24673-56-1, 3-Methylbenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
4- (2-Aminoethoxy) benzoic acid methyl ester hydrochloride (78.90 g, 0.340 mol) and 3- methylbenzofuran-2-carboxylic acid (60.0 g, 0.340 mol) were suspended in acetonitrile (360 ml) and cooled to 0-5 C. Pyridine (137.6 mL, 1.702 mol) was added quickly. A solution of phosphorous oxychloride (52.2 g, 0.340 mol) in acetonitrile (60 ML) was added drop wise over thirty to forty-five minutes with the temperature kept below 20 C. The reaction mixture was allowed to stir for one hour and warm slowly to ambient temperature. After completion of reaction, the solution was added to a rapidly stirred 0-5 C mixture of chlorobenzene (1000 ML) and IN hydrochloric acid (1000 ml). The reaction mixture was stirred rapidly and allowed to warm to room temperature. The organic layer was washed with water, 3% potassium hydroxide, and again with water. Chlorobenzene (100 ML) was added to the washed organic layer. Solvent (100 ML) was then distilled at atmospheric pressure until the pot temperature reached 132 C. After cooling to ambient temperature, 4- {2- [ (3-METHYLBENZOFURAN-2- carbonyl) amino] ethoxy} benzoic acid methyl ester was stored in solution for use in the next step., 24673-56-1
As the paragraph descriping shows that 24673-56-1 is playing an increasingly important role.
Reference£º
Patent; AXYS PHARMACEUTICALS INC.; WO2004/92115; (2004); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem