Tag: M.W=300-400

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Analysis of drug decomposition products. Part 32. Spectrophotometric method for evaluating the stability of phenylbutazone and aminophenazone in the preparation “”Rheumopyrin””.Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

Na phenylbutazone [129-18-0] and aminophenazone [58-15-1] were determined simultaneously by their resp. maximum absorption at 241 and 265 nm. Both the quant. spectrophotometric anal. and qual. anal. by thin-layer chromatog. on silica gel indicated the presence of decomposition products of phenylbutazone but not aminophenazone in the preparation Rheumopyrine [8066-94-2].

《Analysis of drug decomposition products. Part 32. Spectrophotometric method for evaluating the stability of phenylbutazone and aminophenazone in the preparation “”Rheumopyrin””》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Canipa, Steven J.; Stute, Annika; O’Brien, Peter researched the compound: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine( cas:767291-67-8 ).Synthetic Route of C20H42N2.They published the article 《Use of copper(II)/diamine catalysts in the desymmetrization of meso-diols and asymmetric Henry reactions: comparison of (-)-sparteine and (+)-sparteine surrogates》 about this compound( cas:767291-67-8 ) in Tetrahedron. Keywords: acylation benzoylation Henry reaction catalyst copper diamine sparteine. We’ll tell you more about this compound (cas:767291-67-8).

Four new copper(II)/diamine complexes comprising some (+)-sparteine surrogates and a cyclohexane-derived diamine were prepared and evaluated as chiral catalysts in desymmetrization of meso-diols and an asym. Henry reaction. A mono-benzoylation reaction generated two products with high enantioselectivity (90:10 to 97:3 er). An asym. Henry reaction gave nitro alcs. in 90:10 to 98:2 enantiomeric ratio (er). Notably, the sense of induction with the (+)-sparteine surrogates was opposite to that obtained using the copper(II)/(-)-sparteine complex. One of the nitro alc. products was used in a concise synthesis of a chiral morpholine derivative, (2S)-2-phenylmorpholine. Under optimized conditions the synthesis of the target compounds was achieved using (1R,2S)-rel-1,2-diphenyl-1,2-ethanediol and benzoyl chloride as starting materials and (7S,7aR,14S,14aS)-dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1′,2′-e][1,5]diazocine-copper complex [(-)-sparteine-copper complex] as catalyst. The title compound thus formed was (1S,2R)-1,2-diphenyl-1,2-ethanediol 1-benzoate. Using a sparteine surrogate, such as (+)-(1R,5S,11aS)-Decahydro-3-methyl-1,5-methano-2H-pyrido[1,2-a][1,5]diazocine-copper complex gave (1R,2S)-1,2-diphenyl-1,2-ethanediol 1-benzoate.

Different reactions of this compound((1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine)Synthetic Route of C20H42N2 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Study of pharmaceutical availability of phenylbutazone and its sodium salt from selected suppository bases., the main research direction is phenylbutazone sodium release suppository.SDS of cas: 129-18-0.

Phenylbutazone Na [129-18-0] was released 2-10 times more rapidly than phenylbutazone [50-33-9] from suppositories, the exact ratio depending on the base. The former was also more stable in suppository formulations. The most rapid release was obtained from cocoa butter and Witepsol H 15.

《Study of pharmaceutical availability of phenylbutazone and its sodium salt from selected suppository bases.》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)SDS of cas: 129-18-0.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fitzgerald, T. J.; Williams, Betsy; Uyeki, E. M. published the article 《Antimitotic and anti-inflammatory agents on sodium urate-induced paw swelling in mice》. Keywords: antimitotic paw swelling; antiinflammatory agent edema; colchicine antimitotic.They researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).COA of Formula: C19H19N2NaO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:129-18-0) here.

The antimitotics colchicine (I) [64-86-8] (2 mg/kg), vinblastin [865-21-4] (8 mg/kg), vincristine [57-22-7] (1 mg/kg), and podophyllotoxin [518-28-5] (2 or 10 mg/kg) produced in mice a significant suppression of paw swelling at similar dose levels. Deacetamidocolchicine [1420-08-2], a more potent antimitotic agent than I, was less active against paw swelling even when given in a 58-fold greater dose. The antiinflammatory agents prednisone [53-03-2] (12 mg/kg) and indomethacin [53-86-1] (20 mg/kg) inhibited paw swelling but phenylbutazone [50-33-9] (250 mg/kg), even at lethal doses, was inactive in this respect.

《Antimitotic and anti-inflammatory agents on sodium urate-induced paw swelling in mice》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)COA of Formula: C19H19N2NaO2.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application of 129-18-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Age-dependence of succinate dehydrogenase (SDH) in rat liver and its inducibility after barbital and phenylbutazone pretreatment. Author is Barth, A.; Klinger, W..

The succinate dehydrogenase [9002-02-2] activity of rat liver homogenates increased 3-fold from 1 day before to 1 day after birth. Treatment for 3 days with barbital Na (I) [144-02-5] (150 mg/kg, i.p.) or phenylbutazone Na (II Na) [129-18-0] (50 or 100 mg/kg, i.p.) had no effect on the enzyme activity of rats aged 8, 30, 60, or 240 days.

《Age-dependence of succinate dehydrogenase (SDH) in rat liver and its inducibility after barbital and phenylbutazone pretreatment》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)Application of 129-18-0.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Von Bruchhausen, V.; Lohmann, H.; Osvath, J. published the article 《The pharmacokinetic profile of pyrazinobutazone in man》. Keywords: pyrazinobutazone formulation pharmacokinetics.They researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).SDS of cas: 129-18-0. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:129-18-0) here.

The rate of absorption of phenylbutazone (I) [50-33-9] from pyrazinobutazone [4985-25-5] capsules was lower than that from I capsules. The capsules were bioequivalent to an equimolar dose of Na phenylbutazone [129-18-0] in solution, as judged by both the area under the plasma level curves and the sum of the unchanged I excreted in the urine. A single dose of 300 mg pyrazinobutazone produced maximum plasma levels of 35.2 μg/mL at 5.5 h after administration. Two dosage schedules for long-term therapy were tested (2400 and 1500 mg/wk). Both produced accumulation to saturation plasma levels within approx. 3 days. The concentration of I obtained with the lower dosage was about 110 μg/mL plasma. This corresponded with the recommendations for long-term therapy with I. With the higher dosage, the plasma levels were elevated by only 25%, however, the renal elimination of unchanged drug and the number of side-effects were remarkably increased. The recommended dosage scheme is specifically adapted to the pharmacokinetics of pyrazinobutazone.

Different reactions of this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)SDS of cas: 129-18-0 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Veterinary Pharmacology and Therapeutics called Residue profile of phenylbutazone in the rabbit. A comparative evaluation by tissue kinetics prior to and post-mortem, Author is Toutain, P. L.; Alvinerie, M.; Ruckebusch, Y., which mentions a compound: 129-18-0, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2, COA of Formula: C19H19N2NaO2.

The disposition kinetics and residue levels of Na phenylbutazone (8 mg/kg) were studied in rabbits as a model for cattle. The results suggest that distribution of phenylbutazone can be described by a 2 compartment open model. The elimination half-time is short (2 h), and the estimation of residue levels in muscle, liver, and kidney did not differ significantly before and after bleeding. Apparently, biopsy tissue can be used to determine the tissue phenylbutazone concentration of larger species. Moreover, by using a pharmacokinetic approach based on drug concentrations in plasma, it appeared that the mean resting quantity in the peripheral compartment was very close to the exptl. data for the muscle.

The article 《Residue profile of phenylbutazone in the rabbit. A comparative evaluation by tissue kinetics prior to and post-mortem》 also mentions many details about this compound(129-18-0)COA of Formula: C19H19N2NaO2, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Di Perri, T.; Auteri, A. published an article about the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+] ).Product Details of 129-18-0. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:129-18-0) through the article.

Lysine acetylsalicylate (I) [37933-78-1], flufenamic acid [530-78-9], mefenamic acid [61-68-7], indomethacin [53-86-1], and Na phenylbutazone [129-18-0] had anticomplementary activity in vitro. I inhibited the activation of C1, whereas flufenamic and mefenamic acids inhibited the activation of C3. Indomethacin inhibited C2, C3, and C4, while phenylbutazone inhibited C3 and C4. These drugs were also anticomplementary in vivo.

The article 《Anticomplementary action of some nonsteroidal antiinflammatory drugs》 also mentions many details about this compound(129-18-0)Product Details of 129-18-0, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Computed Properties of C19H19N2NaO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Synthesis of certain new 3,5-dioxopyrazolidines of pharmacological interest. Author is Abou-Gharbia, M.; El Zanfally, S.; Khalifa, M..

Pyrazolidinediones I [R = R1 = 5-nitro-2-pyridyl (Q), R2 = R3 = Et, Pr, Bu; R = Q, Ph, R1 = Ph, R2 = Q, R3 = Bu; R = Q, R1 = Ph, R2 = R3 = Et] were obtained in 60-73% yield by treating Na derivatives of appropriately substituted pyrazolidinediones with QCl.

The article 《Synthesis of certain new 3,5-dioxopyrazolidines of pharmacological interest》 also mentions many details about this compound(129-18-0)Computed Properties of C19H19N2NaO2, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Pharmacology of antiinflammatory imidazoles. Author is Winter, R..

Of 67 imidazole derivatives tested for antinflammatory activity in rats, 2,5-dimethyl-4-phenylimidazole-HCl (I) [40405-82-1] was the most active. Its antiedema and granulation inhibiting actions were greater than those of phenylbutazone sodium [129-18-0]. On further testing I potentiated hexobarbital narcosis in mice, had anticonvulsive activity in mice, and decreased the body temperature of rats. It did not have a central analgetic effect. The acute LD50 values for I were 71 mg/kg i.p. and 230 mg/kg orally in mice and 76.5 mg/kg s.c. in rats.

The article 《Pharmacology of antiinflammatory imidazoles》 also mentions many details about this compound(129-18-0)Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem