Day: October 27, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64169-34-2,5-Bromoisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

Step A: 5-(l,3-dioxolan-2-ylmethyl)-2-benzofuran-l(3H)-one A three-neck 5L round bottomed flask equipped with a stir bar, firestone valve, thermocouple, condenser and heating mantle was charged with tri-t-butyl phosphonium tetrafluoroborate (500 mg, 1.7 mmol), palladium (II) acetate (250 mg, 1.1 mmol) and 5-bromo-2-benzofuran-l(3H)-one (100 g, 470 mmol). DMF (1.9 L) was added to the flask, and the mixture was degassed three times by alternating vacuum and nitrogen purge. Commercially available bromo(l ,3-dioxolan- 2-ylmethyl)zinc solution (1.0 L, 520 mmol) was added via canula and the mixture was again degassed three times. The mixture was then heated at 85 C for 5 h. Analysis by HPLC-MS indicated the reaction was not complete. The mixture was stirred at 85 C for 5 more h. The mixture was then allowed to return to room temperature for overnight. 2-methyltetrahydrofuran (2.0 L) and brine were added, and the mixture was stirred for 5 min. The layers were separated and the aqueous layer was extracted again with 2-methyltetrahydrofuran. The organic layers were combined, washed three times with brine, dried over MgSC”4, filtered, and concentrated. The resulting residue was purified by flash chromatography (1.5 kg silica cartridge), eluting with 0->20% ethyl acetate in dichloromethane to afford 5-(l,3-dioxolan-2-ylmethyl)-2-benzofuran- l(3H)-one. MS: m/z 221 (M+l)+.

64169-34-2, As the paragraph descriping shows that 64169-34-2 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng; WO2013/39802; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13196-11-7,Benzofuran-6-ol,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of 6 (1 mmol) and potassium carbonate (3 mmol) in anhydrous DMF (5 ml) was added corresponding benzo cyclic phenol (1.1 mmol). After the resulting mixture was heated at 90-110 C for 3-10 h, the reaction was cooled to room temperature and poured into water (15 ml). The mixture was extracted with ethyl acetate for three times, and the organic layers were combined, washed with saturated brine (20 ml x 2), dried over anhydrous magnesium sulfate and evaporated under reduced pressure. The residue was purified by flash column chromatography to yield the desired compound.

13196-11-7, 13196-11-7 Benzofuran-6-ol 128844, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Zou, Qingan; Duan, Hongliang; Ning, Mengmeng; Liu, Jia; Feng, Ying; Zhang, Liming; Zhu, Junjie; Leng, Ying; Shen, Jianhua; European Journal of Medicinal Chemistry; vol. 82; (2014); p. 1 – 15;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.610-93-5,6-Nitroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

610-93-5, General procedure: The catalytic reduction of nitro aromatics was conducted in a 25 mlTelfon-lined stainless steel autoclave with magnetic stirring. In a typicalprocess, 6 mmol nitroarene, and desired amounts of reducing agent andsolvents were introduced in the reactor. The autoclave was transferredinto a water bath at the set temperature with an accuracy of better than0.2 C for ?0.5 h. Then, 10 mg catalyst was added into the reactionmixture and started the reduction at a stirring rate of 450 rpm. After thereaction, the catalyst was rapidly separated by ltration. n-Decane(500 muL) as standard was added into the ltrate and was dried withanhydrous Na 2 SO 4 . The products were analyzed by gas chromato-graphy-mass spectrometry (GC-MS) (Shimadzu GCMS-QP2010 Plus)and GC (Varian CP-3800) with a capillary column (column VF-1 ms,15 m, 0.25 mm, 0.25 mum) and a ame ionization detector (FID).

As the paragraph descriping shows that 610-93-5 is playing an increasingly important role.

Reference£º
Article; Huang, Haigen; Liang, Xiangcheng; Wang, Xueguang; Sheng, Yao; Chen, Chenju; Zou, Xiujing; Lu, Xionggang; Applied Catalysis A: General; vol. 559; (2018); p. 127 – 137;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42933-43-7,2,3-Dihydrobenzofuran-5-amine,as a common compound, the synthetic route is as follows.

2,3-dihydro-benzofuran-5-amine (1A) (5.7 g, 42.20 mmol) was added to hydrochloric acid (10.2 mL, 12N) water (25 mL) was cooled to -5 ¡ã C to 0 ¡ã C, solution of sodium nitrite (3.2 g, 46.4 mmol) in water (20 mL) solution, after the addition was complete, 0 ¡ã C for 30 minutes to obtain a diazonium salt solution, standby; then sodium acetate (7.9 g , 97.1 mmol) in water (25 ml) with 1-chloro-1- (methylsulfonyl) propyl-2-one (7.2g, 42.2 mmol) in ethyl acetate (70 mL) mixed solution, maintaining 0 ¡ã C, the diazonium salt solution was slowly alternate dropwise added to the mixture, after the addition was complete, the reaction at room temperature for 4 hours. The reaction solution was extracted stratification, the organic phase dried over anhydrous sodium sulfate, and concentrated under reduced pressure, the residue was purified by silica gel column chromatography (ethyl acetate / petroleum ether (v / v) = l: 4) to give the title compound Nu-(2,3-dihydrobenzofuran-5-yl)-1-methylsulfonylmethanehydrazonoyl chloride (12B) as a yellow solid (1.3 g, yield 11.2percent).

42933-43-7, The synthetic route of 42933-43-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SICHUAN HAISCO PHARMACEUTICAL CO LTD; WEI, YONGGANG; QIU, GUANPENG; LEI, BAILIN; LU, YONGHUA; (120 pag.)CN104395312; (2016); B;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

Advanced intermediate VII (4.3 g; 0.01 mol) is stirred up in an aqueous solution of potassium carbonate (6.1 g; 0.044 mol in 20 ml of water) at the laboratory temperature. A toluene solution (20 ml) of intermediate VIII (2.41 g; 0.011 mol) is added to the mixture and the mixture is heated in an oil bath T=90 ¡ãC while being stirred for 3.5 h. After cooling the toluene layer is separated and the aqueous layer is extracted with toluene. The combined toluene extracts are shaken with water and the solvent is distilled off at a reduced pressure. The evaporation residue is dissolved in ethylmethylketone, and an equimolar amount of 48percent hydrobromic acid is added. The separated darifenacine hydrobromide is filtered off and dried.Yield: 86percent of theory.

127264-14-6, 127264-14-6 5-(2-Bromoethyl)-2,3-dihydrobenzofuran 21831160, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; ZENTIVA, K.S.; WO2009/94957; (2009); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

271-89-6, Benzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of anisole 3A (3.0 mmol, 324.4 mg) in THF (3.0 mL) was added n-BuLi (4.5 mmol,1.55 M in hexane, 2.87 mL) at 0 C. The mixture was stirred for 2 h at 0 C under an argon atmosphere. Then, pivalonitrile (9.0 mmol, 748.2 mg) in THF (2.0 mL) was added to the mixture at 0 C and the obtained mixture was stirred for 30 min in the temperature range of 0 C to room temperature. MeOH (2.0 mL) was added to the mixture. Then, I2 (12.0 mmol, 3045.6 mg) and K2CO3 (12.0 mmol, 1658.4 mg) were added to the mixture at room temperature, and the obtained mixture was stirred for 6 h at 70 C. Sat. aq. Na2SO3 solution (20.0 mL) was added to the reaction mixture, and the product was extracted with AcOEt (10.0 mL x 3). The organic layer was dried over Na2SO4. After filtration and removal of the solvent, the residue was purified by silica-gel column chromatography (chloroform: n-hexane 1:1) to give 2-methoxybenzonitrile 2A (315.6 mg, 79%)., 271-89-6

The synthetic route of 271-89-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Uchida, Ko; Togo, Hideo; Tetrahedron; vol. 75; 39; (2019);,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

652-39-1, 4-Fluoroisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

652-39-1, A mixture of the above 4-fluoroisobenzofuran-1,3-dione (40 g, crude) and L-glutamine (35 g, 239 mmol) in dry DMF (200 mL) was stirred at 90 for 8 h. The solvent was removed under reduced pressure. The residue was re-dissolved in 4N HCl (200 mL) and stirred for additional 8 h. The resulting precipitation was collected by filtration, washed with water, and dried to afford 5-amino-2-(4-fluoro-1,3-dioxoisoindolin-2-yl)-5-oxopentanoic acid (37 g, crude) as an off-white solid. LC-MS: 295.2 [MH]+.1H NMR (400 MHz, CDCl3): delta 2.16-2.20 (m.2H), 2.31-2.43 (m, 2H), 4.79-4.83 (m, 1H), 6.79 (br, 1H), 7.26(br, 1H), 7.77-7.85 (m, 2H), 7.98-8.03 (m, 1H), 13.32(br, 1H).

The synthetic route of 652-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; YALE UNIVERSITY; CREWS, Craig M.; BURSLEM, George; CROMM, Philipp M.; JAIME-FIGUEROA, Saul; TOURE, Momar; (279 pag.)WO2019/148055; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

127264-14-6, 5-(2-Bromoethyl)-2,3-dihydrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 13Preparation of (R)-3-((bis(3-fluorophenyl)methoxy)carbonylamin l-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-l-azoniabicyclo[2.2.2]octane bromide (compound 32)To a solution of (R)-bis(3-fluorophenyl)methyl quinuclidin-3- ylcarbamate (53 mg, 0.14 mmol, prepared as in example 1) in ethyl acetate (2 ml), 5-(2-bromoethyl)-2,3-dihydrobenzofuran (32.3 mg, 0.14 mmol) was added. The resulting mixture was stirred at room temperature for 8 days and then the solvent was evaporated and the crude was purified by flash chromatography (DCM/MeOH=95/5) to collect (R)-3-((bis(3-fluorophenyl)- methoxy)carbonylamino)- l-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-l- azoniabicyclo[2.2.2]octane bromide (22.2 mg).1H NMR (300 MHz, DMSO-d6) delta ppm 8.08 (d, 1 H), 7.36 – 7.51 (m, 2H), 7.26 (d, 4 H), 7.06 – 7.19 (m, 3 H), 7.00 (d, 1 H), 6.64 – 6.81 (m, 2 H), 4.50 (t, 2 H), 3.92 – 4.13 (m, 1 H), 3.83 (t, 1 H), 3.37 – 3.59 (m, 4 H), 3.33 (d, 2 H), 3.19 – 3.25 (m, 1 H), 3.15 (t, 2 H), 2.90 (m, 2 H), 2.04 – 2.25 (m, 2 H), 1.68 – 2.04 (m, 3 H);LC-MS (ESI POS): 519.30 (M+)., 127264-14-6

As the paragraph descriping shows that 127264-14-6 is playing an increasingly important role.

Reference£º
Patent; CHIESI FARMACEUTICI S.p.A.; AMARI, Gabriele; RICCABONI, Mauro; DE ZANI, Daniele; WO2012/146515; (2012); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

64169-34-2, 5-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A three-neck 5L round bottomed flask equipped with a stir bar, firestone valve, thermocouple, condenser and heating mantle was charged with tri-t-butyl phosphonium tetrafluoroborate (500 mg, 1.72 mmol), palladium (II) acetate (250 mg, 1.1 mmol) and 5-bromo-2-benzofuran-l(3H)- one (100 g, 469 mmol). DMF (1.88 L) was added to the flask, and the mixture was degassed three times by alternating vacuum and nitrogen purge. Commercially available bromo(l ,3- dioxolan-2-ylmelhyl)zinc solution (1.033 L, 516 mmol) was added via canula and the mixture was again degassed three times. The mixture was then heated at 85 0C for 5 h. Analysis by HPLC-MS indicated the reaction was not complete. The mixture was stirred at 85 0C for 5 more h. The mixture was then allowed to return to room temperature for overnight. 2-methylTHF (2L) and brine were added, and the mixture was stirred for 5 min. The layers were separated and the aqueous layer was extracted again with 2-methylTHF. The organic layers were combined, washed three times with brine (4L each), dried over MgSO4, filtered, and concentrated. The crude product was purified by flash chromatography (1.5 kg silica cartridge), eluting with 0-20% ethyl acetate in dichlromethane to afford 5-(l;3-dioxolan-2-ylmethyl)-2-benzofuran-l(3/i)-one. MS: m/z 221 (M+l)+., 64169-34-2

As the paragraph descriping shows that 64169-34-2 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP &; DOHME CORP.; PASTERNAK, Alexander; SHAHRIPOUR, Aurash; TANG, Haifeng; TEUMELSAN, Nardos, H.; YANG, Lihu; ZHU, Yuping; WALSH, Shawn, P.; WO2010/129379; (2010); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

23681-89-2, 2,3-Dihydrobenzofuran-6-ol is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 5 0.87 g. of a 55percent by weight sodium hydride dispersion in oil are washed under nitrogen three times with absolute tetrahydrofuran and subsequently covered with 8 ml. of absolute tetrahydrofuran. Thereafter, the mixture is cooled to 0¡ã C. and treated dropwise while stirring with a solution of 2.72 g. of 6-hydroxy-2,3-dihydrobenzofuran in 12 ml. of absolute tetrahydrofuran. The mixture is stirred for 1.5 hours at room temperature and again cooled to 0¡ã C. before a solution of 4.0 g. of 1,3,5-trimethylhexyl p-toluenesulfonate in 10 ml. of absolute tetrahydrofuran is added. Subsequently, the mixture is diluted with 10 ml. of absolute hexamethylphosphoric acid triamide and stirred for 24 hours at room temperature. The mixture is poured onto ice-water and extracted three times with diethyl ether. The extracts are washed with water and saturated aqueous sodium chloride solution, dried over sodium sulfate and evaporated. By chromatography on silica gel with hexane/diethyl ether (98:2 parts by volume) there is obtained pure 6-[(1,3,5-trimethylhexyl)-oxy]-2,3 -dihydrobenzofuran which is distilled in a bulb-tube at 118¡ã C./0.3 mmHg; nD22 = 1.5057., 23681-89-2

As the paragraph descriping shows that 23681-89-2 is playing an increasingly important role.

Reference£º
Patent; Hoffmann-La Roche Inc.; US4002647; (1977); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem