With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37418-88-5,4-Hydroxyisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.
A 50-mL round bottom flask was charged with phthalic anhydride Comppund 1a (1.1 g, 6.70 mmol) and dry toluene (30 mL). Compound 23h (2.2 g, 6.79 mmol) and triethylamine (1.2 mL, 8.61 mmol) were added to the mixture. A Dean-Stark trap was attached to the flask and the mixture was refluxed for 24 h. The mixture was cooled to room temperature, diluted with dichloromethane (200 mL), and washed with 1.0 N HCI (100 mL). The organic layer was dried using MgSC>4, filtered through Celite.(R)., and concentrated in vacuo, to give 3.1 g (98percent) of Compound 23i as a yellow solid. 1H NMR (300 MHz, CDCI3) delta 7.66-7.70 (m, 1 H), 7.52-7.57 (m, 1 H), 7.06-7.16 (m, 1 H), 6.79-6.88 (m, 3 H), 5.16-5.21 (m, 1 H),3.88 (s, 3 H), 3.85 (s, 3 H), 3.06-3.19 (m, 1 H), 2.49-2.56 (m, 1 H), 2.26-2.33 (m, 1 H), 1.46-1.56 (m, 2 H), and 1.42 (s, 9 H).
37418-88-5, As the paragraph descriping shows that 37418-88-5 is playing an increasingly important role.
Reference£º
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2007/81995; (2007); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem