Category: 201809-69-0

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The invention discloses a having the following general formula (I) compound. The invention also disclosed comprising this compound JAK kinase inhibitor and the compounds in the preparation of the treatment in the JAK related diseases of the application. JAK kinase inhibitors of the present invention, can inhibit the signal transduction of the involved in various JAK1, JAK2, JAK3 and TYK2 kinase biological activity, can effectively clinical treatment of various inflammatory diseases and JAK-mediated signal transduction by the driving of various diseases, very broad application prospects. . (by machine translation)

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3576O – PubChem

Can You Really Do Chemisty Experiments About 6-Bromobenzofuran-3(2H)-one

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Related Products of 201809-69-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.201809-69-0, Name is 6-Bromobenzofuran-3(2H)-one, molecular formula is C8H5BrO2. In a article，once mentioned of 201809-69-0

GPR40 (FFAR1 or FFA1) is a G protein-coupled receptor, primarily expressed in pancreatic islet beta-cells and intestinal enteroendocrine cells. When activated by fatty acids, GPR40 elicits increased insulin secretion from islet beta-cells only in the presence of elevated glucose levels. Towards this end, studies were undertaken towards discovering a novel GPR40 Agonist whose mode of action is via Positive Allosteric Modulation of the GPR40 receptor (AgoPAM). Efforts were made to identify a suitable GPR40 AgoPAM tool molecule to investigate mechanism of action and de-risk liver toxicity of GPR40 AgoPAMs due to reactive acyl-glucuronide (AG) metabolites.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3577O – PubChem

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The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 201809-69-0 is helpful to your research. Related Products of 201809-69-0

Related Products of 201809-69-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 201809-69-0, molcular formula is C8H5BrO2, introducing its new discovery.

The invention provides novel compounds having the general Formula (I), wherein R1, R2, R3, R4 R5, R6, R7, R8 R9, R10, R11, R12, A1, A2 and n are as described herein, compositions including the compounds and methods of using the compounds.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3571O – PubChem

Some scientific research about 201809-69-0

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 201809-69-0, and how the biochemistry of the body works.Related Products of 201809-69-0

Related Products of 201809-69-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 201809-69-0, Name is 6-Bromobenzofuran-3(2H)-one,introducing its new discovery.

The invention relates to 3-substituted-1H-indole, 3-substituted-1H-pyrrolo[2,3-b]pyridine, and 3-substituted-1H-pyrrolo[3,2-b]pyridine compounds of the Formula (I): or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3572O – PubChem

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, SDS of cas: 201809-69-0, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 201809-69-0, Name is 6-Bromobenzofuran-3(2H)-one, molecular formula is C8H5BrO2

The first enantioselective formal [3 + 2] cycloaddition of aurone analogues with isocyanoacetates was developed via chiral Ag-complex catalysis. A variety of optically enriched spiro-1-pyrrolines were obtained in excellent yields, diastero- and enantioselectivities (up to 99% yield, >20:1 dr, >99% ee). This synthetic approach represents an extremely simple, efficient, and atom-economical method for spiro-1-pyrrolines synthesis.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3579O – PubChem

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201809-69-0, Name is 6-Bromobenzofuran-3(2H)-one, belongs to benzofurans compound, is a common compound. Application In Synthesis of 6-Bromobenzofuran-3(2H)-oneIn an article, once mentioned the new application about 201809-69-0.

The Amyloid beta protein binding specificity to [be] high, high permeability of the blood-brain barrier, brain senile plaques in storage properties, whereas, in the remaining portion except the old brain plaques characteristic hardly boron carrier compound. [Solving means] a flavone derivatives, chromone derivatives, coumarin derivatives, orlon derivatives, chalcone derivative, benzothiazole derivative in the stilbene derivative, beta-Amyloid-associated disease or pathological -10 boron atom in each derivative compounds for boron neutron capture therapy applications to Amyloid protein. [Drawing] no (by machine translation)

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3575O – PubChem

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NEW ARYL-BENZOCYCLOALKYL AMIDE DERIVATIVES

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 and n are as described herein, compositions including the compounds and methods of using the compounds.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3570O – PubChem

Top Picks: new discover of 6-Bromobenzofuran-3(2H)-one

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 201809-69-0, name is 6-Bromobenzofuran-3(2H)-one, introducing its new discovery. category: benzofuran

Transition-metal-free synthesis of polysubstituted pyrrole derivatives via cyclization of methyl isocyanoacetate with aurone analogues

Presented herein is an unprecedented transition-metal-free cyclization of methyl isocyanoacetate with aurone analogues catalyzed by NaOH. Various 2,3,4-trisubstituted pyrroles were obtained in excellent yields (up to 99%). The high efficiency of this synthetic procedure, coupled with the operational simplicity and atom economy, makes it an attractive method for the synthesis of polysubstituted pyrroles.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3578O – PubChem

Discovery of 6-Bromobenzofuran-3(2H)-one

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 201809-69-0. In my other articles, you can also check out more blogs about 201809-69-0

Application of 201809-69-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 201809-69-0, 6-Bromobenzofuran-3(2H)-one, introducing its new discovery.

DIHYDROBENZOFURAN AND INDEN ANALOGS AS CARDIAC SARCOMERE INHIBITORS

Provided are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein A, Z, B, R1, R2, R3, G1, G2, and G3 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt, thereof for use in methods of treatment heart diseases through cardiac sarcomere inhibtion.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3573O – PubChem

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201809-69-0, 6-Bromobenzofuran-3(2H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To FA (14.6 g, 318 mmol, 3.5 equiv) cooled to 0 oC was added TEA (27.5 g, 272 mmol, 3.0 equiv) dropwise with stirring under nitrogen. To this mixture were added a solution of 6-bromo-2,3-dihydro-1-benzofuran-3-one (19.4 g, 90.9 mmol, 1.0 equiv) in DCM (500 mL) and (S,S)-N-(p-toluenesulfonyl)-1-2-diphenylethanediamine(chloro)(p- cymene)ruthenium(II) (1.65 g, 2.6 mmol, 0.03 equiv). The mixture was stirred overnight at room temperature and poured into water (500 mL). The resulting solution was extracted with DCM (500 mL) three times. The combined organic layers were washed with brine (500 mL), dried over anhydrous sodium sulfate, concentrated under reduced pressure, and purified by silica gel chromatography (EA/PE, 1/9) to afford 13.4 g (69%) of (3R)-6-bromo-2,3-dihydro- 1-benzofuran-3-ol as a yellow solid with 96% ee. (Chiral_SFC, CHIRALPAK AD-H 4.6*100 mm, 5 mum)., 201809-69-0

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Reference£º
Patent; CYTOKINETICS, INC.; CHUANG, Chihyuan; MORGAN, Bradley P.; VANDERWAL, Mark; WANG, Wenyue; ASHCRAFT, Luke W.; (362 pag.)WO2019/144041; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem