Extended knowledge of N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide

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Related Products of 6296-53-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4. In a article,once mentioned of 6296-53-3

Methods of treating cutaneous lupus in a human are disclosed. Specific methods encompass the administration of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione (ACTIMID), 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione (REVLIMID), or cyclopropyl 2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindolin-4-yl}carboxamide, alone or alternatively, in combination with a second active agent.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3477O – PubChem

More research is needed about Tetrafluorophthalic anhydride

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A novel heteroacene, 2-(2,3,4,5-tetrafluorophenyl)-1H-imidazo[4,5-b] phenazine has been successfully synthesized. The heteroacene can selectively detect F- over Cl-, Br-, I-, NO 3-, HSO4-, ClO4 -, and BF4- in organic solvents through colorimetric and fluorescent responses. The interaction between the heteroacene and F- was investigated through UV-Vis, fluorescence, and 1H NMR titration experiments, which suggested that the effects might occur via a combined process including hydrogen bond, deprotonation, and anion-pi interactions between the sensor and F-.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3777O – PubChem

Extracurricular laboratory:new discovery of 4-Bromo-2-benzofuran-1[3H]-one

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The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula (I); where A1, A2, G, R1, R2, R3, R4, and W are described herein.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3580O – PubChem

Extracurricular laboratory:new discovery of 2,3-Dihydrobenzofuran-5-amine

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The systematic shortening of the noncovalent element of a C8-linked pyrrolobenzodiazepine (PBD) conjugate (13) led to the synthesis of a 19-member library of C8-PBD monomers. The critical elements of 13, which were required to render the molecule cytotoxic, were elucidated by an annexin V assay. The effects of shortening the noncovalent element of the molecule on transcription factor inhibitory capacity were also explored through an enzyme-linked immunosorbent assay-based measurement of nuclear NF-kappaB upon exposure of JJN-3 cells to the synthesized molecules. Although shortening the noncovalent interactive element of 13 had a less than expected effect upon compound cytotoxicity due to reduced DNA interaction, the transcription factor inhibitory capacity of the molecule was notably altered. This study suggests that a relatively short noncovalent side chain at the C8 position of PBD is sufficient to confer cytotoxicity. The shortened PBD monomers provide a new ADC payload scaffold because of their potent cytotoxicity and drug-like properties.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H501O – PubChem

Some scientific research about Benzofuran-2-carboxylic acid

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. HPLC of Formula: C9H6O3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 496-41-3, name is Benzofuran-2-carboxylic acid. In an article,Which mentioned a new discovery about 496-41-3

The potential of TBHP to promote oxidative hydroxylation of alpha-hydroxy-beta-oxophosphonates (HOPs) through C(CO)-C bond cleavage is described. This cleavage, as depicted in the mechanism is expected through an isomer of HOP that reacts with TBHP to generate acids.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1736O – PubChem

The Absolute Best Science Experiment for 5-(2-Bromoethyl)-2,3-dihydrobenzofuran

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The present invention relates to novel and improved processes for the preparation of intermediates of darifenacin, darifenacin and its pharmaceutically acceptable salts. Darifenacin is chemically known as 3 -(S)-(-)-(l -carbamoyl- 1,1 -diphenylmethyl)-l- [2- (2,3-dihydro benzofuran-5-yl)ethyl]pyrrolidine and represented by formula-2. The invention also relates to the novel polymorphs of the pharmaceutically acceptable salts of darifenacin and the methods for their re aration.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3832O – PubChem

Awesome and Easy Science Experiments about 496-41-3

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A series of N-(2-methoxyphenyl)homopiperazine analogs was prepared and their affinities for dopamine D2, D3, and D4 receptors were measured using competitive radioligand binding assays. Several ligands exhibited high binding affinity and selectivity for the D3 dopamine receptor compared to the D2 receptor subtype. Compounds 11a, 11b, 11c, 11f, 11j and 11k had Ki values ranging from 0.7 to 3.9 nM for the D3 receptor with 30- to 170-fold selectivity for the D 3 versus D2 receptor. Calculated log P values (log P = 2.6-3.6) are within the desired range for passive transport across the blood-brain barrier. When the binding and the intrinsic efficacy of these phenylhomopiperazines was compared to those of previously published phenylpiperazine analogues, it was found that (a) affinity at D2 and D3 dopamine receptors generally decreased, (b) the D3 receptor binding selectivity (D2:D3 Ki value ratio) decreased and, (c) the intrinsic efficacy, measured using a forskolin-dependent adenylyl cyclase inhibition assay, generally increased.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1873O – PubChem

Discovery of 4265-25-2

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Application of 4265-25-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.4265-25-2, Name is 2-Methylbenzofuran, molecular formula is C9H8O. In a article,once mentioned of 4265-25-2

Volatile components in Dalbergia cochinchinensis Pierre were analysed using a comprehensive two-dimensional gas chromatography with mass spectrometry method featuring a new solid-state modulator. Compared to one-dimensional gas chromatography, the number of detected peaks were significantly increased. A total of 45 major compounds were identified in this study and the forward and reverse match factors of these compounds were both above 800. The results showed that the volatile components in Dalbergia cochinchinensis Pierre were primarily aldehyde?and ketone compounds such as benzaldehyde, cinnamaldehyde, 4-chromanone, 1-(2-hydroxyphenyl)ethanone and acetophenone. In addition, a semi-quantitative analysis was conducted to determine the contents of the detected compounds based on peak area percentage. Moreover, the repeatability of the comprehensive two-dimensional gas chromatography-mass spectrometry analysis in this study was quite satisfactory with relative standard deviations less than 12.7% for intraday and 17.3% for interday measurements.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H326O – PubChem

Can You Really Do Chemisty Experiments About 16859-59-9

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Related Products of 16859-59-9, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 16859-59-9, 3-Hydroxyisobenzofuran-1(3H)-one, introducing its new discovery.

A new protecting group has been developed for the exocyclic amino groups of nucleosides that occur in DNA. 3-Phenyl-[{N-(2-trimethylsilyl-ethoxycarbonyl)- 2-amino}]-propanoic acid used as the protective agent.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1509O – PubChem

Brief introduction of Benzo[b]furan-2-carboxaldehyde

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Plinabulin, a synthetic analog of the marine natural product ?diketopiperazine phenylahistin,? displayed depolymerization effects on microtubules and targeted the colchicine site, which has been moved into phase III clinical trials for the treatment of non-small cell lung cancer (NSCLC) and the prevention of chemotherapy-induced neutropenia (CIN). To develop more potent anti-microtubule and cytotoxic derivatives, the co-crystal complexes of plinabulin derivatives were summarized and analyzed. We performed further modifications of the tert-butyl moiety or C-ring of imidazole-type derivatives to build a library of molecules through the introduction of different groups for novel skeletons. Our structure?activity relationship study indicated that compounds 17o (IC50 = 14.0 nM, NCI-H460) and 17p (IC50 = 2.9 nM, NCI-H460) with furan groups exhibited potent cytotoxic activities at the nanomolar level against various human cancer cell lines. In particular, the 5-methyl or methoxymethyl substituent of furan group could replace the alkyl group of imidazole at the 5-position to maintain cytotoxic activity, contradicting previous reports that the tert-butyl moiety at the 5-position of imidazole was essential for the activity of such compounds. Immunofluorescence assay indicated that compounds 17o and 17p could efficiently inhibit microtubule polymerization. Overall, the novel furan-diketopiperazine-type derivatives could be considered as a potential scaffold for the development of anti-cancer drugs.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H802O – PubChem