Omar, Mahmoud A. et al. published their research in Microchemical Journal in 2019 | CAS: 38183-12-9

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C17H10O4

Diarylpyrrolone based fluorophore for the selective spectrofluorometric method for determination of Linagliptin antidiabetic drug in pharmaceutical tablets was written by Omar, Mahmoud A.;Haredy, Ahmed M.;Saleh, Gamal A.;Naggar, A. H.;Derayea, Sayed M.. And the article was included in Microchemical Journal in 2019.Formula: C17H10O4 This article mentions the following:

Linagliptin (LNG) is a type 2 antidiabetic drug which belongs to dipeptidyl peptidase 4 inhibitors. In this paper a simple and sensitive spectrofluorometric method was developed and validated for the determination of LNG. The method employed the interaction of the primary amino group of the cited drug with fluorescamine reagent in aqueous borate buffer (pH 8.5) to produce a highly fluorescent product. The emission of the formed product was measured at 479 nm after excitation at 390 nm. Different exptl. parameters that may affect the product formation or its fluorescence intensity were investigated and adjusted. The method has a good linearity in the concentration range of 0.2 – 2.0 μg mL-1of LNG with a detection limit of 0.079 μg mL-1. The performance of the developed method was evaluated according to the International Conference for Harmonization (ICH). The method was successfully applied for the anal. of tablets dosage form that contained the cited drug. The results of the anal. were compared with the reported method and indicated good accuracy and precision of the proposed procedure. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem