Brief introduction of 10242-11-2

The synthetic route of 10242-11-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-11-2,5-Bromobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: Shikonin (1mmol), benzofuran-2-carboxylic acid derivatives (4a-4q) (3mmol), 4-dimethyaminopyridine (0.5mmol), and N, N?- dicyclohexylcarbodiimide (0.5mmol) were suspended in the anhydrous DCM (10ml). The reaction mixture was stirred for 8h under 0C. Afterwards, the targeted compounds 6a-6q were purified by column chromatography., 10242-11-2

The synthetic route of 10242-11-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kong, Ling-Yi; Leng, Jia-Fu; Lian, Bao-Ping; Shao, Yu-Ying; Xia, Yuan-Zheng; Yin, Yong; European Journal of Medicinal Chemistry; vol. 190; (2020);,
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Some tips on 174775-48-5

As the paragraph descriping shows that 174775-48-5 is playing an increasingly important role.

174775-48-5, Ethyl 5-aminobenzofuran-2-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Commercially available ethyl 5-NITROBENZOFURAN-2-CARBOXYLATE 30 was HYDROGENATED on PD-C and ACYLATED using commercially available 4-NITRO-N-METHYL-2- TRICHLOROACETYL-PYRROLE 32 to form 33. HYDROGENATION of 33 followed by acylation with 32 afforded the nitro compound 35, which upon HYDROGENATION yielded 36 as the amino compound. ACETYLATION of the amino group of 36 followed by base catalyzed hydrolysis resulted in the acid 37. Coupling of 37 with the hydrochloride salt 39 (obtained by DEPROTECTION of the BOC derivative 38) using EDC afforded the ester 40. See Figure 4., 174775-48-5

As the paragraph descriping shows that 174775-48-5 is playing an increasingly important role.

Reference£º
Patent; THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; WO2005/32594; (2005); A2;,
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Simple exploration of 115010-11-2

115010-11-2, 115010-11-2 2,3-Dihydro-1-benzofuran-5-sulfonoylchloride 2776154, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115010-11-2,2,3-Dihydro-1-benzofuran-5-sulfonoylchloride,as a common compound, the synthetic route is as follows.

Take compound IX-2 (300mg, 1.37mmol) in chlorobenzene (2mL),Add N-bromosuccinimide (244 mg, 1.37 mmol),Azobisisobutyronitrile (3mg),The temperature was raised to 80 C.After heating for 1.5 hours,Add N-bromosuccinimide (122 mg, 0.685 mmol),The reaction was monitored by TLC after 4 hours.After the reaction was cooled to room temperature, water (5 mL) was added.Ethyl acetate extraction (3mL x 3),Combined organic phases,Washed with saturated saline (3mL x 2),Dry over anhydrous sodium sulfate.The solvent was distilled off under reduced pressure,The residue was purified by column chromatography (petroleum ether / ethyl acetate = 50/1) to obtain compound XI-1 (yellow oil, 337 mg).

115010-11-2, 115010-11-2 2,3-Dihydro-1-benzofuran-5-sulfonoylchloride 2776154, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; China Pharmaceutical University; Sun Hongbin; Yan Dingfei; Feng Zhiqi; Zhang Jia; Yao Zhiying; Zhao Wenfeng; Zhang Xiangying; Sun Geng; Han Lishuai; Wu Wenzhen; Liu Shengjie; Zhao Xing; Li Minglei; Yu Shengqi; Chen Hui; Cheng Yalong; Wang Pengfei; Dai Liang; Wen Xiaoan; Liu Jun; (102 pag.)CN110372638; (2019); A;,
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Analyzing the synthesis route of 28418-88-4

28418-88-4, As the paragraph descriping shows that 28418-88-4 is playing an increasingly important role.

28418-88-4, 4-Iodoisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Iodophthalic anhydride (598 mg, 2.18 mmol) was dissolved in DMF (14 mL), and the solution was added with an aqueous solution (10 mL) of hexamethyldisilazane (HMDS) (4.6 mL, 22 mmol) and methanol (0.44 mL, 11 mmol), followed by stirring at room temperature for 18.5 hours. The reaction mixture was added with water and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressurea and the residue was purified by slurry using chloroform to obtain 3-iodophtalimide (403 mg, yield 68%). APCI-MS m/z: 272 [M-H]-; 1H-NMR (DMSO-d6)delta(ppm): 7.53 (dd, J = 7.4, 7.8 Hz, 1H), 7.84 (dd, J = 0.6, 7.3 Hz, 1H), 8.22 (dd, J = 0.6, 7.8 Hz, 1H), 11.52 (br s, 1H).

28418-88-4, As the paragraph descriping shows that 28418-88-4 is playing an increasingly important role.

Reference£º
Patent; Kyowa Hakko Kirin Co., Ltd.; EP2108642; (2009); A1;,
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Downstream synthetic route of 127264-14-6

127264-14-6, As the paragraph descriping shows that 127264-14-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

Example 15:Preparation of (S)-2,2-diphenyl-2-{l-[2-(2,3-dihydrobenzofuran-5yl)-ethyl]- pyrrolidin-3yl} acetic acid methyl ester: A mixture of 3-(S)-2,2-diphenyl-2-pyrrolidinyl-3yl-acetic acid methyl ester(29.5 grams), 5-(2-bromoethyl)2,3-dihydrobenzo[2,3-b]furan (22.7 grams), anhydrous potassium carbonate (27.6 grams) and acetonitrile (300 ml) was heated to reflux and stirred for 60 min. The mixture was partitioned between methylene chloride (250 ml) and 10percent aqueous potassium carbonate (250 ml). The two layers were separated and the aqueous layer was extracted with methylene chloride. The organic layer was dried with sodium sulphate and distilled off the organic layer under reduced pressure followed by triturating with ethyl acetate to get the title compound. Yield: 30.5 grams

127264-14-6, As the paragraph descriping shows that 127264-14-6 is playing an increasingly important role.

Reference£º
Patent; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; VENKATESH, Mummadi; WO2008/126106; (2008); A2;,
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New learning discoveries about 28418-88-4

28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

28418-88-4, 4-Iodoisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

28418-88-4, SYNTHESIS EXAMPLE 7-1 To a solution of 3-iodophthalic anhydride (32.5 g) in dimethylformamide (300 mL), a solution of (2S)-1-(methylthio)propan-2-amine (15.0 g) in dimethylformamide (50 mL) was added dropwise at -10 C. for 3 hours, and the mixture was stirred at -10 C. for additional 3 hours. After addition of 40% sodium hydroxide aqueous solution (15 g), the solvent was distilled off under reduced pressure, and the crude product was dissolved in water (500 mL) and washed with diisopropyl ether. The water phase was separated, adjusted to pH 1 with concentrated hydrochloric acid and extracted with diisopropyl ether. The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was distilled off, and the resulting crude crystal was washed with a small amount of diisopropyl ether and air-dried to obtain 3-iodo-2-{[(1S)-1-methyl-2-(methylthio)ethyl]-carbamoyl}benzoic acid (32.2 g). Melting point: 132-134 C.

28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer CropScience AG; US2011/184188; (2011); A1;,
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Some tips on 143878-29-9

The synthetic route of 143878-29-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.143878-29-9,Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate,as a common compound, the synthetic route is as follows.

Crude methyl 4-acetylamino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylate (125 g), obtained in the above step-3, and methanol (531.6 ml) were taken into a reaction flask at 25-30C and the contents were stirred for 10 minutes at the same temperature. To the resulting mass, a mixture of sodium hydroxide (15.8 g) and water (98 ml) was added at 25- 30C, followed by stirring the mixture for 10 minutes at the same temperature. The resulting mass was heated to 50-55C and then stirred for 2 hours at the same temperature. The resulting solution was cooled to 0-5C and then stirred for 1 hour at the same temperature. The separated solid was filtered and washed with chilled methanol (50 ml) to produce 30 g of 4-acetylamino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid sodium salt (Purity by HPLC: 98.2%)., 143878-29-9

The synthetic route of 143878-29-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SYMED LABS LIMITED; MOHAN RAO, Dodda; VENUGOPAL, Bingi; (46 pag.)WO2017/137910; (2017); A1;,
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Analyzing the synthesis route of 286836-04-2

As the paragraph descriping shows that 286836-04-2 is playing an increasingly important role.

286836-04-2, 5-Bromo-7-fluorobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 28 (5-bromo-7-fluorobenzofuran, was added to the reaction vessel.5.0 g, 23.2 mmol), compound 13 (4,4,5,5-tetramethyl-2-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)-1,3, 2-dioxaborolan,6.4 g, 21.0 mmol), toluene (64.0 mL, 10 mL/g),Methanol (6.4 mL, 1 mL/g).After adding Cs2CO3 (13.7 g, 42.0 mmol),Pd(PPh3)4 (1.2 g, 1.1 mmol) was added under a nitrogen atmosphere.The reaction was carried out by refluxing at 120 C for 3 hours.After the reaction, the reaction is cooled to normal temperature.And filtered with celite using ethyl acetate.The filtered solution is washed with brine.It was then dried over anhydrous sodium sulfate and filtered and evaporated.The concentrate was subjected to silica gel column chromatography (hexane:EtOAc = 7:1)Purification to give a white solid compound 29(5.2 g, yield 71.6%)., 286836-04-2

As the paragraph descriping shows that 286836-04-2 is playing an increasingly important role.

Reference£º
Patent; Dongjin Shimeiken Co., Ltd.; Cui Zhenyu; Jiang Bingnan; Yin Xingyi; Song Zhenyin; Jin Xingxie; Li Dongxuan; Cui Zhien; Li Xuanzhi; Shen Guichun; (45 pag.)CN109206387; (2019); A;,
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Analyzing the synthesis route of 28418-88-4

As the paragraph descriping shows that 28418-88-4 is playing an increasingly important role.

28418-88-4, 4-Iodoisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0592] To a solution of 4-iodoisobenzofuran-1,3-dione (2.97 g, 10.84 mmol) and (S)-3-aminoazepan-2-one (1.39 g, 10.84 mmol) in ACN (15 mL) and AcOH (21 mL) at rt. The suspension was heated to 80 C and stirred overnight. Cooled to rt, sodium acetate (2.22 g, 27.1 mmol) and AcOH (10 mL) were added. The reaction mixture was heated to 80 C and stirred overnight. TLC showed the starting material was consumed and a new spot was present. Upon removal of the solvent, the residue was diluted with water (8 mL) and stirred 30 minutes. The mixture was extracted with EA and concentrated providing (S)-4-iodo-2-(2- oxoazepan-3-yl)isoindoline-1,3-dione (2.4 g, 57.7% yield) as a white solid. MS (ESI) m/z = 385 [M+H]+., 28418-88-4

As the paragraph descriping shows that 28418-88-4 is playing an increasingly important role.

Reference£º
Patent; BIOTHERYX, INC.; CHAN, Kyle, W.H.; FUNG, Leah; SULLIVAN, Robert; ERDMAN, Paul, E.; MERCURIO, Frank; (225 pag.)WO2017/201069; (2017); A1;,
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Some tips on 127264-14-6

127264-14-6, 127264-14-6 5-(2-Bromoethyl)-2,3-dihydrobenzofuran 21831160, abenzofuran compound, is more and more widely used in various fields.

127264-14-6, 5-(2-Bromoethyl)-2,3-dihydrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The bromo compound 3 (4.54 g, 0.02 mol) and 3-(R)-(1-carbamoyl-1,1-diphenylmethyl)-pyrrolidine (4, 5.6 g, 0.02 mol) were refluxed in acetonitrile containing KOH (1.12 g, 0.02 mol). The reaction mixture was distilled off, water (50 mL) and MDC (50 mL) was added to the obtained residue to form a two-phase mixture. The phases were separated and organic phase was distilled under vacuum. The obtained residue was dissolved in methyl ethyl ketone (10 mL) and filtered to eliminate un-dissolved solid. The 48percent HBr (0.344 g, 0.00204 mol) was added to the filtrate and distilled under vacuum to afford solid foam. The foam was scurried in diisopropylether and filtered to get the title compound in 7 g yield.

127264-14-6, 127264-14-6 5-(2-Bromoethyl)-2,3-dihydrobenzofuran 21831160, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Vasantha; Lakshmanarao; Srinivasa Rao; Sivalakshmi Devi; Venkata Suryanarayana; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 52; 6; (2013); p. 824 – 828;,
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