With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81742-10-1,3,6-Dichlorotrimellitic Anhydride,as a common compound, the synthetic route is as follows.,81742-10-1
General procedure: The synthetic steps of MPc (COOH) 4Cl8 (Scheme 1). A mixture of1.0025 g of 3,6-dichloro-1,2,4-benzenetricarboxylic anhydride,6.0000 g of urea, 0.3654 g of Mn(CH3COOH)2¡¤4H2O, 0.25 g of NH4Cland 0.1200 g of (NH4)2Mo2O7 in 100 mL three-necked flask was heatedat 140 C for 0.5 h with magnetic stirrer and reflux condenser, and thenkept at 220 C for 6 h under ambient air conditions. The by-productswere washed with water followed by 6 mol L-1 hydrochloric acid forseveral times. Then the purification of blue solid was achieved by refluxingwith 150 mL of acetone and trichloromethane about 12 h.The obtained octachloro-tetracarboxamide phthalocyanine was hydrolyzedwith 100 mL of 2.0 mol¡¤L-1 sodium hydroxide solution at 100 C for 12 h, filtered, and the filtrate was adjusted to pH=1 withhydrochloric acid, a large amount of precipitates were produced andfiltered by the G4 sand core funnel, the filter cake was washed first withdeionized water until the filtrate was neutral. Then the filter cake waswashed with in proper order. The solid product was vacuum dried at100 C. The as-prepared MPcTcCl8 were washed by chloroform,ethanol, ether, acetone and THF respectively, dried in vacuum overnightat 100 C.
The synthetic route of 81742-10-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Gao, Min; Zhang, Gai; Tian, Min; Liu, Bulei; Chen, Weixing; Inorganica Chimica Acta; vol. 485; (2019); p. 58 – 63;,
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