Synthesis of some biologically active 2&2,2-disubstituted 1,2,3,4-tetrahydro-4-thiobenzofuro[3,2-d]pyrimidines and their reactions was written by Basavaraja, K. M.;Patil, V. M.;Agasimundin, Y. S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2007.SDS of cas: 54802-10-7 This article mentions the following:
The condensation of 3-amino-2-carboxamide (I) with various aldehydes in the presence of hydrochloric acid gave the corresponding 2-aryl-1,2,3,4-tetrahydro-4-oxobenzofuro[3,2-d]pyrimidines II (X = O; R1 = H; R2 = Ph, 4-NO2C6H4, 4-MeOC6H4, furyl). Compound I was converted into the required intermediate thiocarboxamide by the reaction with phosphorus pentasulfide in anhyd pyridine. The acid-catalyzed condensation of the thiocarboxamide with various ketones afforded the anticipated 2,2-dialkyl-1,2,3,4-tetrahydro-4-thiobenzofuro[3,2-d]pyrimidines II (X = S; R1 = R2 = Me; R1 = Me, R2 = Et; R1 = R2 = Et; R1 = Me, R2 = iBu), and with various aromatic aldehydes under similar conditions furnished the resp. 2-aryl-1,2,3,4-tetrahydro-4-thiobenzofuro[3,2-d]pyrimidines II (X = S; R1 = H; R2 = Ph, 4-NO2C6H4, 4-MeOC6H4, furyl) in good yields. The methylation of the tetrahydrothiobenzofuro[3,2-d]pyrimidines led to the formation of a product which was found to be identical with 3-aminobenzofuran-2-carbonitrile, which has already been prepared in this laboratory Compounds II (X = S; R1 = R2 = Me; R1 = Me, R2 = Et; R1 = R2 = Et; R1 = Me, R2 = iBu; R1 = H, R2 = 4-OMeC6H4) underwent displacement by morpholine or piperidine to produce the resp. derivatives III (X = CH2 or O). The synthesis of 1,2,3,4-tetrahydro-2-oxo-4-thiobenzofuro[3,2-d]pyrimidine (IV) and displacement of the mercapto group to produce the corresponding cyclic amine-substituted compounds was also investigated. The structures of all the compounds were well supported by spectral and anal. data. Some of the compounds exhibited moderate to appreciable antibacterial activity against S. aureus and E. coli. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7SDS of cas: 54802-10-7).
3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.SDS of cas: 54802-10-7
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem