Tag: 100-200

Synthesis and recognition properties of tweezer-shaped anion receptors based on acylhydrazone units was written by Zou, Linbo;Pan, Dingwu;Yan, Bairen;Tan, Zan;Lu, Xinyang;Du, Huan;Bao, Xiaoping. And the article was included in Huaxue Tongbao in 2015.Application of 1646-27-1 This article mentions the following:

An indole-acylhydrazone-based tweezer-shaped anion receptor (I) was designed and synthesized, and it displayed a selective recognition for biol. important F^–, AcO^– and H₂PO₄^– (K_a > 10⁴ L/mol with a 1:1 stoichiometry) in CH₃CN containing 1 (vol)% DMSO. However, no binding interaction was observed for other anions such as Cl^–, Br^–, I^–, NO₃^–, N₃^–, HSO₄^– and ClO₄^–. Compared with 1, reference compound 2 (end groups were benzofuran) showed a decreased affinity towards the above three anions, especially for H₂PO₄^–. ¹H NMR titration experiments indicated that cooperative utilization of indole NHs and amide NHs within 1 led to it strong binding with anions. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Application of 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application of 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis of some biologically active 2&2,2-disubstituted 1,2,3,4-tetrahydro-4-thiobenzofuro[3,2-d]pyrimidines and their reactions was written by Basavaraja, K. M.;Patil, V. M.;Agasimundin, Y. S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2007.SDS of cas: 54802-10-7 This article mentions the following:

The condensation of 3-amino-2-carboxamide (I) with various aldehydes in the presence of hydrochloric acid gave the corresponding 2-aryl-1,2,3,4-tetrahydro-4-oxobenzofuro[3,2-d]pyrimidines II (X = O; R¹ = H; R² = Ph, 4-NO₂C₆H₄, 4-MeOC₆H₄, furyl). Compound I was converted into the required intermediate thiocarboxamide by the reaction with phosphorus pentasulfide in anhyd pyridine. The acid-catalyzed condensation of the thiocarboxamide with various ketones afforded the anticipated 2,2-dialkyl-1,2,3,4-tetrahydro-4-thiobenzofuro[3,2-d]pyrimidines II (X = S; R¹ = R² = Me; R¹ = Me, R² = Et; R¹ = R² = Et; R¹ = Me, R² = iBu), and with various aromatic aldehydes under similar conditions furnished the resp. 2-aryl-1,2,3,4-tetrahydro-4-thiobenzofuro[3,2-d]pyrimidines II (X = S; R¹ = H; R² = Ph, 4-NO₂C₆H₄, 4-MeOC₆H₄, furyl) in good yields. The methylation of the tetrahydrothiobenzofuro[3,2-d]pyrimidines led to the formation of a product which was found to be identical with 3-aminobenzofuran-2-carbonitrile, which has already been prepared in this laboratory Compounds II (X = S; R¹ = R² = Me; R¹ = Me, R² = Et; R¹ = R² = Et; R¹ = Me, R² = iBu; R¹ = H, R² = 4-OMeC₆H₄) underwent displacement by morpholine or piperidine to produce the resp. derivatives III (X = CH₂ or O). The synthesis of 1,2,3,4-tetrahydro-2-oxo-4-thiobenzofuro[3,2-d]pyrimidine (IV) and displacement of the mercapto group to produce the corresponding cyclic amine-substituted compounds was also investigated. The structures of all the compounds were well supported by spectral and anal. data. Some of the compounds exhibited moderate to appreciable antibacterial activity against S. aureus and E. coli. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7SDS of cas: 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.SDS of cas: 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and biological activities of pyrazolinobenzofuro[3,2-d]pyridimidines was written by Basawaraj, Raga;Goled, S. N.;Khandre, Omakar;Sangapure, S. S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2011.Name: 3-Aminobenzofuran-2-carboxamide This article mentions the following:

2-(2,4,6-Trimethoxyphenyl/α-naphthyl)-4-hydrazinobenzofuro[3,2-d]pyrimidines 5,6 were prepared by nucleophilic substitution of 2-(trimethoxyphenyl/α-naphthyl)-4-chlorobenzofuro[3,2-d]pyrimidines 3,4 with N₂H₄.H₂O in MeOH. The reaction of 2-substituted 4-hydrazinobenzofuro[3,2-d]pyrimidines 5,6 with Ac₂CH₂, NCCH₂CO₂Et, or AcCH₂CO₂Et in NaOEt furnished pyrazolyl- and pyrazolinylbenzofuro[3,2-d]pyrimidines. These compounds exhibited antimicrobial and anti-inflammatory activity. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Name: 3-Aminobenzofuran-2-carboxamide).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Name: 3-Aminobenzofuran-2-carboxamide

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Enantioselective Intermolecular Mannich-Type Interception of Phenolic Oxonium Ylide for the Direct Assembly of Chiral 2,2-Disubstituted Dihydrobenzofurans was written by Hong, Kemiao;Dong, Shanliang;Xu, Xinxin;Zhang, Zhijing;Shi, Taoda;Yuan, Haoxuan;Xu, Xinfang;Hu, Wenhao. And the article was included in ACS Catalysis in 2021.Formula: C10H8O3 This article mentions the following:

An enantioselective intermol. Mannich-type interception of phenolic oxonium ylides with imines has been developed. The cooperative catalysis with achiral dirhodium complex and chiral phosphoric acid has been introduced to circumvent the competitive phenolic O-H bond insertion via dual H-bonding, enabling the synthesis of enantioenriched 2,2-disubstituted dihydrobenzofurans with good to high yield and high to excellent enantioselectivity under mild conditions. Preliminary antitumor activity study of these generated products indicated that the reduction product I exhibits high anticancer potency against human lung adenocarcinoma cells (A549 cells, IC₅₀ = 9.13μM). In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Formula: C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Formula: C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Photochemical codimerization of benzofurans was written by Takamatsu, Kuniaki;Ryang, Hong-Son;Sakurai, Hiroshi. And the article was included in Journal of Organic Chemistry in 1976.Recommanded Product: Methyl benzofuran-2-carboxylate This article mentions the following:

The photochem. codimerization of benzofuran with 2-substituted benzofurans has been examined. Irradiation of benzofuran with 2-(3-pyridyl)benzofuran or 2-phenylbenzofuran gave the head-to-tail syn- (I, R = 3-pyridyl or Ph) and anti-cyclobutane codimers (I, α-H) as main products. Benzofuran with Me benzofuran-2-carboxylate on irradiation gave the head-to-head syn codimer II in addition to one homodimer of Me benzofuran-2-carboxylate and two carbonyl compounds III and IV. The former proceeds via the excited singlet of benzofuran and the latter involves the excited singlet of Me benzofuran-2-carboxylate. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Recommanded Product: Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Recommanded Product: Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis of aryloxy analogs of arachidonic acid via Wittig and palladium-catalyzed cross-coupling reactions was written by Buckle, Derek R.;Fenwick, Ashley E.;Outred, D. James;Rockell, Caroline J. M.. And the article was included in Journal of Chemical Research, Synopses in 1987.Recommanded Product: Methyl benzofuran-2-carboxylate This article mentions the following:

2- And 4-HO₂C(CH₂)_nOC₆H₄CH:CH(CH₂)₆R (I, R = H, Pr, Bu, pentyl; n = 1-3) were prepared by Wittig olefination of HOC₆H₄CHO and HO₂C(CH₂)_nOC₆H₄CHO, but the E–Z isomer ratio was difficult to control. Z–I were obtained by partial reduction of R¹O₂C(CH₂)_nOC₆H₄CC(CH₂)₆R (R¹ = Me, Et), prepared by reaction of Me₃CSiMe₂OC₆H₄Br with HCC(CH₂)₆R. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Recommanded Product: Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Recommanded Product: Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis of fused furans by gas-phase pyrolysis of 2-allyloxyaryl-propenoic esters was written by Black, Michael;Cadogan, J. I. G.;Mcnab, Hamish;Macpherson, Andrew D.;Roddam, V. Peter;Smith, Carol;Swenson, Helen R.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry in 1997.Recommanded Product: Methyl benzofuran-2-carboxylate This article mentions the following:

Flash vacuum pyrolysis of 2-allyloxypropenoic esters, e.g., I, gives benzo[b]furans, e.g., II, in synthetically useful yields by sequential generation of a phenoxyl radical, cyclization and ejection of the carboxylic ester function as a free radical leaving group. The method is compatible with a range of substituents on either the benzene ring or the propenoate chain, and is particularly effective for 2-substituted benzo[b]furans. The natural products 5-methoxybenzo[b]furan and angelicin have been synthesized in three and four steps resp. from com. available starting materials by this route. Related cyclizations to give naphtho[2,1-b]furan III were complicated by competitive formation of naphtho-[2,1b]pyran-3-ones, but the yield of the required product could be optimized by the choice of the radical precursor. Annulation of a furan ring onto a thiophene is also possible by this method, but lower yields are obtained in such pyrolyzes. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Recommanded Product: Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Recommanded Product: Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and biological evaluation of benzofuro[3,2-d]pyrimidines was written by Basawaraj, Raga;Shashikanth, Goled;Hugar, M. H.;Sangapure, S. S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2009.Related Products of 54802-10-7 This article mentions the following:

The reaction of 3-amino-2-benzofurancarboxamide with 3,4,5-trimethoxybenzaldehyde in presence of catalytic quantity of conc hydrochloric acid gave 2-aryl-3,4-dihydro-4-oxo-benzofuran[3,2-d]pyrimidine (I). The nucleophilic displacement reaction of the compound I with phosphorus oxychloride furnished 2-(3,4,5-trimethoxyphenyl)-3,4-dihydro-4-chlorobenzofuro[3,2-d]pyrimidine (II). Some 2,4-disubstituted benzofuran[3,2-d]pyrimidine derivatives were prepared by the reaction of compound II with different reagents. All the synthesized compounds were characterized on the basis of IR, ¹H NMR, mass spectra and anal. data. The compounds synthesized were screened for antibacterial and antifungal activities. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Related Products of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Related Products of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Detection of Zinc(II) by a Fluorescence Chemosensor Based on Benzofuran in Aqueous Media and Live Cells was written by Jang, Hyo Jung;Kim, Ahran;Jung, Jae Min;Lee, Misun;Lim, Mi Hee;Kim, Cheal. And the article was included in Bulletin of the Korean Chemical Society in 2018.Related Products of 54802-10-7 This article mentions the following:

A fluorescence chemosensor HBC ((E)-3-((2-hydroxybenzylidene)amino)benzofuran-2-carboxamide) for detection of Zn²⁺ was designed by the condensation combination of 3-aminobenzofuran-2-carboxamide and salicylaldehyde. Sensor HBC showed an excellent selective “off-on” fluorescent response toward Zn²⁺. Detection limit (1.08μM) for Zn²⁺ was much lower than the WHO standard (76.0μM). Importantly, HBC could recognize and quantify Zn²⁺ in real samples and live cells. Detection process of HBC for Zn²⁺ was explained by ESI-mass, Job plot, UV-Vis and ¹H NMR titrations, and theor. calculations In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Related Products of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Related Products of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Direct Carboxylation of Electron-Rich Heteroarenes Promoted by LiO-tBu with CsF and [18]Crown-6 was written by Shigeno, Masanori;Hanasaka, Kazuya;Sasaki, Keita;Nozawa-Kumada, Kanako;Kondo, Yoshinori. And the article was included in Chemistry – A European Journal in 2019.Safety of Methyl benzofuran-2-carboxylate This article mentions the following:

The combination of LiO-tBu, CsF, and [18]crown-6 efficiently promoting the direct C-H carboxylation of electron-rich heteroarenes (benzothiophene, thiophene, benzofuran, and furan derivatives) I (R = Me, CN, Br, MeO, Cl, F; R¹ = H, CH₃, Br) and II (R² = Br, C₆H₅, C(O)C₆H₅, etc.; R³ = H; R²R³ = CH=CH-CH=CH; X = O, S) has been demonstrated. A variety of functional groups, including Me, methoxy, halo, cyano, amide, and keto moieties, is compatible with this system. The reaction proceeds via the formation of a tert-Bu carbonate species. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Safety of Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Safety of Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem