Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application In Synthesis of Benzo[b]furan-2-carboxaldehyde, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4265-16-1, in my other articles.
One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Application In Synthesis of Benzo[b]furan-2-carboxaldehyde, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 4265-16-1, Name is Benzo[b]furan-2-carboxaldehyde, molecular formula is C9H6O2
Plinabulin, a synthetic analog of the marine natural product ?diketopiperazine phenylahistin,? displayed depolymerization effects on microtubules and targeted the colchicine site, which has been moved into phase III clinical trials for the treatment of non-small cell lung cancer (NSCLC) and the prevention of chemotherapy-induced neutropenia (CIN). To develop more potent anti-microtubule and cytotoxic derivatives, the co-crystal complexes of plinabulin derivatives were summarized and analyzed. We performed further modifications of the tert-butyl moiety or C-ring of imidazole-type derivatives to build a library of molecules through the introduction of different groups for novel skeletons. Our structure?activity relationship study indicated that compounds 17o (IC50 = 14.0 nM, NCI-H460) and 17p (IC50 = 2.9 nM, NCI-H460) with furan groups exhibited potent cytotoxic activities at the nanomolar level against various human cancer cell lines. In particular, the 5-methyl or methoxymethyl substituent of furan group could replace the alkyl group of imidazole at the 5-position to maintain cytotoxic activity, contradicting previous reports that the tert-butyl moiety at the 5-position of imidazole was essential for the activity of such compounds. Immunofluorescence assay indicated that compounds 17o and 17p could efficiently inhibit microtubule polymerization. Overall, the novel furan-diketopiperazine-type derivatives could be considered as a potential scaffold for the development of anti-cancer drugs.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application In Synthesis of Benzo[b]furan-2-carboxaldehyde, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4265-16-1, in my other articles.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H802O – PubChem