With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.201809-69-0,6-Bromobenzofuran-3(2H)-one,as a common compound, the synthetic route is as follows.
[A] (rac)-6-Bromo-2,3-dihydro-benzofuran-3-ol To a solution of 6-bromo-benzofuran-3-one (10.5 g, 49.28 mmol) in methanol (100 ml) was added NaBH4 (2.37 g, 64.07 mmol) at 0 C. The reaction mixture was then stirred for 2 hours at room temperature. It was subsequently quenched with saturated ammonium chloride solution (50 ml) and extracted twice with ethyl acetate (2*50 ml). The combined organic phases were dried over Na2SO4 and evaporated under reduced pressure to give 9.75 g (92%) of the title compound as colorless liquid.
201809-69-0, As the paragraph descriping shows that 201809-69-0 is playing an increasingly important role.
Reference£º
Patent; Aebi, Johannes; Binggeli, Alfred; Hertel, Cornelia; Konkar, Anish Ashok; Kuehne, Holger; Kuhn, Bernd; Maerki, Hans P.; Wang, Haiyan; US2013/18055; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem