With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.
5-(2-Bromoethyl)benzo[2,3-b]furan (17.2 g) was added to the mixture of 3-(S)- (+)-( 1 -carbamoyl- 1 , 1 -diphenylmethyl)pyrrolidine.L-(+)-tartrate (25 g), potassium hydroxide (11.4 g) in acetonitrile solvent at 25-35¡ã C. Reaction mass was heated to 40- 45¡ã C and maintained up to completion of the reaction . The reaction mass was then cooled to R.T and extracted with dichloromethane, the solvent distilled off under vacuum to give residue. Acetone was added to the residue and cooled to 10-15¡ã C. Hydrobromic acid was added to the above solution and heated to 20-25¡ã C and maintained for 10-12 hours. The reaction mass is filtered to give darifenacin hydrobromide., 127264-14-6
The synthetic route of 127264-14-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MATRIX LABORATOIRES LIMITED; WO2009/125430; (2009); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem