Category: 128851-73-0

Design, synthesis, and LFA-1/ICAM-1 antagonist activity evaluation of Lifitegrast analogues was written by Du, Guoxin;Du, Weiwei;An, Yuanlong;Wang, Minnan;Hao, Feifei;Tong, Xiaochu;Gong, Qi;He, Xiangdong;Jiang, Hualiang;He, Wei;Zheng, Mingyue;Zhang, Donglei. And the article was included in Medicinal Chemistry Research in 2022.Reference of 128851-73-0 This article mentions the following:

In this study, designed and synthesized some new structure compounds that were analogs to Lifitegrast, and their biol. activities were evaluated by in vitro cell-based assay and also by in vivo mouse dry eye model. The results demonstrated that one of these analogs of Lifitegrast (compound I = Ar¹-X = (benzofuran-6-ylmethyl)carbamoyl, Ar² = (methylsulfonyl)phenyl ) showed good LFA-1/ICAM-1 antagonist activity in in vitro assay; meanwhile, it also significantly reduced ocular surface epithelial cells damage, increased goblet cell d. in dry eye mouse and highly improved the symptoms of dry eye mouse. In the experiment, the researchers used many compounds, for example, 6-Bromobenzofuran (cas: 128851-73-0Reference of 128851-73-0).

6-Bromobenzofuran (cas: 128851-73-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Reference of 128851-73-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Enhancing the Thermal Stability of Solution-Processed Small-Molecule Semiconductor Thin Films Using a Flexible Linker Approach was written by Gasperini, Andrea;Jeanbourquin, Xavier A.;Rahmanudin, Aiman;Yu, Xiaoyun;Sivula, Kevin. And the article was included in Advanced Materials (Weinheim, Germany) in 2015.Recommanded Product: 128851-73-0 This article mentions the following:

The authors demonstrate a flexible-linker strategy for mol. organic semiconductors using a common small-mol. donor, 3,6-bis(5-(benzofuran-2-yl)thiophen-2-yl)-2,5-bis(2ethylhexyl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione, coded as DPP(TBFu)₂. When the flexibly linked material is employed as an additive in thin films, a unique level of control is observed over the morphol. and the thermal stability of pure donor films in transistor devices and in blends with PC₆₁BM for BHJ photovoltaics. The synthesis of the flexibly linked DPP(TBFu)₂ derivative [coded FL-DPP(TBFu)₂] is shown schematically. The Stille-coupling polycondensation between the brominated diketopyrrolopyrrole core and the stannylated benzofuran dimer followed by standard purification and finally preparatory size exclusion chromatog. afforded the pure polymer with a number average mol. weight, M_n of 10 kDa and a PDI of 1.4 ( n = 11 – 15) in the hundred-milligram scale. In the experiment, the researchers used many compounds, for example, 6-Bromobenzofuran (cas: 128851-73-0Recommanded Product: 128851-73-0).

6-Bromobenzofuran (cas: 128851-73-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Recommanded Product: 128851-73-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Biocatalytic strategy for highly diastereo- and enantioselective synthesis of 2,3-dihydrobenzofuran-based tricyclic scaffolds was written by Vargas, David A.;Khade, Rahul L.;Zhang, Yong;Fasan, Rudi. And the article was included in Angewandte Chemie, International Edition in 2019.Reference of 128851-73-0 This article mentions the following:

2,3-Dihydrobenzofurans are key pharmacophores in many natural and synthetic bioactive mols. A biocatalytic strategy is reported here for the highly diastereo- and enantioselective construction of stereochem. rich 2,3-dihydrobenzofurans in high enantiopurity (>99.9% de and ee), high yields, and on a preparative scale via benzofuran cyclopropanation with engineered myoglobins. Computational and structure-reactivity studies provide insights into the mechanism of this reaction, enabling the elaboration of a stereochem. model that can rationalize the high stereoselectivity of the biocatalyst. This information was leveraged to implement a highly stereoselective route to a drug mol. and a tricyclic scaffold featuring five stereogenic centers via a single-enzyme transformation. This work expands the biocatalytic toolbox for asym. C-C bond transformations and should prove useful for further development of metalloprotein catalysts for abiotic carbene transfer reactions. In the experiment, the researchers used many compounds, for example, 6-Bromobenzofuran (cas: 128851-73-0Reference of 128851-73-0).

6-Bromobenzofuran (cas: 128851-73-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Reference of 128851-73-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Visible-Light-Induced α-Amino C-H Bond Arylation Enabled by Electron Donor-Acceptor Complexes was written by Xu, Chang;Shen, Fang-Qi;Feng, Gaofeng;Jin, Jian. And the article was included in Organic Letters in 2021.Product Details of 128851-73-0 This article mentions the following:

Enabled by electron donor-acceptor complexes, a novel visible-light-induced α-amino C-H bond arylation protocol, without a photoredox catalyst, was disclosed. The protocol does not require any transition metal, oxidant, or exclusion of oxygen or moisture. A direct irradiation of the mixture of tertiary amines and benzonitriles with visible light in N,N-diethylethanamide in the presence of Cs₂CO₃ afforded α-arylated amines in good to excellent yields. In the experiment, the researchers used many compounds, for example, 6-Bromobenzofuran (cas: 128851-73-0Product Details of 128851-73-0).

6-Bromobenzofuran (cas: 128851-73-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Product Details of 128851-73-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Visible-Light-Induced α-Amino C-H Bond Arylation Enabled by Electron Donor-Acceptor Complexes was written by Xu, Chang;Shen, Fang-Qi;Feng, Gaofeng;Jin, Jian. And the article was included in Organic Letters in 2021.Product Details of 128851-73-0 This article mentions the following:

Enabled by electron donor-acceptor complexes, a novel visible-light-induced α-amino C-H bond arylation protocol, without a photoredox catalyst, was disclosed. The protocol does not require any transition metal, oxidant, or exclusion of oxygen or moisture. A direct irradiation of the mixture of tertiary amines and benzonitriles with visible light in N,N-diethylethanamide in the presence of Cs₂CO₃ afforded α-arylated amines in good to excellent yields. In the experiment, the researchers used many compounds, for example, 6-Bromobenzofuran (cas: 128851-73-0Product Details of 128851-73-0).

6-Bromobenzofuran (cas: 128851-73-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Product Details of 128851-73-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem