Category: 24673-56-1

24673-56-1, 3-Methylbenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3-methyl-benzofuran-2-carboxylic acid (0.98 g, 5.6 mmol) and catalytic amount of DMF (5 drops) in THF (25 ml) was added oxalyl chloride (0.53 ml, 6.1 mmol). After stirring the solution for 1 h at room temperature, methanol (20 ml) and TEA (7.0 ml) were added. The reaction mixture was stirred overnight at room temperature, then concentrated and dissolved in ethyl acetate (100 ml) and washed with aqueous sodium bicarbonate solution (100 ml). The organic layer was dried over sodium sulfate and concentrated to provide crude methyl 3-methylbenzofuran-2-carboxylate (1.0 g, 5.3 mmol) as a tan solid, which was used without further purification., 24673-56-1

24673-56-1 3-Methylbenzofuran-2-carboxylic acid 600591, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; AXYS PHARMACEUTICALS, INC.; WO2005/19174; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

24673-56-1, 3-Methylbenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-methylbenzofuran-2-carboxylic acid (35.2 mg, 0.2 mmol), NIS (47.3 mg, 0.21 mmol), palladium acetate(0.9 mg, 0.002 mmol), and a stirrer were placed in the reaction tube. After replacing the inert gas, 1 ml of solvent DMF was added, Sealed reaction tube. The reaction tube was placed in an oil bath reaction reactor at 80 C and stirred for 12 hours. After cooling to room temperature, use 2 mol / L Sodium hydroxide solution to adjust pH = 10. The reaction tube was diluted with 5 ml of water and extracted with ethyl acetate. Combined extract, And dried over anhydrous sodium sulfate. The filtrate was concentrated under reduced pressure and then extracted with ethyl acetate: petroleum ether = 0 to 1: 30 (volume ratio) The eluate was subjected to column chromatography on the crude product to give pure 3-methyl-2-iodobenzofuran (39.2 mg, 76%).

24673-56-1, As the paragraph descriping shows that 24673-56-1 is playing an increasingly important role.

Reference£º
Patent; Xiangtan University; Gong Xing; Cai Changqun; Yang Yun; (24 pag.)CN106748604; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

24673-56-1, 3-Methylbenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Methylbenzofuran-2-carboxylic acid (commercially available) was heated withcopper metal in quinoline to give compound 5. Colorlessoil, 1H-NMR (500 MHz, CDCl3) delta: 2.22 (3H, d, J=1.2 Hz),7.18-7.26 (2H,m), 7.38 (1H, dd, J=1.2, 8.0 Hz), 7.48 (1H, m),7.51 (1H, dd, J=1.2, 8.0 Hz). 13C-NMR (125 MHz, CDCl3)delta: 6.4, 110.6, 115.2, 119.0, 121.9, 123.8, 128.4, 141.4, 155.5.Its spectral data are in accordance with previously reported data.

24673-56-1, The synthetic route of 24673-56-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yamaguchi, Yuki; Akimoto, Ichie; Motegi, Kyoko; Yoshimura, Teruki; Wada, Keiji; Nishizono, Naozumi; Oda, Kazuaki; Chemical and Pharmaceutical Bulletin; vol. 61; 10; (2013); p. 997 – 1001;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24673-56-1,3-Methylbenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Was added to the reaction Schlenk tube equipped with a magnetic stirring bar3-methylbenzofurancarboxylic acid 35.0 mg,Potassium carbonate 55.3 mg,1 mL of dichloromethane and 1 mL of dimethyl sulfoxide.The reaction was carried out by heating at 130 C for 5 hours under air conditions.After the reaction was completed, extraction with ethyl acetate three times, 10 mL each time, the combined organic phases were concentrated.36.6 mg of 2-methylbenzofurancarboxylic acid dichloromethyl ester was obtained.The yield was 71%., 24673-56-1

24673-56-1 3-Methylbenzofuran-2-carboxylic acid 600591, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Nanchang University; Cai Hu; Fu Zhengjiang; Wang Shuiliang; Jiang Yongqing; Huang Zhicong; (16 pag.)CN109369391; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

24673-56-1, 3-Methylbenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4- (2-Aminoethoxy) benzoic acid methyl ester hydrochloride (78.90 g, 0.340 mol) and 3- methylbenzofuran-2-carboxylic acid (60.0 g, 0.340 mol) were suspended in acetonitrile (360 ml) and cooled to 0-5 C. Pyridine (137.6 mL, 1.702 mol) was added quickly. A solution of phosphorous oxychloride (52.2 g, 0.340 mol) in acetonitrile (60 ML) was added drop wise over thirty to forty-five minutes with the temperature kept below 20 C. The reaction mixture was allowed to stir for one hour and warm slowly to ambient temperature. After completion of reaction, the solution was added to a rapidly stirred 0-5 C mixture of chlorobenzene (1000 ML) and IN hydrochloric acid (1000 ml). The reaction mixture was stirred rapidly and allowed to warm to room temperature. The organic layer was washed with water, 3% potassium hydroxide, and again with water. Chlorobenzene (100 ML) was added to the washed organic layer. Solvent (100 ML) was then distilled at atmospheric pressure until the pot temperature reached 132 C. After cooling to ambient temperature, 4- {2- [ (3-METHYLBENZOFURAN-2- carbonyl) amino] ethoxy} benzoic acid methyl ester was stored in solution for use in the next step., 24673-56-1

As the paragraph descriping shows that 24673-56-1 is playing an increasingly important role.

Reference£º
Patent; AXYS PHARMACEUTICALS INC.; WO2004/92115; (2004); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem