On March 10, 2010, Deng, Yong; Wu, Chenglong; Shen, Yi; Wan, Jie published a patent.Application of 60770-67-4 The title of the patent was Simple and green method for synthesis of (E)-3-(benzofuran-5-yl)acrylic acid ester. And the patent contained the following:
A process for preparation of (E)-3-(benzofuran-5-yl)acrylic acid ester from p-halophenol and 2-haloacetaldehyde or 2-haloacetal is disclosed. The claimed (E)-3-(benzofuran-5-yl)acrylic acid ester is shown in structure I (R = C1-12 alkyl or cycloalkyl, (un)substituted benzyl, allyl, (un)substituted C6-10 aryl). (E)-3-(benzofuran-5-yl)acrylic acid ester is prepared from p-halophenol and 2-haloacetaldehyde or 2-haloacetal via substitution reaction, Bronsted acid or Lewis acid catalyzed Friedel-Crafts reaction to form 5-halobenzofuran, further Heck reaction with acrylic acid ester to provide the title compound The obtained (E)-3-(benzofuran-5-yl)acrylic acid ester can be further reduced, hydrolyzed, or hydrogenized for give the corresponding derivatives The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Application of 60770-67-4
The Article related to benzofuranylacrylic acid ester preparation substitution friedel crafts heck, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Application of 60770-67-4
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem