Tag: 164.158

Ultraviolet spectra and methoxy and methylenedioxy groups of some aromatic compounds and alkaloids. X. Electronic spectra of 1-tetralone, homophthalide, 3,4-dihydroisoquinoline, and 3,4-dihydroisoquinolinium compounds was written by Santavy, Frantisek;Valka, Ivo. And the article was included in Collection of Czechoslovak Chemical Communications in 1980.Reference of 4741-62-2 This article mentions the following:

The UV of the title compounds substituted by electron donating groups (OH, MeO, o-OCH₂O) on the aromatic nucleus, are similar when the electron donors were at the same distance from the electron accepting substituent. The increase in the ring size from 1-indanone to 1-tetralone, or from phthalide to homophthalide had no significant effect on the position and the intensity of the A and the B bands. The changes of the UV of 3,4-dihydroisoquinolinium compounds in alk.-EtOH media is discussed. In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2Reference of 4741-62-2).

5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Reference of 4741-62-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ultraviolet spectra, methoxy, and methylenedioxy groups of some aromatic compounds and alkaloids. II. The effect of methoxy and methylenedioxy groups on the ultraviolet spectra of aromatic compounds with a conjugated carbonyl chromophore was written by Santavy, Frantisek;Hruban, Ladislav;Simanek, Vaclav;Walterova, D.. And the article was included in Collection of Czechoslovak Chemical Communications in 1970.Name: 5-Methoxyisobenzofuran-1(3H)-one This article mentions the following:

Characteristic changes in the location and intensity of absorption bands in the uv region are given and discussed with regard to the nature and position of the electron donating O-containing substituents in numerous derivatives of benzene, indanones, protoochotensimine compounds, phthalic acids, protopine and oxyprotopine alkaloids. In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2Name: 5-Methoxyisobenzofuran-1(3H)-one).

5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Name: 5-Methoxyisobenzofuran-1(3H)-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Activation energy and frequency factor in the alkaline hydrolysis of phthalides was written by Vene, Jean;Tirouflet, Jean;Carrie, Robert. And the article was included in Compt. rend. in 1952.Application In Synthesis of 5-Methoxyisobenzofuran-1(3H)-one This article mentions the following:

The alk. (0.002 M) hydrolysis is studied at 15°, 25°, 35°, and 45° in 20% EtOH (by weight) of phthalides (0.002 M) mono-substituted in the benzene nucleus in the 4, 5, 6, or 7 position by the groups: NH₂, OCH₃, Cl, and Br. For each of the derivatives in the 5, 6, and 7 positions and for the 4-methoxy-phthalide the factors PZ and E of the Arrhenius equation, k = PZ e^-E/RT, remain constant within the limit of exptl. error. The ortho effect of substituents halogenated in the 7 position, responsible for the low value of the factor PZ in the case of o-halobenzoic esters, is considerably lessened for the phthalides. In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2Application In Synthesis of 5-Methoxyisobenzofuran-1(3H)-one).

5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Application In Synthesis of 5-Methoxyisobenzofuran-1(3H)-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Visible Light-Promoted Magnesium, Iron, and Nickel Catalysis Enabling C(sp³)-H Lactonization of 2-Alkylbenzoic Acids was written by Li, Sasa;Su, Mincong;Sun, Jie;Hu, Kunjun;Jin, Jian. And the article was included in Organic Letters in 2021.Formula: C9H8O3 This article mentions the following:

A mild and practical C(sp³)-H lactonization protocol has been achieved by merging photocatalysis and magnesium (iron, nickel) catalysis. A diverse range of 2-alkylbenzoic acids with a variety of substitution patterns could be transformed into the corresponding phthalide products. Based on the mechanistic experimentation and reported prior studies, a possible mechanism for the benzylic oxidative lactonization reaction was proposed with the hypothetic photoactive ternary complex formed between the 2-alkylbenzoic acid substrate, magnesium ion, and bromate anion. In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2Formula: C9H8O3).

5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Formula: C9H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Manganese- and Borane-Mediated Synthesis of Isobenzofuranones from Aromatic Esters and Oxiranes via C-H Bond Activation was written by Sueki, Shunsuke;Wang, Zijia;Kuninobu, Yoichiro. And the article was included in Organic Letters in 2016.Name: 5-Methoxyisobenzofuran-1(3H)-one This article mentions the following:

A manganese- and borane-mediated synthesis of isobenzofuranones from esters and oxiranes is developed. The reaction proceeded at aromatic, heteroaromatic, and olefinic C-H bonds with high functional group tolerance. This is the first example of a manganese-catalyzed C-H transformation using an oxygen-directing group. Triphenylborane played an important role in this reaction to cooperatively promote the annulation reaction. Kinetic isotope effect experiments revealed that C-H bond activation of the aromatic rings was the rate-determining step. In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2Name: 5-Methoxyisobenzofuran-1(3H)-one).

5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Name: 5-Methoxyisobenzofuran-1(3H)-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chiral Bicyclic Imidazole-Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters was written by Zhou, Muxing;Gridneva, Tatiana;Zhang, Zhenfeng;He, Ende;Liu, Yangang;Zhang, Wanbin. And the article was included in Angewandte Chemie, International Edition in 2021.Electric Literature of C9H8O3 This article mentions the following:

Utilizing a chiral bicyclic imidazole organocatalyst, I, and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3-hydroxyphthalides through enantioselective acylation (up to 99% ee). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure anal. of the key transition states shows that the CH-π interaction, and not the previously considered cation/π-π interactions between the catalyst and substrate, is the dominant factor giving rise to the observed stereocontrol. In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2Electric Literature of C9H8O3).

5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Electric Literature of C9H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chiral Bicyclic Imidazole-Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters was written by Zhou, Muxing;Gridneva, Tatiana;Zhang, Zhenfeng;He, Ende;Liu, Yangang;Zhang, Wanbin. And the article was included in Angewandte Chemie, International Edition in 2021.Electric Literature of C9H8O3 This article mentions the following:

Utilizing a chiral bicyclic imidazole organocatalyst, I, and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3-hydroxyphthalides through enantioselective acylation (up to 99% ee). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure anal. of the key transition states shows that the CH-π interaction, and not the previously considered cation/π-π interactions between the catalyst and substrate, is the dominant factor giving rise to the observed stereocontrol. In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2Electric Literature of C9H8O3).

5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Electric Literature of C9H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem