Brief introduction of 79002-39-4

The synthetic route of 79002-39-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79002-39-4,Benzofuran-5-carbonitrile,as a common compound, the synthetic route is as follows.

79002-39-4, EXAMPLE 20 Preparation of 1-benzofuran-5-carbaldehyde To a solution of 1-benzofuran-5-carbonitrile (5.0 g, 34.9 mmol) in CH2Cl2 under nitrogen at -15 to -20 C. was added DIBAL-H (41.9 mL, 41.9 mmol, 1 M/heptane) and the temperature was maintained below -15 C. After addition was complete, the reaction mixture was stirred at -15 to -20 C. for an additional 10 min. The reaction mixture was quenched via dropwise addition of aqueous 2N HCl. The organic layer was separated and washed with water, dried over sodium sulfate, and concentrated to give 4.0 g (78%) of 1-benzofuran-5-carbaldehyde as a yellow oil.

The synthetic route of 79002-39-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Cole, Derek Cecil; Asselin, Magda; Boschelli, Diane Harris; Wissner, Allan; Wang, Yanong Daniel; Prashad, Amarnauth Shastrie; Dushin, Russell; US2007/287738; (2007); A1;,
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Brief introduction of 6940-49-4

6940-49-4 3-Bromophthalide 96218, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6940-49-4,3-Bromophthalide,as a common compound, the synthetic route is as follows.

Next, 0.75 g (2.0 mmol) of the compound of the structural formula (3), 0.64 g (3.0 mmol) of 3-bromophthalide and 10 ml of acetonitrile were placed in a 100 ml recovery flask, and the mixture was stirred at 70 C. for 6 hours under a nitrogen stream went. After completion of the reaction, the precipitated crystals were filtered and washed with acetonitrile to obtain 0.83 g (yield: 70%) of halide (I, Br mixed) of exemplified compound A-4. Next, an aqueous solution of 0.41 g (2.5 mmol) of ammonium hexafluorophosphate was added dropwise to an aqueous solution of 0.5 g (0.84 mmol) of the halogen compound of exemplified compound A-4 and stirred for 2 hours. After completion of the reaction, the precipitated white crystals were filtered, washed with water and dried at room temperature under reduced pressure to obtain 0.40 g (yield 70%) of exemplified compound A-4., 6940-49-4

6940-49-4 3-Bromophthalide 96218, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; CANON INCORPORATED; TAMURA, TETSUYA; IGAWA, SATOSHI; YAMADA, KENJI; (27 pag.)JP2017/197477; (2017); A;,
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New learning discoveries about 77095-51-3

The synthetic route of 77095-51-3 has been constantly updated, and we look forward to future research findings.

77095-51-3, Benzofuran-6-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

77095-51-3, Add HATU (418 mg, 1.1 mmol) and DIPEA (390 mg, 3 mmol) to a vigorously stirred solution of benzofuran-6-carboxylic acid (178 mg, 1.1 mmol) in DMF (5 mL). After the reaction mixture was reacted at room temperature for 1 hour, (S)-2-(8-chloro-2,3-dihydro-1H-pyrrole[3,2,1-ij]-quinazoline-7-carbonylamino)- 3-(3-(Methanesulfonyl)phenyl)propanoic acid benzyl ester trifluoroacetate (649 mg, 1 mmol), the mixture was stirred at room temperature for 2 hours. Ethyl acetate was added (100 mL), sequentially washed with water (20mL), saturated brine (20mL) was washed, and the organic phase was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated, the residue was purified by flash chromatography, Petroleum ether with 50% ethyl acetate in hexanes to afford the desired product as a white solid (661mg, 0.95mmol 95%).

The synthetic route of 77095-51-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Weimou Bio-technology (Shanghai) Co., Ltd.; Shen Wang; Ding Yue; Wang Jiangfeng; Jiang Hao; Chen Fuli; Wu Xinglong; Li Cunfei; Yang Liguo; Hu Biao; (34 pag.)CN109721605; (2019); A;,
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Simple exploration of 24673-56-1

24673-56-1 3-Methylbenzofuran-2-carboxylic acid 600591, abenzofuran compound, is more and more widely used in various fields.

24673-56-1, 3-Methylbenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3-methyl-benzofuran-2-carboxylic acid (0.98 g, 5.6 mmol) and catalytic amount of DMF (5 drops) in THF (25 ml) was added oxalyl chloride (0.53 ml, 6.1 mmol). After stirring the solution for 1 h at room temperature, methanol (20 ml) and TEA (7.0 ml) were added. The reaction mixture was stirred overnight at room temperature, then concentrated and dissolved in ethyl acetate (100 ml) and washed with aqueous sodium bicarbonate solution (100 ml). The organic layer was dried over sodium sulfate and concentrated to provide crude methyl 3-methylbenzofuran-2-carboxylate (1.0 g, 5.3 mmol) as a tan solid, which was used without further purification., 24673-56-1

24673-56-1 3-Methylbenzofuran-2-carboxylic acid 600591, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; AXYS PHARMACEUTICALS, INC.; WO2005/19174; (2005); A1;,
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Simple exploration of 32703-79-0

32703-79-0, The synthetic route of 32703-79-0 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32703-79-0,5-(tert-Butyl)isobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

A solution of amine salt 1-127 (36 mg, 0.117 mmol), 5-(/er/-butyl)isobenzofuran- l,3-dione (29 mg, 1.2 equiv.) and potassium acetate (11 mg, 1.0 equiv.) in AcOH was heated to 100 C for 18 hours. The reaction mixture was then cooled to ambient temperature and concentrated in vacuo. The residue was dissolved in EtOAc and the solution was washed with 1 M HC1 then brine, and the combined aqueous washes were back-extracted with EtOAc. The combined organic extracts were dried over sodium sulfate and concentrated in vacuo. The resulting residue was purified by flash chromatography using 15% MeOH in DCM with 1% AcOH to afford 49 mg of intermediate acid 1-138 containing dicarboxylic acid impurities. This material was dissolved in DCM along with pentafluorophenol (18.4 mg, 0.100 mmol) and EDC (19 mg, 0.100 mmol). The resulting reaction mixture was stirred for 2 hours, concentrated in vacuo , and the residue was re- dissolved in EtOAc. The resulting solution was washed with 1 M HC1 and brine, dried over sodium sulfate, and concentrated in vacuo. Purification of the residue by flash chromatography using EtOAc in hexanes afforded 22 mg of 1-139 (37% yield over two steps).

32703-79-0, The synthetic route of 32703-79-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CARMOT THERAPEUTICS, INC.; ENQUIST, Johan; KRISHNAN, Shyam; ATWAL, Suman; ERLANSON, Daniel; FUCINI, Raymond V.; HANSEN, Stig; SAWAYAMA, Andrew; SETHOFER, Steven; (719 pag.)WO2019/183577; (2019); A1;,
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Brief introduction of 10242-10-1

10242-10-1, The synthetic route of 10242-10-1 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-10-1,5-Chlorobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a stirred solution of tert-butyl 4-aminopiperidine-l-carboxylate (1.02 g, 5.10 mmol, 1.0 equiv) in DMF (10 mL) was added 5-chlorobenzofuran-2 -carboxylic acid (1 .0 g, 5.1 mmol, 1.0 equiv) and HATU (3.800 g, 10.02 mmol, 2.0 equiv) at RT. The resulting reaction mixture was stirred for 10 minutes and DIPEA (2.5 mL, 15.00 mmol, 3.00 equiv) was added. The reaction mixture was allowed to stir at RT for overnight. Product formation was confirmed by LCMS. The reaction mixture was diluted with water (50 mL) and extracted with ethyl acetate (100 mL c 2). Combined organic extracts were washed with water (20 mL *4), dried over anhydrous NaaSOr and concentrated. The crude product obtained was treated w ith ether- hexane (50:50) to obtain tert-butyl 4-(5-chlorobenzofuran-2-carboxaniido)piperidine-1 – carboxylate (0.800 g, 43% yield) as an off-white solid. LCMS: 379.2 [M+H] 2

10242-10-1, The synthetic route of 10242-10-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PRAXIS BIOTECH LLC; DELGADO OYARZO, Luz Marina; URETA DIAZ, Gonzalo Andres; PUJALA, Brahmam; PANPATIL, Dayanand; BERNALES, Sebastian; CHAKRAVARTY, Sarvajit; (0 pag.)WO2019/236710; (2019); A1;,
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Analyzing the synthesis route of 496-16-2

As the paragraph descriping shows that 496-16-2 is playing an increasingly important role.

496-16-2, 2,3-Dihydrobenzo[b]furan is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a. Preparation of 2,3-dihydrobenzo[b]furan-7-carboxylic acid (15a) To a solution of n-BuLi (1.7 M, 123 ml, 0.21 mol) in 400 ml of hexane at room temperature was added 24.3 g (0.21 mol) of N,N,N’,N’-tetramethylethylenediamine (TMEDA), followed by a hexane (40 ml) solution of 2,3-dihydrobenzo[b]furan (14) (12.56 g, 0.11 mol). The mixture was stirred under argon at room temperature for 4 hours, and then poured into dry ice (pre-washing with anhydrous ether). After stirring at ambient temperature overnight, the mixture was diluted with water (300 ml), and the layers separated. The aqueous layer was acidified with conc. HCl to pH 1, cooled and the precipitate collected on a filter. This was recrystallized from CH2Cl2 to give 15a (9.43 g, 54.7%) as a white solid, mp 167-169.5C., 496-16-2

As the paragraph descriping shows that 496-16-2 is playing an increasingly important role.

Reference£º
Patent; Erbamont Inc.; EP234872; (1991); B1;,
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Brief introduction of 50551-63-8

As the paragraph descriping shows that 50551-63-8 is playing an increasingly important role.

50551-63-8,50551-63-8, 6-Methoxybenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 207 To a solution of 6-methoxybenzofuran (16.9 g) in collidine (200 ml) was added lithium iodide (30.5 g), and the mixture was refluxed under argon atmosphere for 1 day and cooled. To the mixture was added 1N hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with 2N hydrochloric acid (5 times) and then washed with water and saturated brine, and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated, and the residue was purified with silica gel column chromatography to give dark brown oil of 6-hydroxybenzofuran (2.9 g). 1H-NMR (200 MHz, CDCl3) delta 8 5.04 (s, 1H), 6.69 (dd, 1H, J=2.6, 1.0 Hz), 6.79 (dd, 1H, J=8.4, 2.2 Hz), 7.00 (d, 1H, J=2.0 Hz), 7.42 (d, 1H, J=8.4 Hz), 7.52 (d, 1H, J=2.2 Hz).

As the paragraph descriping shows that 50551-63-8 is playing an increasingly important role.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US6235771; (2001); B1;,
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Brief introduction of 127264-14-6

The synthetic route of 127264-14-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

2,2-Diphenyl-2-pyrrolidin-3-yl-acetamide (2, 2.8 g, 0.01 mol) and 5-(2-bromoethyl)-2,3-dihydrobenzofuran (3, 4.54 g, 0.02 mol) were refluxed in acetone (70 mL) containing K2CO3 (2.76 g, 0.02 mol). After completion of the reaction mass was concentrated under vacuum and the obtained residue was poured into water. The separated solid was filtered and dried. The crude product was purified over silica gel column using MDC: MeOH (99:1 to 96:4) as eluent to obtain product in 4 g yield. IR (KBr): 3220, 3056, 2946, 2856, 1698, 1614, 1491, 1443, 1359, 1243, 1219, 1101, 1076, 814, 752,701 cm-1; 1H MNR (300 MHz, CDCl3): delta 0.68 (m, 1H), 1.40-1.44 (m, 1H), 2.41-2.61 (m, 2H), 2.41-2.61 (m, 2H), 2.75-3.16 (m, 1H), 2.78 (m, 1H), 3.08 (t, J=8.6 Hz, 2H), 3.20-3.25 (m, 1H), 3.23-3.60 (m, 1H), 3.38-3.43 (m, 1H), 4.44 (t, J=8.9 Hz, 2H), 6.62 (d, J=8.1 Hz, 1H), 6.84 (d, J=8.1 Hz, 1H), 6.90 (d, J=6.9 Hz, 4H), 6.98 (s, 1H), 7.20-7.33 (m, 2H), 7.40 (d, J=6.6 Hz, 4H), 8.15 (brs, 1H); 13C NMR (75 MHz, CDCl3): delta 27.55, 29.06, 32.22, 40.06, 43.41, 50.94, 70.58, 108.36, 125.16, 126.33, 126.51, 126.96, 127.46, 127.69, 127.77, 128.55, 132.13, 141.18, 141.73, 157.81, 176.85; DIP MS: m/z (percent) 573 [M+H]+ (100). Anal. Calcd for C38H40N2O3: C, 79.69; H, 7.04; N, 4.89. Found: C, 79.48; H, 7.10; N, 4.79percent., 127264-14-6

The synthetic route of 127264-14-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Vasantha; Lakshmanarao; Srinivasa Rao; Sivalakshmi Devi; Venkata Suryanarayana; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 52; 6; (2013); p. 824 – 828;,
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New learning discoveries about 37418-88-5

37418-88-5 4-Hydroxyisobenzofuran-1,3-dione 96580, abenzofuran compound, is more and more widely used in various fields.

37418-88-5, 4-Hydroxyisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Decanoyl chloride (20 mul, ca. 0.1 mmol) in THF (2 ml) was cooled to 0 ¡ãC, and a solution of 1 (16.4 mg, 0.1 mmol) in THF (1.5 ml) was added dropwise; the mixture was stirred under 15 ¡ãC for 4 h. After this time, water was added and extracted with dichloromethane, then successively washed with H2O and brine. The organic layer was dried with MgSO4, and evaporated to give a crude product, which was chomatographed on silica gel eluting with CHCl3-MeOH to give 20 (70percent): white oil; 1H NMR (CDCl3, 400 MHz): delta 0.84 (t, J = 7.2 Hz, 3H), 1.23 (m, 12H), 1.72 (m, 2H), 2.24 (t, J = 6.4 Hz, 2H), 6.62 (d, J = 7.6 Hz, 1H), 6.64 (d, J = 8.0 Hz, 1H), 7.14 (t, J = 8.0 Hz, 1H); 13C NMR (CDCl3, 100 MHz): delta 172.3, 163.7, 163.5, 154, 143.1, 134.3, 130.1, 127.0, 126.7, 33.5, 31.9, 29.7, 29.4, 29.1, 25.1, 22.8, 14.1; HRFABMS m/z 319.1381 [M+H]+., 37418-88-5

37418-88-5 4-Hydroxyisobenzofuran-1,3-dione 96580, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Xiao, Bin; Yin, Jun; Park, Minhi; Liu, Juan; Li, Jian Lin; Kim, Eun La; Hong, Jongki; Chung, Hae Young; Jung, Jee H.; Bioorganic and Medicinal Chemistry; vol. 20; 16; (2012); p. 4954 – 4961;,
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