Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Pharmacology of antiinflammatory imidazoles. Author is Winter, R..
Of 67 imidazole derivatives tested for antinflammatory activity in rats, 2,5-dimethyl-4-phenylimidazole-HCl (I) [40405-82-1] was the most active. Its antiedema and granulation inhibiting actions were greater than those of phenylbutazone sodium [129-18-0]. On further testing I potentiated hexobarbital narcosis in mice, had anticonvulsive activity in mice, and decreased the body temperature of rats. It did not have a central analgetic effect. The acute LD50 values for I were 71 mg/kg i.p. and 230 mg/kg orally in mice and 76.5 mg/kg s.c. in rats.
The article 《Pharmacology of antiinflammatory imidazoles》 also mentions many details about this compound(129-18-0)Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, you can pay attention to it, because details determine success or failure
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem