Vasorelaxing effect in rat thoracic aorta caused by fraxinellone and dictamine isolated from the Chinese herb Dictamnus dasycarpus Turcz: comparison with cromakalim and Ca2+ channel blockers was written by Yu, Sheu Meei;Ko, Feng Nien;Su, Ming Jai;Wu, Tian Shung;Wang, Meei Ling;Huang, Tur Fu;Teng, Che Ming. And the article was included in Naunyn-Schmiedeberg’s Archives of Pharmacology in 1992.Related Products of 28808-62-0 This article mentions the following:
The components of D. dasycarpus Turcz were tested for their vasorelaxing effect on the rat aorta, and fraxinellone (I) and dictamine (II) were shown to be effective vasorelaxants. In high K+ (60 mmol/L) medium, Ca2+ (0.03 to 3 mmol/L)-induced vasoconstriction was inhibited concentration-dependently by both agents. The IC50 for I and II were calculated to be about 25 μmol/L and 15 μmol/L (for Ca2+ concentration of 1 mmol/L), resp. Cromakalim (0.2-10 μmol/L) relaxed aortic rings precontracted with 15 but not 60 mmol/L of K+. I and verapamil were more potent and effective in producing relaxation in 60 mmol/L than in 15 mmol/L K+-induced contraction. However, II was more potent in producing relaxation in 15 mmol/L K+-induced contraction. Nifedipine (1 μmol/L), II (100 μmol/L) and I (100 μmol/L) relaxed the aortic contraction caused by KCl or Bay K 8644. The tonic contraction elicited by noradrenaline (NA, 3 μmol/L) was also relaxed by II (500 μmol/L), but not by I (500 μmol/L) in the nifedipine (1 μmol/L)-treated aorta. This relaxing effect of II persisted in endothelium-denuded aorta. Glibenclamide (10 μmol/L) shifted the concentration-relaxation curve of cromakalim, but not that of II, to the right in rat aortic rings precontracted with NA. II (500 μmol/L) did not affect tonic contraction of NA which are reduced by H-7 (1 μmol/L) in Ca2+-depleted medium. In conclusion, I is a selective blocker of voltage-dependent Ca2+ channel, while II relaxes the rat aorta by suppressing the Ca2+ influx through both voltage-dependent and receptor-operated Ca2+ channels. In the experiment, the researchers used many compounds, for example, (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0Related Products of 28808-62-0).
(3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Related Products of 28808-62-0
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem