With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24673-56-1,3-Methylbenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.
Was added to the reaction Schlenk tube equipped with a magnetic stirring bar3-methylbenzofurancarboxylic acid 35.0 mg,Potassium carbonate 55.3 mg,1 mL of dichloromethane and 1 mL of dimethyl sulfoxide.The reaction was carried out by heating at 130 C for 5 hours under air conditions.After the reaction was completed, extraction with ethyl acetate three times, 10 mL each time, the combined organic phases were concentrated.36.6 mg of 2-methylbenzofurancarboxylic acid dichloromethyl ester was obtained.The yield was 71%., 24673-56-1
24673-56-1 3-Methylbenzofuran-2-carboxylic acid 600591, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; Nanchang University; Cai Hu; Fu Zhengjiang; Wang Shuiliang; Jiang Yongqing; Huang Zhicong; (16 pag.)CN109369391; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem