With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13196-11-7,Benzofuran-6-ol,as a common compound, the synthetic route is as follows.
General procedure: To a mixture of 6 (1 mmol) and potassium carbonate (3 mmol) in anhydrous DMF (5 ml) was added corresponding benzo cyclic phenol (1.1 mmol). After the resulting mixture was heated at 90-110 C for 3-10 h, the reaction was cooled to room temperature and poured into water (15 ml). The mixture was extracted with ethyl acetate for three times, and the organic layers were combined, washed with saturated brine (20 ml x 2), dried over anhydrous magnesium sulfate and evaporated under reduced pressure. The residue was purified by flash column chromatography to yield the desired compound.
13196-11-7, 13196-11-7 Benzofuran-6-ol 128844, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Article; Zou, Qingan; Duan, Hongliang; Ning, Mengmeng; Liu, Jia; Feng, Ying; Zhang, Liming; Zhu, Junjie; Leng, Ying; Shen, Jianhua; European Journal of Medicinal Chemistry; vol. 82; (2014); p. 1 – 15;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem