With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.174775-48-5,Ethyl 5-aminobenzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.
General procedure: To a stirred solution of 1-(2,3-dichlorophenyl) piperazine (entry 3) (5 g, 0.022 mol) in THF (25 mL) was added formamide (2.4 g, 0.054 mol).To the above mixture was added sodium methoxide (30% solution in methanol, 9.7 g, 0.054 mol) and stirred at room temperature for 6 h. The solvent was evaporated and the reaction mixture was diluted with water and extracted with dichloromethane (50 mL ¡Á 2). The dichloromethane layer was washed with 25 mL of dilute HCl and concentrated under reduced pressure to give the product (5.1 g, 92%)., 174775-48-5
The synthetic route of 174775-48-5 has been constantly updated, and we look forward to future research findings.
Article; Joseph, Sony; Das, Prasenjit; Srivastava, Bindu; Nizar, Hashim; Prasad, Mohan; Tetrahedron Letters; vol. 54; 8; (2013); p. 929 – 931;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem