The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Methyl 4-bromo-2-formylbenzoate( cas:1260795-42-3 ) is researched.Synthetic Route of C9H7BrO3.Ray, Sumit K.; Sadhu, Milon M.; Biswas, Rayhan G.; Unhale, Rajshekhar A.; Singh, Vinod K. published the article 《A General Catalytic Route to Enantioenriched Isoindolinones and Phthalides: Application in the Synthesis of (S)-PD 172938》 about this compound( cas:1260795-42-3 ) in Organic Letters. Keywords: chiral Bronsted acid catalyst tandem Mannich lactamization diazoester; isoindolinone phthalide asym preparation. Let’s learn more about this compound (cas:1260795-42-3).
Chiral Bronsted acid catalyzed enantioselective syntheses of isoindolinones, e.g. I, and phthalides have been accomplished via tandem Mannich-lactamization and aldol-lactonization reactions, resp. A variety of enantioenriched isoindolinones (up to 99% ee) and phthalides (up to 85% ee) containing α-diazoesters were afforded in excellent yields. Furthermore, a concise synthesis of (S)-PD 172938 has been demonstrated by using this protocol.
The article 《A General Catalytic Route to Enantioenriched Isoindolinones and Phthalides: Application in the Synthesis of (S)-PD 172938》 also mentions many details about this compound(1260795-42-3)Synthetic Route of C9H7BrO3, you can pay attention to it, because details determine success or failure