On May 22, 2009, Hong, Hui; Xu, Xiang; Yu, Jiaxin; Singh, Rajinder; Darwish, Ihab S.; Thota, Sambaiah published a patent.Electric Literature of 53724-96-2 The title of the patent was Preparation of phenylpiperidinyloxypyridine derivatives for use as therapeutic agents in metabolic disorders. And the patent contained the following:
Title compounds I [B = substituted aryl or heteroaryl; E = CO, SO2, or bond; T = alkyl-OR10, alkyl-C(O)R10, alkyl-S(O)p, etc.; Y = (un)substituted amine; each R4 independently = halo, CN. NO2, alkyl, etc.; or two R4 on the same carbon optionally combine to form oxo; R10 = H, alkyl, haloalkyl, etc.; m = 0 to 4; n = 0 to 3; p = 0 to 2; provided that when B = Ph, then E is not CO], and their pharmaceutically acceptable salts, are prepared and disclosed as therapeutic agents in metabolic disorders. Thus, e.g., II was prepared by deprotection of tert-Bu 1-(pyridin-4-ylmethyl)piperidin-4-ylcarbamate followed by amidation with 6-chloropicolinic acid, and etherification with 1-(4-(trifluoromethyl)phenyl)piperidin-4-ol. Select I were evaluated for their ability to activate AMPK using enzyme-linked immunosorbent assays, e.g., II demonstrated an EC50 value of 0.1-0.5 μM. The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Electric Literature of 53724-96-2
The Article related to pyridine phenylpiperidinyloxy derivative preparation metabolic disorder, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Electric Literature of 53724-96-2
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem