On July 21, 2005, Nilsson, Magnus; Zhou, Xiao-Xiong; Oden, Lourdes; Classon, Bjorn; Noren, Rolf; Grabowska, Urszula; Jackson, Philip; Fallon, Philip; Carr, Andrew; Liley, Mark; Tozer, Matt; Johnson, Tony; Diaz, Victor; Crespo, Laia; Kangasmetsa, Jussi; Bonnaud, Thierry published a patent.Recommanded Product: Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate The title of the patent was Preparation of N- oxohexahydrofuropyrrole amino acid amides as cathepsin K inhibitors.. And the patent contained the following:
Title compounds [I; 1 of R1, R2 = halo, the other = H, halo; R3 = (fluoro)alkyl; R4 = H; R3R4C = (substituted) spirocycloalkyl, heterocyclyl; R5 = H, Me; E = CO, SOm, NR5SOm, NR5CO, CO2; R6 = stable (substituted) mono- or bicyclic carbocyclyl, heterocyclyl; m = 0-2], were prepared Thus, title compound (II) (multistep preparation given) inhibited cathepsin K with Ki = 5.3 nM. The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Recommanded Product: Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate
The Article related to oxohexahydrofuropyrrole amino acid amide preparation cathepsin k inhibitor, osteoporosis gingivitis periodontitis pagets disease treatment amino acid amide, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Recommanded Product: Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem