Discovery of 3-Methylbenzofuran-2-carboxylic acid

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The present invention provides a method for promoting plant growth, which comprises treating a plant with at least one compound represented by the following Formula (1) The compounds indicated by formula (1) are used to promote the growth of plants. A plant seed resulting from treating with the compound represented by formula (1) and comprising an effective quantity of the compound represented by formula (1). A composition for promoting plant growth comprising the compound represented by formula (1) and an inactive ingredient.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2700O – PubChem

New explortion of 24673-56-1

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Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase. Also described herein are methods of using such HDAC inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of HDAC activity

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2688O – PubChem

Discovery of 24673-56-1

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Modification of alpha-biphenylsulfonamidocarboxylic acids led to potent and selective MMP-13 inhibitors. Compound 16 showed 100% oral bioavailability in rats and demonstrated >50% inhibition of bovine cartilage degradation at 10 ng/mL.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2749O – PubChem

Brief introduction of 3-Methylbenzofuran-2-carboxylic acid

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This work demonstrates an alternative method to prepare allylated arenes and aryl-substituted allylic esters via catalytic decarboxylative C-C bond formation using aromatic carboxylic acids and allylic halides and esters.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2782O – PubChem

New explortion of 24673-56-1

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Computed Properties of C10H8O3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 24673-56-1, Name is 3-Methylbenzofuran-2-carboxylic acid, molecular formula is C10H8O3

The invention provides a method of synthesizing aromatic dichloro methyl ester. The method from the solution proceeding aryl carboxylic acid, alkali as additive, with the dichloromethane in the air condition efficiently synthesizing aromatic abnormal growth ester compound. With the conventional ester compound compared with the synthesis method, the method of this invention has raw materials of reaction (aryl carboxylic acid and dichloromethane) is cheap, simple reaction conditions, to a plurality of functional groups on the aromatic ring has good tolerant, high productivity of the obvious advantage. The method of the invention can be widely applied to the pharmaceutical industry and academia, material, such as natural product in the synthesis of the field. (by machine translation)

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2687O – PubChem

Some scientific research about 3-Methylbenzofuran-2-carboxylic acid

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Herein, compounds, compositions and methods for modulating inclusion formation and stress granules in cells related to the onset of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmological diseases, and viral infections are described.

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Reference:
Benzofuran – Wikipedia,
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Extended knowledge of 24673-56-1

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Aryl-substituted five-membered heteroaromatics have attracted great interest over the past years due to their presence in a large number of pharmaceuticals and natural products. Recently, an advance in the preparation of these scaffolds was achieved by employing a C-H functionalization strategy. This method allows easy access to these biaryl motifs by precluding the necessity of preparing specific coupling partners, although poor regioselectivity is sometimes observed when more than one reactive C-H is present on the substrate. In an effort to circumvent this liability, we envisioned the use of a carboxylic acid moiety as a blocking group that could be later functionalized or removed. Remarkably, the coupling was found to occur exclusively at the position previously occupied by the acid, even in the presence of a reactive C-H group. This selective transformation was also found to proceed with other heteroaromatic carboxylic acids, allowing for the preparation of a variety of aryl-substituted heteroaromatics that would be difficult to obtain via other methods. Copyright

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2737O – PubChem

Can You Really Do Chemisty Experiments About 3-Methylbenzofuran-2-carboxylic acid

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“Chemical Equation Presented” A full overview of the decarboxylative cross-coupling reaction between heteroaromatic carboxylic acids and aryl halides is described. This transformation employs palladium catalysts with short reaction times providing facile synthesis of aryl-substituted heteroaromatics. The effect of each reaction parameter including solvent, base, and additive employed as well as the full substrate scope of this transformation are reported. Mechanistic evidence is also disclosed that sheds light on possible reaction pathways.

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Benzofuran – Wikipedia,
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Some scientific research about 3-Methylbenzofuran-2-carboxylic acid

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A cobalt-catalyzed decarboxylative cross-coupling reaction of (hetero)aryl carboxylic acids with benzothiazoles or benzoxazoles is reported. This represents a first example of metal-catalyzed decarboxylative C-H heteroarylation of benzo-fused heterocycles. The transformation provides a convenient route, with good yields and functional group tolerance, to various important arylheteroaryl and unsymmetrical biheteroaryl structural motifs.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2757O – PubChem

A new application about 3-Methylbenzofuran-2-carboxylic acid

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Myeloid cell leukemia 1 (Mcl-1), a member of the Bcl-2 family of proteins, is overexpressed and amplified in various cancers and promotes the aberrant survival of tumor cells that otherwise would undergo apoptosis. Here we describe the discovery of potent and selective Mcl-1 inhibitors using fragment-based methods and structure-based design. NMR-based screening of a large fragment library identified two chemically distinct hit series that bind to different sites on Mcl-1. Members of the two fragment classes were merged together to produce lead compounds that bind to Mcl-1 with a dissociation constant of <100 nM with selectivity for Mcl-1 over Bcl-xL and Bcl-2. Structures of merged compounds when complexed to Mcl-1 were obtained by X-ray crystallography and provide detailed information about the molecular recognition of small-molecule ligands binding Mcl-1. The compounds represent starting points for the discovery of clinically useful Mcl-1 inhibitors for the treatment of a wide variety of cancers. I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 24673-56-1, help many people in the next few years.SDS of cas: 24673-56-1

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2738O – PubChem