Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.174775-48-5,Ethyl 5-aminobenzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of 1-(2,3-dichlorophenyl) piperazine (entry 3) (5 g, 0.022 mol) in THF (25 mL) was added formamide (2.4 g, 0.054 mol).To the above mixture was added sodium methoxide (30% solution in methanol, 9.7 g, 0.054 mol) and stirred at room temperature for 6 h. The solvent was evaporated and the reaction mixture was diluted with water and extracted with dichloromethane (50 mL ¡Á 2). The dichloromethane layer was washed with 25 mL of dilute HCl and concentrated under reduced pressure to give the product (5.1 g, 92%)., 174775-48-5

The synthetic route of 174775-48-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Joseph, Sony; Das, Prasenjit; Srivastava, Bindu; Nizar, Hashim; Prasad, Mohan; Tetrahedron Letters; vol. 54; 8; (2013); p. 929 – 931;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

5-(2-Bromoethyl)benzo[2,3-b]furan (17.2 g) was added to the mixture of 3-(S)- (+)-( 1 -carbamoyl- 1 , 1 -diphenylmethyl)pyrrolidine.L-(+)-tartrate (25 g), potassium hydroxide (11.4 g) in acetonitrile solvent at 25-35¡ã C. Reaction mass was heated to 40- 45¡ã C and maintained up to completion of the reaction . The reaction mass was then cooled to R.T and extracted with dichloromethane, the solvent distilled off under vacuum to give residue. Acetone was added to the residue and cooled to 10-15¡ã C. Hydrobromic acid was added to the above solution and heated to 20-25¡ã C and maintained for 10-12 hours. The reaction mass is filtered to give darifenacin hydrobromide., 127264-14-6

The synthetic route of 127264-14-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MATRIX LABORATOIRES LIMITED; WO2009/125430; (2009); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

6296-53-3, N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6296-53-3, [0110j A stirred solution of 1 -(3 -ethoxy-4-methoxyphenyl)-methylsulfonylethylamine (1.0 g, 3.7 mmol) and 3-acetamidophthalic anhydride (751 mg, 3.66 mmol) in acetic acid (20 mL) was heated at reflux for 15 h. The solvent was removed in vacuo to yield an oil. Chromatography of the resulting oil yielded the product as a yellow solid (1.0 g, 59% yield): mp, 144C.; ?H NMR (CDC13) oel.47 (t, J=7.0 Hz, 3H, CH3), 2.26 (s, 3H, CH3), 2.88 (s,3H, CH3),3.75 (dd, J4.4, 14.3 Hz, 1H, CHH), 3.85 (s, 3H, CH3), 4.11 (q, J 7Hz, 2H, CH2), 5.87 (dd, J4.3, 10.5 Hz, 1H, NCH), 6.82-6.86 (m, 1H, Ar), 7.09-7.11 (m, 2H, Ar), 7.47 (d, J= 7 Hz, 1H., Ar), 7.64 (t, J= 8 Hz, 1H, Ar), 8.74 (d, J= 8 Hz, 1H, Ar), 9.49 (br s, 1H, NH); ?3C NMR (CDC13) oe14.61, 24.85, 41.54, 48.44, 54.34, 55.85, 64.43, 111.37, 112.34, 115.04, 118.11, 120.21, 124.85, 129.17, 130.96, 136.01, 137.52, 148.54, 149.65, 167.38, 169.09, 169.40; Anal Calc?d. for C22H24N075: C, 57.38; H, 5.25; N, 6.08. Found: C, 57.31; H, 5.34; N, 5.83.

6296-53-3 N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide 226121, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; CELGENE CORPORATION; SCHAFER, Peter; KORISH, Shimon; (45 pag.)WO2015/175773; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

69604-00-8,69604-00-8, Ethyl 5-nitrobenzofuran-2-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example-2: preparation of ethyl-5-amino-l-benzofuran-2-carboxylate To a solution of ethyl-5-nitro- 1 -benzofuran-2-carboxylate (100g) in Ethyl acetate (800ml) was added 10% palladium on carbon (4.0g). The reaction mixture was stirred under an atmosphere of hydrogen at 33-38C with 4-5kg/cm2 hydrogen pressure for 4-6 hrs. After completion of the reaction, reaction mixture was filtered through hyflo, washed with ethyl acetate. The filtrate was concentrated in vacuo to give ethyl-5-amino-l-benzofuran-2- carboxylate yield: 100%

69604-00-8 Ethyl 5-nitrobenzofuran-2-carboxylate 1382954, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; ALEMBIC PHARMACEUTICALS LIMITED; JAYARAMAN, Venkat Raman; RATHOD, Dhiraj; VOHRA, Irfan; BHUJADE, Vinayak; MODI, Viral; GANDHI, Ojas; BUDH, Mayur; WO2013/153492; (2013); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

81742-10-1, 3,6-Dichlorotrimellitic Anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

81742-10-1, General procedure: Place 5 mL concentrated H2SO4 in a 50 mL round bottom flask and cool in an ice/water bath. Compound 20 (300 mg, 0.5 mmol) is added in portions, and the reaction mixture is stirred at room temperature until TLC shows complete consumption of compound 20. The mixture is added to the stirring Et2O solution (400 mL) at 0 C. The resulting precipitate is filtered, washed with EtOAc, and dried. The crude product is purified by RP-HPLC using TEAA/ACN give compound 5a (96 mg, 20%) and compound 5b (101 mg, 21%).

The synthetic route of 81742-10-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ying, Laiqiang; (22 pag.)US10513610; (2019); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.201809-69-0,6-Bromobenzofuran-3(2H)-one,as a common compound, the synthetic route is as follows.

[A] (rac)-6-Bromo-2,3-dihydro-benzofuran-3-ol To a solution of 6-bromo-benzofuran-3-one (10.5 g, 49.28 mmol) in methanol (100 ml) was added NaBH4 (2.37 g, 64.07 mmol) at 0 C. The reaction mixture was then stirred for 2 hours at room temperature. It was subsequently quenched with saturated ammonium chloride solution (50 ml) and extracted twice with ethyl acetate (2*50 ml). The combined organic phases were dried over Na2SO4 and evaporated under reduced pressure to give 9.75 g (92%) of the title compound as colorless liquid.

201809-69-0, As the paragraph descriping shows that 201809-69-0 is playing an increasingly important role.

Reference£º
Patent; Aebi, Johannes; Binggeli, Alfred; Hertel, Cornelia; Konkar, Anish Ashok; Kuehne, Holger; Kuhn, Bernd; Maerki, Hans P.; Wang, Haiyan; US2013/18055; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115010-11-2,2,3-Dihydro-1-benzofuran-5-sulfonoylchloride,as a common compound, the synthetic route is as follows.

INTERMEDIATE 55 7-Iodo-2, 3-dihydro-benzofuran-5-sulfonyl chloride A solution of ICl (7.7 g, 47 mmol) in DCM (100 mL) was added dropwise to a solution of 2,3-dihydro-benzofuran-5-sulfonyl chloride (5 g, 23 mmol; Intermediate 54) in DCM (100 mL) at reflux temperature under nitrogen atmosphere. The reaction was heated at reflux overnight. The reaction mixture was cooled at room temperature and acetonitrile (50 mL) was added. The resultant mixture was washed with a saturated solution of NaHC03 and the organic phase was separated followed by elimination of the volatiles under vacuum to give 8 g of brown oil which was used to the next step without further purification. 1H NMR 270 MHz (CDC13) 8 ppm 3.45 (t,. J=8. 91 Hz, 2 H) 4.82 (t, J=8. 91 Hz, 2 H) 7.79 (d, J=1. 48 Hz, 1 H) 8.16 (d, J=1. 98 Hz, 1 H).

115010-11-2, The synthetic route of 115010-11-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BIOVITRUM AB; WO2005/58858; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

123654-26-2, 4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a) Triethylamine (0.16 mol) was added to a solution of 4-amino-5-chloro-2,3-dihydro-7-benzofurancarboxylic acid (0.16 mol) in chloroform (600 ml) at a temperature below 10 C. Ethyl chloroformate (15.3 ml) was added afterwards and the reaction mixture was stirred for 45 minutes, while cooling on an ice-bath. Gaseous ammonia was allowed to bubble through the mixture and the reaction mixture was stirred for 3 hours at RT. The precipitate was filtered off and consecutively washed with water, 5% NaOH solution, and again water, and dried, yielding 23.5 g (69%) of 4-amino-5-chloro-2,3-dihydro-7-benzofurancarboxamide (intermediate 7)., 123654-26-2

As the paragraph descriping shows that 123654-26-2 is playing an increasingly important role.

Reference£º
Patent; Janssen Pharmaceutica N.V.; US5854261; (1998); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem