Synthesis of fused furans by gas-phase pyrolysis of 2-allyloxyaryl-propenoic esters was written by Black, Michael;Cadogan, J. I. G.;Mcnab, Hamish;Macpherson, Andrew D.;Roddam, V. Peter;Smith, Carol;Swenson, Helen R.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry in 1997.Recommanded Product: Methyl benzofuran-2-carboxylate This article mentions the following:
Flash vacuum pyrolysis of 2-allyloxypropenoic esters, e.g., I, gives benzo[b]furans, e.g., II, in synthetically useful yields by sequential generation of a phenoxyl radical, cyclization and ejection of the carboxylic ester function as a free radical leaving group. The method is compatible with a range of substituents on either the benzene ring or the propenoate chain, and is particularly effective for 2-substituted benzo[b]furans. The natural products 5-methoxybenzo[b]furan and angelicin have been synthesized in three and four steps resp. from com. available starting materials by this route. Related cyclizations to give naphtho[2,1-b]furan III were complicated by competitive formation of naphtho-[2,1b]pyran-3-ones, but the yield of the required product could be optimized by the choice of the radical precursor. Annulation of a furan ring onto a thiophene is also possible by this method, but lower yields are obtained in such pyrolyzes. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Recommanded Product: Methyl benzofuran-2-carboxylate).
Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Recommanded Product: Methyl benzofuran-2-carboxylate
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem