With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23405-32-5,Methyl 1-oxo-1,3-dihydroisobenzofuran-5-carboxylate,as a common compound, the synthetic route is as follows.
General procedure: Isobenzofuran-1(3H)-one (0.4 mmol), KOH (0.4 mmol), PhSiH3 (1.2 mmol), dried THF (2 mL) were charged in a Schlenk tube(15 mL) under N2 atmosphere. The mixture was refluxed for 4 h. After cooling to rt, the reaction was quenched with EtOH(0.5-1 mL). Solvent was removed under reduced pressure and the crude residue was purified by column chromatography on silica gel with petroleum ether-ethyl acetate as the eluent to afford the desired product.
23405-32-5, 23405-32-5 Methyl 1-oxo-1,3-dihydroisobenzofuran-5-carboxylate 23299433, abenzofuran compound, is more and more widely used in various fields.
Reference：
Article; Liu, Bin; Zhou, Xigeng; Chinese Chemical Letters; vol. 30; 3; (2019); p. 725 – 728;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem