Some scientific research about Isobenzofuran-1(3H)-one

Safety of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Limban, C; Chifiriuc, MC; Caproiu, MT; Dumitrascu, F; Ferbinteanu, M; Pintilie, L; Stefaniu, A; Vlad, IM; Bleotu, C; Marutescu, LG; Nuta, DC or send Email.

Safety of Isobenzofuran-1(3H)-one. In 2020 MOLECULES published article about THIOUREA DERIVATIVES; ANTIFUNGAL ACTIVITY; CRYSTAL; ACID; TRIFLUOROMETHYLATION; ANTIMALARIAL; DISCOVERY; HIV in [Limban, Carmen; Vlad, Ilinca Margareta; Nuta, Diana Camelia] Carol Davila Univ Med & Pharm, Dept Pharmaceut Chem, Bucharest 020956, Romania; [Chifiriuc, Mariana Carmen; Marutescu, Luminita Gabriela] Univ Bucharest, Fac Biol, Dept Microbiol, ICUB, Bucharest 060101, Romania; [Chifiriuc, Mariana Carmen; Marutescu, Luminita Gabriela] Univ Bucharest, Res Inst, ICUB, Bucharest 060101, Romania; [Caproiu, Miron Teodor; Dumitrascu, Florea] Romanian Acad CD Nenitescu, Organ Chem Ctr, Bucharest 060023, Romania; [Ferbinteanu, Marilena] Univ Bucharest, Fac Chem, Inorgan Chem Dept, Bucharest 020462, Romania; [Pintilie, Lucia; Stefaniu, Amalia] Natl Inst Chem Pharmaceut Res & Dev, Bucharest 031299, Romania; [Bleotu, Coralia] Stefan S Nicolau Inst Virol, Mihai Bravu 285, Bucharest 030304, Romania in 2020, Cited 64. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

The increasing threat of antimicrobial resistance to all currently available therapeutic agents has urged the development of novel antimicrobials. In this context, a series of new benzoylthiourea derivatives substituted with one or more fluorine atoms and with the trifluoromethyl group have been tested, synthesized, and characterized by IR, NMR, CHNS and crystal X-ray diffraction. The molecular docking has provided information regarding the binding affinity and the orientation of the new compounds to Escherichia coli DNA gyrase B. The docking score predicted the antimicrobial activity of the studied compounds, especially against E. coli, which was further demonstrated experimentally against planktonic and biofilm embedded bacterial and fungal cells. The compounds bearing one fluorine atom on the phenyl ring have shown the best antibacterial effect, while those with three fluorine atoms exhibited the most intensive antifungal activity. All tested compounds exhibited antibiofilm activity, correlated with the trifluoromethyl substituent, most favorable in para position.

Safety of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Limban, C; Chifiriuc, MC; Caproiu, MT; Dumitrascu, F; Ferbinteanu, M; Pintilie, L; Stefaniu, A; Vlad, IM; Bleotu, C; Marutescu, LG; Nuta, DC or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem