Enantioselective Intermolecular Mannich-Type Interception of Phenolic Oxonium Ylide for the Direct Assembly of Chiral 2,2-Disubstituted Dihydrobenzofurans was written by Hong, Kemiao;Dong, Shanliang;Xu, Xinxin;Zhang, Zhijing;Shi, Taoda;Yuan, Haoxuan;Xu, Xinfang;Hu, Wenhao. And the article was included in ACS Catalysis in 2021.Formula: C10H8O3 This article mentions the following:
An enantioselective intermol. Mannich-type interception of phenolic oxonium ylides with imines has been developed. The cooperative catalysis with achiral dirhodium complex and chiral phosphoric acid has been introduced to circumvent the competitive phenolic O-H bond insertion via dual H-bonding, enabling the synthesis of enantioenriched 2,2-disubstituted dihydrobenzofurans with good to high yield and high to excellent enantioselectivity under mild conditions. Preliminary antitumor activity study of these generated products indicated that the reduction product I exhibits high anticancer potency against human lung adenocarcinoma cells (A549 cells, IC50 = 9.13μM). In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Formula: C10H8O3).
Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Formula: C10H8O3
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem