Brief introduction of 57830-14-5

As the paragraph descriping shows that 57830-14-5 is playing an increasingly important role.

57830-14-5, 5-Phenoxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57830-14-5, 5-phenoxyisobenzofuran-1(3H)-one (1.0g, 4.42mmol), xylene 10mL, benzyl triethyl ammonium chloride (300 mg, 1.32 mmol) and boron trifluoride diethyl ether (200 mg, 1.41 mmol) were added to the reaction flask, and the mixture was heated to 100 C dropwise to add thionyl chloride (5.0 g, 42.03 mmol). The reaction was carried out at 135 C for 5 hours. After the reaction was completed by thin layer chromatography, the filtrate was concentrated under reduced pressure. The filtrate was concentrated to 3 mL of methanol. The mixture was stirred at 55 C for 1 hour, then concentrated to dryness under reduced pressure. The potassium carbonate solution and the sodium chloride solution were washed and concentrated to dryness to give the title compound 2c (1.0 g, 83.0%).Used directly in the next step.

As the paragraph descriping shows that 57830-14-5 is playing an increasingly important role.

Reference:
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Cai Jiaqiang; Xie Yinong; You Zejin; Song Changwei; Zhang Jichao; Li Lu; Zhang Qiaoling; Wang Yongqiang; Chen Xing; Jiao Shihu; Li Youqiang; Wang Tao; Zeng Hong; Song Hongmei; Ye Qijun; Su Donghai; Zhou Xin; Zhang Shaohua; Wang Lichun; Wang Jingyi; (122 pag.)CN108341777; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 23405-32-5

As the paragraph descriping shows that 23405-32-5 is playing an increasingly important role.

23405-32-5, Methyl 1-oxo-1,3-dihydroisobenzofuran-5-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 2 was converted to 1,3-dihydro-1-oxoisobenzofuran-5-carbohydrazide (3) by reacting with hydrazine hydrate in methanol. To a mixture of methyl-1,3-dihydro-1-oxoisobenzofuran-5-carboxylate (2, 5.2 mmol) and methanol (5 mL) at 20-25 C, hydrazine hydrate (5 mL) was added. The reaction mass was refluxed for 4 h and the reaction completion was monitored by TLC. The reaction mass was filtered, washed with water followed by methanol and finally dried to get the pure product. White colour solid, yield: 98 %, m.p.: 220-230 C. IR (KBr, numax, cm-1): 3284 (-NH), 3178 (-NH2), 3053 (-CH), 1759 (lactone C=O), 1644 (amide C=O), 1045 (C-O); 1H NMR (400 MHz, DMSO-d6) delta ppm: 5.44 (2H, d, CH2), 7.41 (1H, m, ArH), 7.72 (1H, m, ArH), 8.01 (1H, dd, ArH), 9.81 (1H, s, CONH), 4.50 (2H, -NH2); 13C NMR (100 MHz, DMSO-d6) delta ppm: 170.2, 164.5, 144.8, 134.8, 128.7, 127.6, 126.4, 123.8, 60.6. LC-MS: m/z: 192 [M]+, 193 [M+1]+. Elemental analysis of C9H8N2O3 calcd. (found) %: C, 56.28 (56.23); H, 4.20 (4.20); N, 14.58 (14.58); O, 24.98 (24.99)., 23405-32-5

As the paragraph descriping shows that 23405-32-5 is playing an increasingly important role.

Reference:
Article; Rao, Nunna Madhava; Viveka, Tella Lakshmi; Raju, Koneti Mallikarjuna; Chary, Maringanti Thirumala; Asian Journal of Chemistry; vol. 32; 1; (2020); p. 95 – 100;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 374706-07-7

374706-07-7, The synthetic route of 374706-07-7 has been constantly updated, and we look forward to future research findings.

374706-07-7, 1-(2,3-Dihydrobenzofuran-6-yl)ethanone is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The title compound was prepared according to procedures reported in the literature and known by persons skill in the art, using 1-(2,3-dihydrobenzofuran-6-yl)ethan-1-one (0.6 g, 3.7 mmol) as starting material. In a preferred method, to a stirred solution of 1-(2,3-dihydrobenzofuran-6-yl)ethan-1-one (0.6 g, 3.7 mmol) in methanol (10 mL), sodium borohydride (281 mg, 7.4 mmol) was added slowly at 0 C and stirred 1.5 h. The completion of the reaction was monitored by TLC and the solvents were evaporated at 45 C under vacuum. The residue was diluted with EtOAc (25 mL) and washed with water (25 mL), brine solution (25 mL) and dried over Na2SO4. After evaporation of the solvent, the title compound was isolated and used without further purification. Yield: 88.30% (0.53 g, colourless liquid). 1H NMR (400 MHz, DMSO-d6): delta 7.1 1 (d, J = 7.6 Hz, 1H), 6.77-6.75 (m, 1 H), 6.71 (s, 1H), 5.04 (d, J = 4.4 Hz, 1H), 4.63-4.61 (m, 1H), 4.48 (t, J = 8.8 Hz, 2H), 3.1 1 (t, J = 8.8 Hz, 2H), 1 .25 (d, J = 6.4 Hz, 3H). LCMS: (Method A) 147.0 (M-17H), Rt. 2.64 min, 89.95% (Max).

374706-07-7, The synthetic route of 374706-07-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; KOEK, Johannes Nicolaas; (64 pag.)WO2017/144635; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 1646-26-0

1646-26-0, 1646-26-0 2-Acetylbenzofuran 15435, abenzofuran compound, is more and more widely used in various fields.

1646-26-0, 2-Acetylbenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of acetophenone (100 mg, 1 equiv) or phenylacetylene (1 equiv) in dioxane (5 mL), Oxone (2 equiv) and TFA (2 equiv) were added. The mixture was then heated to reflux for 10 h and then cooled to r.t. H2O (10 mL) was added and the mixture was extracted with EtOAc (2 × 20 mL). The combined organic layers were treated with sat. NaHCO3 solution and the aqueous layer was poured onto crushed ice and treated with 2 M HCl; a colorless solid precipitated out. The precipitate was filtered off and dried in vacuo to give benzoic acid (3a) after column chromatography (silica gel; EtOAc-hexane, 1:9) as a white crystalline solid; yield: 0.096 g (95%) from 1a; mp 122-123 C.

1646-26-0, 1646-26-0 2-Acetylbenzofuran 15435, abenzofuran compound, is more and more widely used in various fields.

Reference:
Article; Aravinda Kumar; Venkateswarlu, Vunnam; Vishwakarma, Ram A.; Sawant, Sanghapal D.; Synthesis; vol. 47; 20; (2015); p. 3161 – 3168;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 1646-26-0

1646-26-0, 1646-26-0 2-Acetylbenzofuran 15435, abenzofuran compound, is more and more widely used in various fields.

1646-26-0, 2-Acetylbenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of acetophenone (100 mg, 1 equiv) or phenylacetylene (1 equiv) in dioxane (5 mL), Oxone (2 equiv) and TFA (2 equiv) were added. The mixture was then heated to reflux for 10 h and then cooled to r.t. H2O (10 mL) was added and the mixture was extracted with EtOAc (2 × 20 mL). The combined organic layers were treated with sat. NaHCO3 solution and the aqueous layer was poured onto crushed ice and treated with 2 M HCl; a colorless solid precipitated out. The precipitate was filtered off and dried in vacuo to give benzoic acid (3a) after column chromatography (silica gel; EtOAc-hexane, 1:9) as a white crystalline solid; yield: 0.096 g (95%) from 1a; mp 122-123 C.

1646-26-0, 1646-26-0 2-Acetylbenzofuran 15435, abenzofuran compound, is more and more widely used in various fields.

Reference:
Article; Aravinda Kumar; Venkateswarlu, Vunnam; Vishwakarma, Ram A.; Sawant, Sanghapal D.; Synthesis; vol. 47; 20; (2015); p. 3161 – 3168;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 1646-26-0

1646-26-0, 1646-26-0 2-Acetylbenzofuran 15435, abenzofuran compound, is more and more widely used in various fields.

1646-26-0, 2-Acetylbenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of acetophenone (100 mg, 1 equiv) or phenylacetylene (1 equiv) in dioxane (5 mL), Oxone (2 equiv) and TFA (2 equiv) were added. The mixture was then heated to reflux for 10 h and then cooled to r.t. H2O (10 mL) was added and the mixture was extracted with EtOAc (2 × 20 mL). The combined organic layers were treated with sat. NaHCO3 solution and the aqueous layer was poured onto crushed ice and treated with 2 M HCl; a colorless solid precipitated out. The precipitate was filtered off and dried in vacuo to give benzoic acid (3a) after column chromatography (silica gel; EtOAc-hexane, 1:9) as a white crystalline solid; yield: 0.096 g (95%) from 1a; mp 122-123 C.

1646-26-0, 1646-26-0 2-Acetylbenzofuran 15435, abenzofuran compound, is more and more widely used in various fields.

Reference:
Article; Aravinda Kumar; Venkateswarlu, Vunnam; Vishwakarma, Ram A.; Sawant, Sanghapal D.; Synthesis; vol. 47; 20; (2015); p. 3161 – 3168;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 374706-07-7

374706-07-7, The synthetic route of 374706-07-7 has been constantly updated, and we look forward to future research findings.

374706-07-7, 1-(2,3-Dihydrobenzofuran-6-yl)ethanone is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The title compound was prepared according to procedures reported in the literature and known by persons skill in the art, using 1-(2,3-dihydrobenzofuran-6-yl)ethan-1-one (0.6 g, 3.7 mmol) as starting material. In a preferred method, to a stirred solution of 1-(2,3-dihydrobenzofuran-6-yl)ethan-1-one (0.6 g, 3.7 mmol) in methanol (10 mL), sodium borohydride (281 mg, 7.4 mmol) was added slowly at 0 C and stirred 1.5 h. The completion of the reaction was monitored by TLC and the solvents were evaporated at 45 C under vacuum. The residue was diluted with EtOAc (25 mL) and washed with water (25 mL), brine solution (25 mL) and dried over Na2SO4. After evaporation of the solvent, the title compound was isolated and used without further purification. Yield: 88.30% (0.53 g, colourless liquid). 1H NMR (400 MHz, DMSO-d6): delta 7.1 1 (d, J = 7.6 Hz, 1H), 6.77-6.75 (m, 1 H), 6.71 (s, 1H), 5.04 (d, J = 4.4 Hz, 1H), 4.63-4.61 (m, 1H), 4.48 (t, J = 8.8 Hz, 2H), 3.1 1 (t, J = 8.8 Hz, 2H), 1 .25 (d, J = 6.4 Hz, 3H). LCMS: (Method A) 147.0 (M-17H), Rt. 2.64 min, 89.95% (Max).

374706-07-7, The synthetic route of 374706-07-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; KOEK, Johannes Nicolaas; (64 pag.)WO2017/144635; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 57830-14-5

57830-14-5 5-Phenoxyisobenzofuran-1(3H)-one 44558580, abenzofuran compound, is more and more widely used in various fields.

57830-14-5, 5-Phenoxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,57830-14-5

102351 A reactor was charged with toluene (24 Kg), and stirring was initiated. The reactor was then charged with 5-phenoxyphthalide (56 Kg), thionyl chloride (41 Kg), trimethyl borate (1 Kg), dichlorotriphenylphosphorane (2.5 Kg), and potassium carbonate (77 Kg). The mixture was heated to reflux until reaction completion and solvent was removed leaving 2-chloromethyl-4-phenoxybenzoylchloride. Methanol was charged and the mixture was heated above 50 C until reaction completion. Solvent was removed and replaced with DMF. This solution of the product methyl 2-chloromethyl-4- phenoxybenzoic acid methyl ester in DMF was used directly in the next step (HPLC: 85%).

57830-14-5 5-Phenoxyisobenzofuran-1(3H)-one 44558580, abenzofuran compound, is more and more widely used in various fields.

Reference:
Patent; FIBROGEN, INC.; THOMPSON, Michael D.; PARK, Jung Min; AREND, Michael P.; WO2014/14834; (2014); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 57830-14-5

57830-14-5 5-Phenoxyisobenzofuran-1(3H)-one 44558580, abenzofuran compound, is more and more widely used in various fields.

57830-14-5, 5-Phenoxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,57830-14-5

102351 A reactor was charged with toluene (24 Kg), and stirring was initiated. The reactor was then charged with 5-phenoxyphthalide (56 Kg), thionyl chloride (41 Kg), trimethyl borate (1 Kg), dichlorotriphenylphosphorane (2.5 Kg), and potassium carbonate (77 Kg). The mixture was heated to reflux until reaction completion and solvent was removed leaving 2-chloromethyl-4-phenoxybenzoylchloride. Methanol was charged and the mixture was heated above 50 C until reaction completion. Solvent was removed and replaced with DMF. This solution of the product methyl 2-chloromethyl-4- phenoxybenzoic acid methyl ester in DMF was used directly in the next step (HPLC: 85%).

57830-14-5 5-Phenoxyisobenzofuran-1(3H)-one 44558580, abenzofuran compound, is more and more widely used in various fields.

Reference:
Patent; FIBROGEN, INC.; THOMPSON, Michael D.; PARK, Jung Min; AREND, Michael P.; WO2014/14834; (2014); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 23405-32-5

23405-32-5, 23405-32-5 Methyl 1-oxo-1,3-dihydroisobenzofuran-5-carboxylate 23299433, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23405-32-5,Methyl 1-oxo-1,3-dihydroisobenzofuran-5-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: Isobenzofuran-1(3H)-one (0.4 mmol), KOH (0.4 mmol), PhSiH3 (1.2 mmol), dried THF (2 mL) were charged in a Schlenk tube(15 mL) under N2 atmosphere. The mixture was refluxed for 4 h. After cooling to rt, the reaction was quenched with EtOH(0.5-1 mL). Solvent was removed under reduced pressure and the crude residue was purified by column chromatography on silica gel with petroleum ether-ethyl acetate as the eluent to afford the desired product.

23405-32-5, 23405-32-5 Methyl 1-oxo-1,3-dihydroisobenzofuran-5-carboxylate 23299433, abenzofuran compound, is more and more widely used in various fields.

Reference:
Article; Liu, Bin; Zhou, Xigeng; Chinese Chemical Letters; vol. 30; 3; (2019); p. 725 – 728;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem