Reiser, Ulrich et al. published their patent in 2013 |CAS: 60770-67-4

The Article related to alkynylpyridine preparation smac mimetic antitumor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 60770-67-4

On August 29, 2013, Reiser, Ulrich; Bader, Gerd; Spevak, Walter; Steffen, Andreas; Parkes, Alastair L. published a patent.Recommanded Product: 60770-67-4 The title of the patent was Preparation of 5-alkynylpyridines as SMAC mimetics. And the patent contained the following:

This invention relates to 5-alkynyl-pyridines I [R1 = H or alkyl; R2, R21 = H, (fluoro)alkyl; R3 = (un)substituted C6-10 aryl, 5-14 membered heteroaryl; R4 = H, (un)substituted C6-10 aryl, 5-14 membered heteroaryl, etc.; R5 = H, halo, alkyl, etc.; or R4 and R5 taken together form C6-10 aryl, 5-14 membered heteroaryl], to their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. Over two-hundred compounds I were prepared E.g., a multi-step synthesis of II, starting from 5,6-dibromopyridin-2-amine and ethynyl-tri(propan-2-yl)silane, was described. Exemplified compounds I were tested in XIAP BIR3 and cIAP1 BIR3 binding assays (data given). The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Recommanded Product: 60770-67-4

The Article related to alkynylpyridine preparation smac mimetic antitumor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem