Tag: 24673-56-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24673-56-1,3-Methylbenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a mixture of aniline (0.690 g, 7.41 mmol) in dichloromethane (25 mL), 3-methylbenzofuran-2-carboxylic acid (1c) (1.00 g, 5.7 mmol) was added with stirring. Then DMAP (0.116 g, 0.57 mmol) was added, followed by DCC (1.220 g, 5.9 mmol). The reaction was left to stir at room temperature for 23 h. The reaction mixture was then filtered and the filtrate washed with water (20 mL * 2), then 5% acetic acid (20 mL * 2) and again with water (20 mL * 2). The crude product was recrystallized from methanol to yield 2c as off-white crystals (0.896 g, 63%), mp 118-120 C. 1H NMR (300 MHz, CDCl3) delta 2.68 (s, 3H), 7.13-7.18 (t, J = 7.4 Hz, 1H), 7.30-7.52 (m, 5H), 7.62-7.65 (d, J = 7.57 Hz, 1H) 7.72-7.73 (d, J = 8.57 Hz, 2H), 8.35 (s, 1H). 13C NMR (300 MHz, CDCl3) delta 9.1, 111.6, 120.0, 121.1, 123.4, 123.9, 124.6, 127.5, 129.2, 129.9, 137.5, 142.4, 153.3, 158.1. MS(ESI)+ calcd for C16H14NO2 [M+H]+: 252.1025, found: 252.1027., 24673-56-1

As the paragraph descriping shows that 24673-56-1 is playing an increasingly important role.

Reference£º
Article; Marriott, Karla-Sue C.; Morrison, Andrew Z.; Moore, Misty; Olubajo, Olarongbe; Stewart, Leonard E.; Bioorganic and Medicinal Chemistry; vol. 20; 23; (2012); p. 6856 – 6861;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24673-56-1,3-Methylbenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 185 5-Acetyl-3-methylbenzofuran-2-carboxylic acid Following the procedure of Example 155 but substituting 3-methylbenzofuran-2-carboxylic acid for ethyl 4-hydroxy-3-methylbenzofuran-2-carboxylate, the title compound was obtained. Analysis calc’d: C, 64.71; H, 3.95. Found: C, 65.06; H, 4.14., 24673-56-1

24673-56-1 3-Methylbenzofuran-2-carboxylic acid 600591, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Merck Frosst Canada, Inc.; US4663347; (1987); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

24673-56-1, 3-Methylbenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,24673-56-1

Step 1: 3-Phenethyl-benzofuran-2-carboxylic acid. 3-Methyl-benzofuran-2-carboxylic acid (9.99 g, 56.7 mmol) in 150 mL of anhydrous THF was added under nitrogen dropwise to a solution of lithium diisopropylamide (60 mL of a 2.0 M solution in heptane/THF/ethylbenzene; 120 mmol) in 350 mL of anhydrous THF at -10 C. After the addition was complete the reaction was stirred at -10 C. for approximately 10 minutes. Benzyl bromide (13.5 mL, 113 mmol) was then added dropwise to the reaction. After the addition the reaction was allowed to warm to room temperature and then stirred at room temperature for 2 h. The reaction was acidified by the addition of 1 N HCl and then concentrated under reduced pressure to remove the THF. The residue was partitioned between 1 N HCl and methylene chloride. The aqueous layer was separated and extracted two times with methylene chloride. The combined extracts were dried (MgSO4) and the solvent removed under reduced pressure. The residue was recrystallized from ethyl acetate to give 3-phenethyl-benzofuran-2-carboxylic acid (1.62 g, 11 %) as a white solid, mp 169-172 C. Elemental Analysis for C17H14O3 Calc’d: C, 76.68; H, 5.30; N, 0.00 Found: C, 76.18; H, 5.27; N, 0.02

The synthetic route of 24673-56-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wyeth; US2003/45560; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem