Vene, Jean et al. published their research in Compt. rend. in 1952 | CAS: 4741-62-2

5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Application In Synthesis of 5-Methoxyisobenzofuran-1(3H)-one

Activation energy and frequency factor in the alkaline hydrolysis of phthalides was written by Vene, Jean;Tirouflet, Jean;Carrie, Robert. And the article was included in Compt. rend. in 1952.Application In Synthesis of 5-Methoxyisobenzofuran-1(3H)-one This article mentions the following:

The alk. (0.002 M) hydrolysis is studied at 15°, 25°, 35°, and 45° in 20% EtOH (by weight) of phthalides (0.002 M) mono-substituted in the benzene nucleus in the 4, 5, 6, or 7 position by the groups: NH2, OCH3, Cl, and Br. For each of the derivatives in the 5, 6, and 7 positions and for the 4-methoxy-phthalide the factors PZ and E of the Arrhenius equation, k = PZ e-E/RT, remain constant within the limit of exptl. error. The ortho effect of substituents halogenated in the 7 position, responsible for the low value of the factor PZ in the case of o-halobenzoic esters, is considerably lessened for the phthalides. In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2Application In Synthesis of 5-Methoxyisobenzofuran-1(3H)-one).

5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Application In Synthesis of 5-Methoxyisobenzofuran-1(3H)-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem