Category: 54802-10-7

Synthesis and biological activities of pyrazolinobenzofuro[3,2-d]pyridimidines was written by Basawaraj, Raga;Goled, S. N.;Khandre, Omakar;Sangapure, S. S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2011.Name: 3-Aminobenzofuran-2-carboxamide This article mentions the following:

2-(2,4,6-Trimethoxyphenyl/α-naphthyl)-4-hydrazinobenzofuro[3,2-d]pyrimidines 5,6 were prepared by nucleophilic substitution of 2-(trimethoxyphenyl/α-naphthyl)-4-chlorobenzofuro[3,2-d]pyrimidines 3,4 with N₂H₄.H₂O in MeOH. The reaction of 2-substituted 4-hydrazinobenzofuro[3,2-d]pyrimidines 5,6 with Ac₂CH₂, NCCH₂CO₂Et, or AcCH₂CO₂Et in NaOEt furnished pyrazolyl- and pyrazolinylbenzofuro[3,2-d]pyrimidines. These compounds exhibited antimicrobial and anti-inflammatory activity. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Name: 3-Aminobenzofuran-2-carboxamide).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Name: 3-Aminobenzofuran-2-carboxamide

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis of some biologically active 2&2,2-disubstituted 1,2,3,4-tetrahydro-4-thiobenzofuro[3,2-d]pyrimidines and their reactions was written by Basavaraja, K. M.;Patil, V. M.;Agasimundin, Y. S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2007.SDS of cas: 54802-10-7 This article mentions the following:

The condensation of 3-amino-2-carboxamide (I) with various aldehydes in the presence of hydrochloric acid gave the corresponding 2-aryl-1,2,3,4-tetrahydro-4-oxobenzofuro[3,2-d]pyrimidines II (X = O; R¹ = H; R² = Ph, 4-NO₂C₆H₄, 4-MeOC₆H₄, furyl). Compound I was converted into the required intermediate thiocarboxamide by the reaction with phosphorus pentasulfide in anhyd pyridine. The acid-catalyzed condensation of the thiocarboxamide with various ketones afforded the anticipated 2,2-dialkyl-1,2,3,4-tetrahydro-4-thiobenzofuro[3,2-d]pyrimidines II (X = S; R¹ = R² = Me; R¹ = Me, R² = Et; R¹ = R² = Et; R¹ = Me, R² = iBu), and with various aromatic aldehydes under similar conditions furnished the resp. 2-aryl-1,2,3,4-tetrahydro-4-thiobenzofuro[3,2-d]pyrimidines II (X = S; R¹ = H; R² = Ph, 4-NO₂C₆H₄, 4-MeOC₆H₄, furyl) in good yields. The methylation of the tetrahydrothiobenzofuro[3,2-d]pyrimidines led to the formation of a product which was found to be identical with 3-aminobenzofuran-2-carbonitrile, which has already been prepared in this laboratory Compounds II (X = S; R¹ = R² = Me; R¹ = Me, R² = Et; R¹ = R² = Et; R¹ = Me, R² = iBu; R¹ = H, R² = 4-OMeC₆H₄) underwent displacement by morpholine or piperidine to produce the resp. derivatives III (X = CH₂ or O). The synthesis of 1,2,3,4-tetrahydro-2-oxo-4-thiobenzofuro[3,2-d]pyrimidine (IV) and displacement of the mercapto group to produce the corresponding cyclic amine-substituted compounds was also investigated. The structures of all the compounds were well supported by spectral and anal. data. Some of the compounds exhibited moderate to appreciable antibacterial activity against S. aureus and E. coli. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7SDS of cas: 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.SDS of cas: 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and biological evaluation of benzofuro[3,2-d]pyrimidines was written by Basawaraj, Raga;Shashikanth, Goled;Hugar, M. H.;Sangapure, S. S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2009.Related Products of 54802-10-7 This article mentions the following:

The reaction of 3-amino-2-benzofurancarboxamide with 3,4,5-trimethoxybenzaldehyde in presence of catalytic quantity of conc hydrochloric acid gave 2-aryl-3,4-dihydro-4-oxo-benzofuran[3,2-d]pyrimidine (I). The nucleophilic displacement reaction of the compound I with phosphorus oxychloride furnished 2-(3,4,5-trimethoxyphenyl)-3,4-dihydro-4-chlorobenzofuro[3,2-d]pyrimidine (II). Some 2,4-disubstituted benzofuran[3,2-d]pyrimidine derivatives were prepared by the reaction of compound II with different reagents. All the synthesized compounds were characterized on the basis of IR, ¹H NMR, mass spectra and anal. data. The compounds synthesized were screened for antibacterial and antifungal activities. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Related Products of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Related Products of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Detection of Zinc(II) by a Fluorescence Chemosensor Based on Benzofuran in Aqueous Media and Live Cells was written by Jang, Hyo Jung;Kim, Ahran;Jung, Jae Min;Lee, Misun;Lim, Mi Hee;Kim, Cheal. And the article was included in Bulletin of the Korean Chemical Society in 2018.Related Products of 54802-10-7 This article mentions the following:

A fluorescence chemosensor HBC ((E)-3-((2-hydroxybenzylidene)amino)benzofuran-2-carboxamide) for detection of Zn²⁺ was designed by the condensation combination of 3-aminobenzofuran-2-carboxamide and salicylaldehyde. Sensor HBC showed an excellent selective “off-on” fluorescent response toward Zn²⁺. Detection limit (1.08μM) for Zn²⁺ was much lower than the WHO standard (76.0μM). Importantly, HBC could recognize and quantify Zn²⁺ in real samples and live cells. Detection process of HBC for Zn²⁺ was explained by ESI-mass, Job plot, UV-Vis and ¹H NMR titrations, and theor. calculations In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Related Products of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Related Products of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Highly selective and sensitive ‘on-off’ fluorescent chemosensor for Fe³⁺ ions crafted by benzofuran moiety in both experimental and theoretical methods was written by Madhu, P.;Sivakumar, P.;Sribalan, Rajendran;Arumugam, Senthil M.. And the article was included in Luminescence in 2022.Category: benzofurans This article mentions the following:

A benzofuran glycinamide-based chemosensor, 3-(2-([4-fluorobenzyl]amino)acetamido)benzofuran-2-carboxamide (BGA) was developed and synthesized for the selective and sensitive detection of Fe³⁺ ions. The photophys. properties of the probe BGA were studied using UV-visible light absorption and fluorescence spectrophotometers. The chemosensor BGA showed a marked ‘on-off’ fluorescence response toward Fe³⁺ ions in the presence of other metal ions in DMSO/H₂O solution (9/1, volume/volume). The very low limits of detection (LOD) were calculated to be 10 nM and 43 nM using UV-visible light absorption and fluorescence spectrophotometers, resp. Job’s plot anal. revealed the formation of a BGA-Fe³⁺ complex with a 1:1 binding stoichiometry ratio using UV-visible light spectroscopy. The sensing mechanism was also demonstrated using d. functional theory calculation In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Category: benzofurans).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The design, synthesis, and biological evaluation of PIM kinase inhibitors was written by Tsuhako, Amy Lew;Brown, David S.;Koltun, Elena S.;Aay, Naing;Arcalas, Arlyn;Chan, Vicky;Du, Hongwang;Engst, Stefan;Franzini, Maurizio;Galan, Adam;Huang, Ping;Johnston, Stuart;Kane, Brian;Kim, Moon H.;Douglas Laird, A.;Lin, Rui;Mock, Lillian;Ngan, Iris;Pack, Michael;Stott, Gordon;Stout, Thomas J.;Yu, Peiwen;Zaharia, Cristiana;Zhang, Wentao;Zhou, Peiwen;Nuss, John M.;Kearney, Patrick C.;Xu, Wei. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Product Details of 54802-10-7 This article mentions the following:

A series of substituted benzofuropyrimidinones with pan-PIM activities and excellent selectivity against a panel of diverse kinases is described. Initial exploration identified aryl benzofuropyrimidinones that were potent, but had cell permeability limitations. Using X-ray crystal structures of the bound PIM-1 complexes with I, II, and III, the authors were able to guide the SAR and identify alkyl benzofuropyrimidinone IV with good PIM potencies, permeability, and oral exposure. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Product Details of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Product Details of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Studies on benzofurans. Part IV: Synthesis of some 2-substituted and 2,3-disubstituted 3,4-dihydro-4-oxobenzofuro[3,2-d]pyrimidines was written by Mahajan, S. B.;Agasimundin, Y. S.. And the article was included in Journal of the Indian Chemical Society in 1977.Related Products of 54802-10-7 This article mentions the following:

The acylaminofurancarboxylic acids I (R = Me, Et, Ph, PhCH₂) were cyclized to give the benzofurooxazines II, which were treated with amines to give the benzofuropyrimidines III (R = Me, Et, PhCH₂, R¹ = H; R = Me, R¹ = Ph, substituted Ph, 2-naphthyl). In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Related Products of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Related Products of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Design, synthesis and antiproliferative activity against human cancer cell lines of novel benzo-, benzofuro-, azolo- and thieno-1,3-thiazinone resorcinol hybrids was written by Matysiak, Joanna;Karpinska, Monika M.;Skrzypek, Alicja;Wietrzyk, Joanna;Klopotowska, Dagmara;Niewiadomy, Andrzej;Paw, Beata;Juszczak, Malgorzata;Rzeski, Wojciech. And the article was included in Arabian Journal of Chemistry in 2019.Product Details of 54802-10-7 This article mentions the following:

The design and synthesis of novel derivatives of the 4H-3,1-benzothiazinone type and heterocyclic analogs, i.e. benzofuro-, azolo- and thieno-1,3-thiazin-4-ones possessing 2,4-dihydroxyphenyl substituent is reported. The compounds were obtained by the one-step reaction of aminobenzamides or heterocyclic aminocarboxamides with aryl-modified sulfinylbis[(2,4-dihydroxyphenyl)methanethione]. Evaluation of their antiproliferative potency against human cancer cell lines showed that the activity of some analogs was similar to that of cisplatin. The highest activity and low toxicity were found for 6-tert-butyl-2-(5-chloro-2,4-dihydroxyphenyl)-4H-thieno[3,2-d][1,3]thiazin-4-one. The structure-activity elucidation reveals that the most active compounds are those with a thienothiazin-4-one and benzofuro[3,2-d][1,3]thiazin-4-one skeleton and the presence of the hydrophobic substituent (Et, Cl) in the benzenediol moiety increases their antiproliferative potency. The ADMET properties of selected compounds including metabolic stability and toxicity profile were estimated in silico. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Product Details of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Product Details of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and nucleophilic displacement reactions of biologically active 2,4-dichlorobenzofuro[3,2-d]pyrimidines was written by Basavaraja, K. M.;Patil, V. M.;Agasimundin, Y. S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2006.Name: 3-Aminobenzofuran-2-carboxamide This article mentions the following:

1,2,3,4-Tetrahydro-2,4-dioxobenzofuro[3,2-d]pyrimidine was converted into 2,4-dichlorobenzofuro[3,2-d]pyrimidine (I) by treatment with phosphorus pentachloride. The dichloro compound I was subjected to nucleophilic displacement reactions with nucleophiles such as, alkoxides, amines, azides and hydrazine. The hydrazine compounds were converted into tetracyclic benzofuro[3,2-d]pyrimidine fused with triazole. Similar tetracyclic heterocycle containing tetrazole ring system was prepared by the diazotization of compound 2-chloro-4-hydrazinobenzofuropyrimidine and also by the reaction of dichloro compound I with one equivalent of sodium azide. The reaction of I with two equivalent of sodium azide yielded pentacyclic heterocyclic with two fused tetrazole ring system, bistetazolobenzofuropyrimidine. All the compounds thus prepared were screened for antibacterial activity against Gram pos. and Gram neg. organisms. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Name: 3-Aminobenzofuran-2-carboxamide).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Name: 3-Aminobenzofuran-2-carboxamide

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Evaluation of the effect of 2-(2,4-dihydroxyphenyl)-4H-benzofuro[3,2-d][1,3]thiazin-4-one on colon cells and its anticancer potential was written by Czerwonka, Arkadiusz;Lemieszek, Marta K.;Karpinska, Monika;Matysiak, Joanna;Niewiadomy, Andrzej;Rzeski, Wojciech. And the article was included in Medicinal Chemistry Research in 2018.Reference of 54802-10-7 This article mentions the following:

In this paper, we present the biol. effect of the newly synthesized 2-(2,4-dihydroxyphenyl)-4H-benzofuro[3,2-d][1,3]thiazin-4-one (DPBT) on human colon adenocarcinoma cell lines (HT-29 and LS180). Addnl., DPBT cytotoxicity was examined in human colon epithelial cells (CCD 841 CoTr) and human skin fibroblasts (HSF). The studies revealed a significant decrease in the proliferation of cancer cells after exposure to DPBT at concentrations in the range of 10-100 μM. Addnl., DPBT was not toxic to normal CCD 841 CoTr and HSF cells at concentrations that induced inhibition of cancer cell proliferation. The nature of the anti-proliferative action of DPBT in the cell cycle progression in colon cancer cells and the expression of proteins involved in this process were examined by flow cytometry and western blotting, resp. The investigations demonstrated higher sensitivity of LS180 than HT-29 to the DPBT treatment. The anti-proliferative action of DPBT in LS180 was attributed to cell cycle arrest in the G₁ phase via up-regulation of p27^KIP1 and down-regulation of cyclin D1 and CDK4 proteins. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Reference of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Reference of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem