Simple exploration of 115010-11-2

115010-11-2, 115010-11-2 2,3-Dihydro-1-benzofuran-5-sulfonoylchloride 2776154, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115010-11-2,2,3-Dihydro-1-benzofuran-5-sulfonoylchloride,as a common compound, the synthetic route is as follows.

Take compound IX-2 (300mg, 1.37mmol) in chlorobenzene (2mL),Add N-bromosuccinimide (244 mg, 1.37 mmol),Azobisisobutyronitrile (3mg),The temperature was raised to 80 C.After heating for 1.5 hours,Add N-bromosuccinimide (122 mg, 0.685 mmol),The reaction was monitored by TLC after 4 hours.After the reaction was cooled to room temperature, water (5 mL) was added.Ethyl acetate extraction (3mL x 3),Combined organic phases,Washed with saturated saline (3mL x 2),Dry over anhydrous sodium sulfate.The solvent was distilled off under reduced pressure,The residue was purified by column chromatography (petroleum ether / ethyl acetate = 50/1) to obtain compound XI-1 (yellow oil, 337 mg).

115010-11-2, 115010-11-2 2,3-Dihydro-1-benzofuran-5-sulfonoylchloride 2776154, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; China Pharmaceutical University; Sun Hongbin; Yan Dingfei; Feng Zhiqi; Zhang Jia; Yao Zhiying; Zhao Wenfeng; Zhang Xiangying; Sun Geng; Han Lishuai; Wu Wenzhen; Liu Shengjie; Zhao Xing; Li Minglei; Yu Shengqi; Chen Hui; Cheng Yalong; Wang Pengfei; Dai Liang; Wen Xiaoan; Liu Jun; (102 pag.)CN110372638; (2019); A;,
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Brief introduction of 69999-16-2

69999-16-2 2,3-Dihydrobenzofuranyl-5-acetic acid 2737455, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69999-16-2,2,3-Dihydrobenzofuranyl-5-acetic acid,as a common compound, the synthetic route is as follows.

69999-16-2, EXAMPLE 5 2-(2,3-Dihydro-5-benzofuranyl)malonic acid To a solution of diisopropylamide (20 mmole) in 50 ml of anhydrous tetrahydrofuran (THF) maintained under a nitrogen atmosphere at -40 C. is added n-butyllithium (20 mmole). The mixture is stirred for 15 minutes and then (2,3-dihydro-5-benzofuranyl)acetic acid (10 mmole) is added. The mixture is heated at 50 C. for 1 hour and then cooled to -70 C. and ethyl chloroformate (10 mmole) is added. The temperature is increased and the mixture is stirred for about 20 minutes. The mixture is poured over ice and hydrochloric acid. The aqueous phase is extracted with ether. The ether extracts are combined, dried and evaporated to give 2-(2,3-dihydro-5-benzofuranyl)malonic acid, monoethyl ester.

69999-16-2 2,3-Dihydrobenzofuranyl-5-acetic acid 2737455, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Richardson-Merrell Inc.; US4138397; (1979); A;,
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Analyzing the synthesis route of 641-70-3

641-70-3 3-Nitrophthalic anhydride 21631, abenzofuran compound, is more and more widely used in various fields.

641-70-3, 3-Nitrophthalic anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,641-70-3

Example 2A4-Nitroisobenzofuran- 1 (3H)-one[00471] A suspension of sodium borohydride (0.757 g, 20 mmol) in anhydrous tetrahydrofuran (120 mL) was cooled to 0 C. A solution of 4-nitrobenzofuran-l,3-dione (6.18 g, 32 mmol) in anhydrous tetrahydrofuran (30 mL) was then added dropwise to the suspension. After the addition, the mixture was allowed to stir at this temperature for 3 hr. The reaction was quenched with 3N hydrochloric acid (to pH=l). Water (40 mL) was added to the mixture and stirred for 1 hr. Tetrahydrofuran was removed under reduced pressure. The residue was partioned between water (150 mL) and ethyl acetate (150 mL*3). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, concentrated to give crude product. The crude product was purified by chromatography (silica gel, petroleum ether / ethyl acetate = 20: 1 to 2: 1) to give 4-nitroisobenzofuran- 1 (3H)-one (4.2 g, yield 73%) as a white solid. MS (ESI) m/z: 180(M+1)+. ^-NMR (400MHz, CDC13) delta 5.77 (s, 3H), 7.32-7.34 (d, J=8.4 Hz, 1H), 7.81-7.85 (t, J= 8.0 Hz, 1H), 8.29 (d, J= 8.0 Hz, 1H), 8.55 (d, J= 8.0 Hz, 1H).

641-70-3 3-Nitrophthalic anhydride 21631, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel; WO2011/130661; (2011); A1;,
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Some tips on 7168-85-6

As the paragraph descriping shows that 7168-85-6 is playing an increasingly important role.

7168-85-6, 7-Methoxybenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a round bottom flask containing 7-methoxybenzofuran (2.45 g, 16.5 mmol) and anhydrous DCM (25 mL) was carefully added a solution of boron tribromide in DCM (1 M, 33 mL) at 0 C. The reaction was allowed to warm to rt and stir at rt for 4 h. The reaction was quenched with water (20 mL), extracted with Et^O, concentrated to dryness, and purified by flash column chromatography to yield the title compound (1.23 g, 55% yield) as a light-brown oil. MS (ESI): mass calcd. for C8H602, 134.0.1; m/z found, 135.1 [M+H]+., 7168-85-6

As the paragraph descriping shows that 7168-85-6 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; ARORA, Nidhi; BACANI, Genesis M.; BARBAY, Joseph Kent; BEMBENEK, Scott D.; CAI, Min; CHEN, Wei; DECKHUT, Charlotte Pooley; EDWARDS, James P.; GHOSH, Brahmananda; HAO, Baoyu; KREUTTER, Kevin; LI, Gang; TICHENOR, Mark S.; VENABLE, Jennifer D.; WEI, Jianmei; WIENER, John J. M.; WU, Yao; ZHU, Yaoping; ZHANG, Feihuang; ZHANG, Zheng; XIAO, Kun; (1000 pag.)WO2017/100668; (2017); A1;,
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Some tips on 174775-48-5

As the paragraph descriping shows that 174775-48-5 is playing an increasingly important role.

174775-48-5, Ethyl 5-aminobenzofuran-2-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Commercially available ethyl 5-NITROBENZOFURAN-2-CARBOXYLATE 30 was HYDROGENATED on PD-C and ACYLATED using commercially available 4-NITRO-N-METHYL-2- TRICHLOROACETYL-PYRROLE 32 to form 33. HYDROGENATION of 33 followed by acylation with 32 afforded the nitro compound 35, which upon HYDROGENATION yielded 36 as the amino compound. ACETYLATION of the amino group of 36 followed by base catalyzed hydrolysis resulted in the acid 37. Coupling of 37 with the hydrochloride salt 39 (obtained by DEPROTECTION of the BOC derivative 38) using EDC afforded the ester 40. See Figure 4., 174775-48-5

As the paragraph descriping shows that 174775-48-5 is playing an increasingly important role.

Reference£º
Patent; THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; WO2005/32594; (2005); A2;,
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New learning discoveries about 59434-19-4

59434-19-4 4-Aminophthalide 12284649, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59434-19-4,4-Aminophthalide,as a common compound, the synthetic route is as follows.

59434-19-4, To a stirred mixture of 4-((diethylamino)methyl)benzaldehyde (3.7 g, 19.4 mmol) and anhydrous magnesium sulfate (11.6 g, 96.8 mmol) in anhydrous acetonitrile (100 mL) was added 4-aminoisobenzofuran-1(3H)-one (2.89 g, 19.4 mmol) at 0 C. After the addition the mixture was stirred refluxed for 3 days. The mixture was filtered and the cake was washed with ethyl acetate (50 mL¡Á3). The filtrate was concentrated to give crude product, which was re-crystallized from isopropanol to give the title compound (2.1 g, yield: 32%). LC-MS (ESI) m/z: 323 (M+1)+

59434-19-4 4-Aminophthalide 12284649, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; LEAD THERAPEUTICS, INC.; US2010/35883; (2010); A1;,
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Simple exploration of 17403-47-3

17403-47-3, The synthetic route of 17403-47-3 has been constantly updated, and we look forward to future research findings.

17403-47-3, 5-Nitro-2,3-dihydrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 21 (6.3 g, 38.1 mmol) and 10% palladium on carbon (1.0 g) in EtOH (50 mL) and THF (50 mL) was stirred under an atmosphere of H2 (1 atm) at room temperature for 13 h. The catalyst was removed by filtration, and then the filtrate was concentrated. The residue was purified by flash chromatography on SiO2 with a gradient eluent of 0-10% MeOH/EtOAc to provide 22 (4.63 g, 90%) as a pale brown powder; 1H NMR (CDCl3) delta: 3.12 (2H, t, J = 8.6 Hz), 3.37 (2H, s), 4.49 (2H, t, J = 8.6 Hz), 6.43-6.47 (1H, m) 6.57-6.61 (2H, m); Anal. Calcd for C8H9NO: C, 71.09; H, 6.71; N, 10.36. Found: C, 70.92; H, 6.60; N, 10.09.

17403-47-3, The synthetic route of 17403-47-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Shirai, Junya; Yoshikawa, Takeshi; Yamashita, Masayuki; Yamamoto, Yasuharu; Kawamoto, Makiko; Tarui, Naoki; Kamo, Izumi; Hashimoto, Tadatoshi; Ikeura, Yoshinori; Bioorganic and Medicinal Chemistry; vol. 19; 21; (2011); p. 6430 – 6446;,
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Brief introduction of 10242-11-2

The synthetic route of 10242-11-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-11-2,5-Bromobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: Shikonin (1mmol), benzofuran-2-carboxylic acid derivatives (4a-4q) (3mmol), 4-dimethyaminopyridine (0.5mmol), and N, N?- dicyclohexylcarbodiimide (0.5mmol) were suspended in the anhydrous DCM (10ml). The reaction mixture was stirred for 8h under 0C. Afterwards, the targeted compounds 6a-6q were purified by column chromatography., 10242-11-2

The synthetic route of 10242-11-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kong, Ling-Yi; Leng, Jia-Fu; Lian, Bao-Ping; Shao, Yu-Ying; Xia, Yuan-Zheng; Yin, Yong; European Journal of Medicinal Chemistry; vol. 190; (2020);,
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Downstream synthetic route of 1914-60-9

1914-60-9, The synthetic route of 1914-60-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1914-60-9,2,3-Dihydrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a mixture of 2,3-dihydrobenzofuran-2-carboxylic acid (1.0 g, 6.09 mmol) in DMF (10 mL) was added NCS (976 mg, 7.31 mmol) at 25 C, and the mixture was heated to 60 C for 3 h. The reaction mixture was adjusted to pH = 5-6 by addition of iN HC1, and EtOAc was added (10 mL). The layers were separated and the aqueous phase was extracted with EtOAc (3 x 5 mL). The combined organic phases were washed with brine (5 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to provide 5 -chloro-2,3 -dihydrobenzofuran-2-carboxylic acid.

1914-60-9, The synthetic route of 1914-60-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DENALI THERAPEUTICS INC.; CRAIG, Robert A., II; ESTRADA, Anthony A.; FENG, Jianwen A.; FOX, Brian; HALE, Christopher R. H.; LEXA, Katrina W.; OSIPOV, Maksim; REMARCHUCK, Travis; SWEENEY, Zachary K.; DE VICENTE FIDALGO, Javier; (187 pag.)WO2019/32743; (2019); A1;,
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New learning discoveries about 230642-84-9

230642-84-9, As the paragraph descriping shows that 230642-84-9 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.230642-84-9,4-Vinyl-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

To a solution of 4-ethenyl-2,3 – dihydro-1-benzofuran (5 g, 34.20 mmol, 1.00 equiv) in tetrahydrofuran (100 mL) and water (50 mL) was added 0504 (440 mg, 1.73 mmol, 0.05 equiv). The resulting solution was stirred for 30 mm at 20 C. Then Na104 (14.7 g, 68.69 mmol, 2.00 equiv) was added. The resulting solution was allowed to react, with stirring, for an additional 1 h at room temperature. The resulting solution was diluted with 100 mL of water. Then the resulting solution was extracted with ethyl acetate (2 x 50 mL) and the organic layers combined. The resulting mixture was washed with brine (2 x 50 mL), dried over anhydrous sodium sulfate and concentrated under vacuum to afford 5 g (99%) of 2,3-dihydro-1-benzofuran-4-carbaldehyde as light brown oil.

230642-84-9, As the paragraph descriping shows that 230642-84-9 is playing an increasingly important role.

Reference£º
Patent; AUSPEX PHARMACEUTICALS, INC.; ZHANG, Chengzhi; CHAKMA, Justin; LAUFER, Ralph; (108 pag.)WO2016/109359; (2016); A1;,
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