Downstream synthetic route of 1646-26-0

1646-26-0, 1646-26-0 2-Acetylbenzofuran 15435, abenzofuran compound, is more and more widely used in various fields.

1646-26-0, 2-Acetylbenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of acetophenone (100 mg, 1 equiv) or phenylacetylene (1 equiv) in dioxane (5 mL), Oxone (2 equiv) and TFA (2 equiv) were added. The mixture was then heated to reflux for 10 h and then cooled to r.t. H2O (10 mL) was added and the mixture was extracted with EtOAc (2 × 20 mL). The combined organic layers were treated with sat. NaHCO3 solution and the aqueous layer was poured onto crushed ice and treated with 2 M HCl; a colorless solid precipitated out. The precipitate was filtered off and dried in vacuo to give benzoic acid (3a) after column chromatography (silica gel; EtOAc-hexane, 1:9) as a white crystalline solid; yield: 0.096 g (95%) from 1a; mp 122-123 C.

1646-26-0, 1646-26-0 2-Acetylbenzofuran 15435, abenzofuran compound, is more and more widely used in various fields.

Reference:
Article; Aravinda Kumar; Venkateswarlu, Vunnam; Vishwakarma, Ram A.; Sawant, Sanghapal D.; Synthesis; vol. 47; 20; (2015); p. 3161 – 3168;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem