Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2923-28-6, is researched, SMILESS is O=S(C(F)(F)F)([O-])=O.[Ag+], Molecular CAgF3O3SJournal, Helvetica Chimica Acta called Probing BRD Inhibition Substituent Effects in Bulky Analogues of (+)-JQ1, Author is Hassell-Hart, Storm; Picaud, Sarah; Lengacher, Raphael; Csucker, Joshua; Millet, Regis; Gasser, Gilles; Alberto, Roger; Maple, Hannah; Felix, Robert; Lesnikowski, Zbigniew J.; Stewart, Helen J. S.; Chevassut, Timothy J.; Morley, Simon; Filippakopoulos, Panagis; Spencer, John, the main research direction is bromodomain inhibitor heterocyclic amide preparation ferrocene cyclopentadienylrhenium adamantane derivative; crystal structure bromodomain inhibitor heterocyclic amide.Reference of Silver(I) trifluoromethanesulfonate.
A series of bulky organometallic and organic analogs of the bromodomain (BRD) inhibitor (+)-JQ1, I [2a-e; R = ferrocenyl, (η5-CH2C5H2-3-CO2Et-4-Me)Re(CO)3, (CH2)3-p-C2B10H11, 1-adamantyl, 1-adamantylmethyl] have been prepared The most potent compound 2e (R = adamantylmethyl), showed excellent potency with an KD = ca. 130 nm vs. BRD4(1) and a ca. 2-fold selectivity over BRD4(2) (KD = ca. 260 nm). Its binding to the first bromodomain of BRD4 was determined by a protein cocrystal structure.
《Probing BRD Inhibition Substituent Effects in Bulky Analogues of (+)-JQ1》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Silver(I) trifluoromethanesulfonate)Reference of Silver(I) trifluoromethanesulfonate.