With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24673-56-1,3-Methylbenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.
To a mixture of aniline (0.690 g, 7.41 mmol) in dichloromethane (25 mL), 3-methylbenzofuran-2-carboxylic acid (1c) (1.00 g, 5.7 mmol) was added with stirring. Then DMAP (0.116 g, 0.57 mmol) was added, followed by DCC (1.220 g, 5.9 mmol). The reaction was left to stir at room temperature for 23 h. The reaction mixture was then filtered and the filtrate washed with water (20 mL * 2), then 5% acetic acid (20 mL * 2) and again with water (20 mL * 2). The crude product was recrystallized from methanol to yield 2c as off-white crystals (0.896 g, 63%), mp 118-120 C. 1H NMR (300 MHz, CDCl3) delta 2.68 (s, 3H), 7.13-7.18 (t, J = 7.4 Hz, 1H), 7.30-7.52 (m, 5H), 7.62-7.65 (d, J = 7.57 Hz, 1H) 7.72-7.73 (d, J = 8.57 Hz, 2H), 8.35 (s, 1H). 13C NMR (300 MHz, CDCl3) delta 9.1, 111.6, 120.0, 121.1, 123.4, 123.9, 124.6, 127.5, 129.2, 129.9, 137.5, 142.4, 153.3, 158.1. MS(ESI)+ calcd for C16H14NO2 [M+H]+: 252.1025, found: 252.1027., 24673-56-1
As the paragraph descriping shows that 24673-56-1 is playing an increasingly important role.
Reference£º
Article; Marriott, Karla-Sue C.; Morrison, Andrew Z.; Moore, Misty; Olubajo, Olarongbe; Stewart, Leonard E.; Bioorganic and Medicinal Chemistry; vol. 20; 23; (2012); p. 6856 – 6861;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem