that, upon heating, undergoes a rearrangement to moracin M. The rate constant by which singlet oxygen is removed by resveratrol (kT) was determined by time-resolved IR luminescence spectroscopy to be 1.5 × 106 M-1 sec-1 in CD3OD, smaller than previously reported values. Chem. reaction accounts for ca. 25% of kT.

Organic Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, HPLC of Formula: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Hou, Zhen-Lin’s team published research in Organic Letters in 22 | CAS: 69626-75-1

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, COA of Formula: C8H5IO.

Hou, Zhen-Lin published the artcilePeptide modification via N-terminal-residue-directed γ-C(sp3)-H arylation, COA of Formula: C8H5IO, the publication is Organic Letters (2020), 22(21), 8692-8696, database is CAplus and MEDLINE.

Post-assembly modification of peptides via C(sp3)-H functionalization provides an efficient way to prepare functionalized peptides for biol. study and pharmaceutical development. In this work, we developed a new method for γ-C(sp3)-H functionalization of aliphatic side chains of N-terminus-unprotected peptides. With the N-terminal residues as directing groups, a wide range of di-, tri-, tetra-, and pentapeptides underwent C-H arylation of the residues (Val, Ile, Tle) at the +2 position from the N-terminus.

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, COA of Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Hosoi, Kazuo’s team published research in Journal of Biochemistry in 74 | CAS: 596-01-0

Journal of Biochemistry published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Application In Synthesis of 596-01-0.

Hosoi, Kazuo published the artcileCompetition between P1 [inorganic orthophosphate] and pH indictors in photosynthetic ATP formation in chromatophores of Rhodospirillum rubrum, Application In Synthesis of 596-01-0, the publication is Journal of Biochemistry (1973), 74(6), 1275-8, database is CAplus and MEDLINE.

The effects of 8 different pH indicators on the activities for ATP formation in the light and for ATP-Pi exchange in the dark in chromatophores from a carotenoidless mutant (G-9) of R. rubrum were studied. The ratio of the amount of dye bound to chromatophores to the total amount of dye added to the mixture were constant at appropriate concentrations Neither added ATP nor illumination influenced the amount of dye bound with chromatophores. Concentrations of 0.1mM α-naphtholphthalein and Bromcresol Green inhibited the activity for ATP formation and the ATP-Pi exchange but the bindings with chromatophores were ∼78% and 18%, resp., indicating that the binding of pH indicators was not essential for the inhibitions.

Journal of Biochemistry published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Application In Synthesis of 596-01-0.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Wu, Chunlin’s team published research in Angewandte Chemie, International Edition in 57 | CAS: 69626-75-1

Angewandte Chemie, International Edition published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C15H21BO2, Computed Properties of 69626-75-1.

Wu, Chunlin published the artcileCobalt-Catalyzed Intramolecular Reactions between a Vinylcyclopropane and an Alkyne: Switchable [5+2] Cycloaddition and Homo-Ene Pathways, Computed Properties of 69626-75-1, the publication is Angewandte Chemie, International Edition (2018), 57(22), 6558-6562, database is CAplus and MEDLINE.

Cobalt-diphosphine catalysts have been found to promote intramol. reactions between a vinylcyclopropane and an alkyne to selectively afford either the [5+2] cycloaddition product or the homo-ene reaction product under solvent control. The former product is exclusively formed in noncoordinating 1,2-dichloroethane, whereas the latter is dominant in coordinating solvents, such as acetonitrile and dimethylacetamide. Furthermore, a highly enantioselective variant of the homo-ene reaction afforded chiral THF, pyrrolidine, and cyclopentane derivatives bearing 1,3-diene and alkylidene substituents. Thus, e.g., cycloaddition of I afforded II (85%) in presence of CoI2, dppp, Zn and ZnI2 in DCE, whereas the same catalytic system exclusively afforded homo-ene product III (86%) in NMP.

Angewandte Chemie, International Edition published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C15H21BO2, Computed Properties of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Blevins, David W.’s team published research in Tetrahedron Letters in 56 | CAS: 69626-75-1

Tetrahedron Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Product Details of C8H5IO.

Blevins, David W. published the artcileIododemetallation of potassium organotrifluoroborates and tributylarylstannanes using sodium iodide/iron(III) chloride, Product Details of C8H5IO, the publication is Tetrahedron Letters (2015), 56(23), 3130-3132, database is CAplus.

A combinative iron(III) chloride/sodium iodide system was found to be very efficient for the iododemetallation of both organotrifluoroborates and tributyl(aryl)stannanes. A variety of functional groups tolerate the mild reaction conditions.

Tetrahedron Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Product Details of C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem