Synthesis and antilipolytic activities of quinolyl carbanilates and related analogs was written by Musser, John H.;Chakraborty, Utpal;Bailey, Kevin;Sciortino, Stan;Whyzmuzis, Carol;Amin, Dilip;Sutherland, Charles A.. And the article was included in Journal of Medicinal Chemistry in 1987.COA of Formula: C10H8O4 This article mentions the following:
A series of quinolyl carbanilates (e.g., I and II) was prepared and tested as antilipolytic agents. These compounds inhibited production of glycerol from rat adipocytes and inhibited liberation of free fatty acids from triolein by canine cardiac triglyceride lipases. An extensive structure-activity relationship study indicated that 8-quinolyl 4-methoxycarbanilate (I) contained features necessary for maximum potency in vitro. Substituting a benzofuranyl group for the quinolyl group of I provided the most interesting compound on the basis of both potency and structural novelty. 7-Benzofuranyl 4-methoxycarbanilate (III) has IC50‘s of 16 and 0.3 μM in the myocardial lipase and rat adipocyte assays, resp. In vivo, III was orally active as an inhibitor (97% at 25 mg/kg) of lipolysis in the rat. In the experiment, the researchers used many compounds, for example, 7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8COA of Formula: C10H8O4).
7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.COA of Formula: C10H8O4
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem