Downstream synthetic route of 69604-00-8

The synthetic route of 69604-00-8 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69604-00-8,Ethyl 5-nitrobenzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.

69604-00-8, Step A: Preparation of ethyl-5-amino-1-benzofuran-2-carboxylateEthyl-5-nitro-1-benzofuran-2-carboxylate (100 g) was added to methanol (500mL). 2.5% (w/w) Palladiumlcarbon (10 g in 10 mL water) was added to the hydrogenator.The hydrogen gas was passed at a pressure of 1 to 4 kg/cm2 for 2 hours to 4 hours at 25C to 50C. The reaction mixture was filtered through a Celite filter. The solvent was recovered under vacuum. A mixture of de-ionized water (500 mL) and dichloromethane (300 mL) was added to the reaction mixture and the layers obtained were separated. Theorganic layer was recovered under vacuum to obtain the title compound.Yield (Wet): 82 g

The synthetic route of 69604-00-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RANBAXY LABORATORIES LIMITED; DAS, Prasenjit; SRIVASTAVA, Bindu; JOSEPH, Sony; MAHESHWARI, Nitin; PRASAD, Mohan; ARORA, Sudershan, Kumar; WO2014/61000; (2014); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem