Effects of fraxinellone on the peritrophic membrane of Mythimna separata(Lepidoptera:Noctuidae) was written by Lu, Min;Chen, Su-ying;Han, Li-bo;Hu, Jun-yun;Xu, Hui;Wu, Wen-jun. And the article was included in Kunchong Xuebao in 2014.Formula: C14H16O3 This article mentions the following:
Isolated from the root-bark of Diatamnus dasycarpus Turcz., fraxinellone exhibits stomach toxicity against pests. This study aims to clarify the insecticidal mechanism of fraxinellone by investigating the effects of fraxinellone on the peritrophic membrane of the 6th instar larvae of Mythimna separata. Through biochem. methods and SEM observation, the content of carbohydrates, the contents and components of proteins and the surface structure of the peritrophic membrane of the 6th instar larvae of M. separata after in vivo and in vitro treatments with fraxinellone were studied. In vivo treatment of fraxinellone (20 mg/mL) resulted in a drop of the protein content in the 6th instar larvae of M. separata. However, after M. separata larvae were subjected to in vivo (20 mg/mL fraxinellone) and in vitro (8 mg/mL fraxinellone) treatments with fraxinellone, the contents of carbohydrates of both treatments increased, which were 1.75 and 2.17 folds as high as those of the control, resp. SDS-PAGE result showed that partial proteins were hydrolyzed in the 6th instar larvae of M. separata subjected to in vivo and in vitro treatment with fraxinellone. SEM observation showed that the surface structure of peritrophic membrane changed after the 6th instar larvae of M. separata were treated with fraxinellone in vivo and in vitro. These results showed that fraxinellone affected the contents of carbohydrates and the contents and components of proteins, and altered the surface structure of the peritrophic membrane of M. separata larvae. This study provides a basis for further research on the insecticidal mechanisms of fraxinellone against pests. In the experiment, the researchers used many compounds, for example, (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0Formula: C14H16O3).
(3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C14H16O3
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem