Category: 81742-10-1

81742-10-1, 3,6-Dichlorotrimellitic Anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Dibenzofuran-1,3-diol (prepared according to Carvalho, C. F. et al. (Supra)) (200 mg, 1 mmol), 2-fluoronaphthalene-1,3-diol 34 (178 mg, 1 mmol, AB part number 361828) and anhydrous 2,5-dichlorotrimellitic acid (260 mg, 1 mmol, AB part number 361892) were mixed in methanesulfonic acid (10 mL). Then, the mixture was stirred at 130 to 135 C. for 2 hours. The reaction mixture was cooled and mixed with ice water (100 mL). The precipitated dye was extracted with ethyl acetate (100 mL). The organic layer was washed with water (50 mL ¡Á 2) and washed with brine (50 mL ¡Á 1). After drying over sodium sulfate, the mixture was filtered, the solvent was removed, and the crude pigment was obtained as an isomeric mixture. These isomers were separated by thin layer chromatographic separation and 80 mg (13%) of a dye was obtained., 81742-10-1

As the paragraph descriping shows that 81742-10-1 is playing an increasingly important role.

Reference£º
Patent; APPLIED BIOSYSTEMS Ltd. LIABILITY COMPANY; BENSON, SCOTT CONRAD; MENCHEN, STEVEN MICHAEL; THEISEN, PETER DAVID; UPADHYA, KRISHNA GAJANAN; HAUSER, JOAN DALE; (37 pag.)JP2015/57478; (2015); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81742-10-1,3,6-Dichlorotrimellitic Anhydride,as a common compound, the synthetic route is as follows.,81742-10-1

General procedure: A mixture of compound 14 (1 g, 6.7 mmol) and 3,6-dichlorotrimellitic anhydride (875 mg, 3.35 mmol) in 5 mL polyphosphoric acid is heated to 180 C. overnight. After cooling to room temperature, the mixture is poured into ice/water, and stirred for 30 min. The resulting precipitate is filtered, washed with water, and dried under vacuum. The crude product is purified on silica gel using CH2Cl2/MeOH. Yield: 438 mg (25%).

81742-10-1 3,6-Dichlorotrimellitic Anhydride 15883776, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Ying, Laiqiang; (22 pag.)US10513610; (2019); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81742-10-1,3,6-Dichlorotrimellitic Anhydride,as a common compound, the synthetic route is as follows.,81742-10-1

General procedure: The synthetic steps of MPc (COOH) 4Cl8 (Scheme 1). A mixture of1.0025 g of 3,6-dichloro-1,2,4-benzenetricarboxylic anhydride,6.0000 g of urea, 0.3654 g of Mn(CH3COOH)2¡¤4H2O, 0.25 g of NH4Cland 0.1200 g of (NH4)2Mo2O7 in 100 mL three-necked flask was heatedat 140 C for 0.5 h with magnetic stirrer and reflux condenser, and thenkept at 220 C for 6 h under ambient air conditions. The by-productswere washed with water followed by 6 mol L-1 hydrochloric acid forseveral times. Then the purification of blue solid was achieved by refluxingwith 150 mL of acetone and trichloromethane about 12 h.The obtained octachloro-tetracarboxamide phthalocyanine was hydrolyzedwith 100 mL of 2.0 mol¡¤L-1 sodium hydroxide solution at 100 C for 12 h, filtered, and the filtrate was adjusted to pH=1 withhydrochloric acid, a large amount of precipitates were produced andfiltered by the G4 sand core funnel, the filter cake was washed first withdeionized water until the filtrate was neutral. Then the filter cake waswashed with in proper order. The solid product was vacuum dried at100 C. The as-prepared MPcTcCl8 were washed by chloroform,ethanol, ether, acetone and THF respectively, dried in vacuum overnightat 100 C.

81742-10-1 3,6-Dichlorotrimellitic Anhydride 15883776, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Gao, Min; Zhang, Gai; Tian, Min; Liu, Bulei; Chen, Weixing; Inorganica Chimica Acta; vol. 485; (2019); p. 58 – 63;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

81742-10-1, 3,6-Dichlorotrimellitic Anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

81742-10-1, 4-(naphth-2-yl)-2-fluoro-1,3-dihydroxybenzene 14 (760 mg, 2.988 mmol) obtained from Example 3, anhydrous 2,5-dichlorotrimellitic acid 23 (780 mg, 2.988 mmol, PE Applied Biosystems, Foster City, CA (AB) Part No. 361892), nitrobenzene (5 mL), and aluminum chloride in nitrobenzene (15 mL, 1 M, Aldrich Chemical) were mixed and the mixture was stirred at room temperature for 16 hours. The reaction mixture was added to ice water (100 mL) and was poured into a magnetically stirred mixture of ethyl acetate (100 mL), 10% HCl (100 mL) was added, and aluminum salt was dissolved. The organic layer was washed with water (100 mL ¡Á 2) and washed with brine (100 mL ¡Á 1), dried over sodium sulfate, filtered, and the solvent was removed. The product was obtained as an isomeric mixture. The product was purified by silica gel column chromatography (silica gel,10% methanol in dichloromethane mobile phase) to obtain the desired slow moving isomer 340 mg (22%) .

The synthetic route of 81742-10-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; APPLIED BIOSYSTEMS Ltd. LIABILITY COMPANY; BENSON, SCOTT CONRAD; MENCHEN, STEVEN MICHAEL; THEISEN, PETER DAVID; UPADHYA, KRISHNA GAJANAN; HAUSER, JOAN DALE; (37 pag.)JP2015/57478; (2015); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

81742-10-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81742-10-1,3,6-Dichlorotrimellitic Anhydride,as a common compound, the synthetic route is as follows.

4-(naphth-2-yl)-2-fluoro-1,3-dihydroxybenzene 14 (100 mg, 0.4 mmol) obtained from Example 3, anhydrous 2,5-dichlorotrimellitic acid 23 (52 mg, 0.2 mmol, AB part 361892), and methanesulfonic acid (5 mL) at 120-130C, and the mixture was stirred for 2 hours. Then,the mixture was mixed with ice water (50 mL), cooled and precipitate was formed. The precipitated dye was extracted with ethyl acetate (100 mL), the extract was washed with water (50 mL ¡Á 2) and washed with brine (50 mL ¡Á 1). The resulting mixture was dried over sodium sulfate, filtered, and solvent was removed and the crude pigment was obtained as two isomers. The obtained isomers can be separated by thin-layer chromatography (silica gel,Mobile phase of dichloromethane: methanol: acetic acid 100: 10: 2 (by volume)), and 60 mg (41%) of the desired slowly moving isomer was obtained.

81742-10-1 3,6-Dichlorotrimellitic Anhydride 15883776, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; APPLIED BIOSYSTEMS Ltd. LIABILITY COMPANY; BENSON, SCOTT CONRAD; MENCHEN, STEVEN MICHAEL; THEISEN, PETER DAVID; UPADHYA, KRISHNA GAJANAN; HAUSER, JOAN DALE; (37 pag.)JP2015/57478; (2015); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81742-10-1,3,6-Dichlorotrimellitic Anhydride,as a common compound, the synthetic route is as follows.,81742-10-1

General procedure: The synthetic steps of MPc (COOH) 4Cl8 (Scheme 1). A mixture of1.0025 g of 3,6-dichloro-1,2,4-benzenetricarboxylic anhydride,6.0000 g of urea, 0.3654 g of Mn(CH3COOH)2¡¤4H2O, 0.25 g of NH4Cland 0.1200 g of (NH4)2Mo2O7 in 100 mL three-necked flask was heatedat 140 C for 0.5 h with magnetic stirrer and reflux condenser, and thenkept at 220 C for 6 h under ambient air conditions. The by-productswere washed with water followed by 6 mol L-1 hydrochloric acid forseveral times. Then the purification of blue solid was achieved by refluxingwith 150 mL of acetone and trichloromethane about 12 h.The obtained octachloro-tetracarboxamide phthalocyanine was hydrolyzedwith 100 mL of 2.0 mol¡¤L-1 sodium hydroxide solution at 100 C for 12 h, filtered, and the filtrate was adjusted to pH=1 withhydrochloric acid, a large amount of precipitates were produced andfiltered by the G4 sand core funnel, the filter cake was washed first withdeionized water until the filtrate was neutral. Then the filter cake waswashed with in proper order. The solid product was vacuum dried at100 C. The as-prepared MPcTcCl8 were washed by chloroform,ethanol, ether, acetone and THF respectively, dried in vacuum overnightat 100 C.

The synthetic route of 81742-10-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gao, Min; Zhang, Gai; Tian, Min; Liu, Bulei; Chen, Weixing; Inorganica Chimica Acta; vol. 485; (2019); p. 58 – 63;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

81742-10-1, 3,6-Dichlorotrimellitic Anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

81742-10-1, General procedure: Place 5 mL concentrated H2SO4 in a 50 mL round bottom flask and cool in an ice/water bath. Compound 20 (300 mg, 0.5 mmol) is added in portions, and the reaction mixture is stirred at room temperature until TLC shows complete consumption of compound 20. The mixture is added to the stirring Et2O solution (400 mL) at 0 C. The resulting precipitate is filtered, washed with EtOAc, and dried. The crude product is purified by RP-HPLC using TEAA/ACN give compound 5a (96 mg, 20%) and compound 5b (101 mg, 21%).

The synthetic route of 81742-10-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ying, Laiqiang; (22 pag.)US10513610; (2019); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem